Does Sinemet does a good job in improving fatigue compared to other Parkinson's medications?
Case history:
My mom, 58 years old was diagnosed with Parkinson's two years back. Her major symptom is Fatigue and drug induced dystonia. Then the neurologist prescribed the following set of tablets:
Sinemet CR (125mg)- 0.5-0.25-0.25-0.5
Ropinirole CR (2mg)- 1-0-0-1
Amantadine (50mg)- 0-0-0-1
Safinamide (100mg) - 1-0-0-0
With these above set of medications, my mom was doing better - improved fatigue, ability to travel. Although drug induced dystonia existed during Sinemet - usually quite deliberating pain during the evening dose.
Unfortunately the neuro passed away two weeks back and we had to consult another neurologist. He did a complete change over of medications as follows:
Ropinirole (0.5 mg) 1-1-0-1
Amantadine(100mg)1-1-0-1
Safinamide (50mg) - 1-0-0-1
Sinemet (110mg)- 0.25-0-0.25-0 (only if needed)
The problem now is:
No drug induced dystonia
Deliberating fatigue
Lower back pain
Leg feeling uneasy
My questions are:
Although Sinemet is reduced significantlyand also no more Constant Release tablets in the new neuro's medication list, still the other medicine doses have been made high. Won't those help to maintain same levels of Levodopa concentrations and provide relief?