Nicotinamide Riboside supplement

[Astronomer90]

I heard a quite bit about Nicotinamide Riboside recently that it helps with PD. When I look at Amazon, this supplement is around $150 from Tru Niagen. But it is only $30+ from other providers. I am wondering what is the difference? Why such a huge price difference? Please share which brand you are using?

[jimcaster]

I'm buying TruNiagen because they appear to be at the forefront and their formula is patented, but it's definitely not cheap.

[jimcaster]

Just FYI: Here's a recent article with encouraging news regarding nicotinamide riboside.

neurosciencenews.com/nicoti...

[Michel0220 in reply to jimcaster]

Thank you very much Jim for sharing this interesting article. I have started taking NR 10 days ago. Based on recent research by L Mischley, this is a supplement that is worth considering.

[Bolt_Upright]

I see TruNiagen has about 3.5 grams of Inulin. That should be really helpful on its own (Boost SCFAs).

[WinnieThePoo in reply to Bolt_Upright]

Did you not also post that a patent dispute should bring down the price. TruNiagen is $450 a month at Jimcaster dosage I think. We have this source in Francehexagonsupplements.co/produ...

[reedboat2]

I recently heard about some research, indicating that NR could be carcinogenic. I’m not sure about the source of that rumor. Anybody have any information on that? Thanks- JG

[reedboat2 in reply to reedboat2]

I’ll reply to my own question. I called Life Extension. They said they’re fielding a lot of questions on the subject. It seems a mouse study was published in November 22. It was a small study, and the results were questionable. LE does not consider it significant to the continued use of NR

[Windermere1]

I have been taking TruNiagen for over a year to stop my RLS. I also have Parkinson’s

[princesspanda in reply to Windermere1]

Did it help your RLS? What dosage do you take? Thank you!

[Windermere1 in reply to princesspanda]

I started a year ago on 300mg daily and slight improvements came within a month so I increased to 2 x 300 mg daily and RLS gone. A year on I’m still taking 600mg and still no RLS, I HAVE READ RECENTLY THAT TESTS ARE ONGOING TO SEE IF IT IMPROVES PD SYMPTOMS. I TAKE HIGH DOSE B1 for PD And IT HAS GIVEN ME MY LIFE BACK

[TL500 in reply to Windermere1]

Did you take high Dose B1 before or after TruNiagen? Which one do you think helping you?

By "given me my life back", you mean all your symptoms are gone and you are back to before PD? Thanks

[Windermere1 in reply to TL500]

I started TruNiagen Jan 1 last year and RLS resolved by March. Started b1 sublingual April 1st and it took at least two months to find sweet spot. Then lots of improvements (see my video on utube Parkinson’s b1 therapy Julie’s story) too many improvements to list here. But I’m not where I was before Parkinson’s but it’s no longer in control of my whole life. I am. Have some great days and still a few bad ones but I’m 78 and will fight on.

[TL500 in reply to Windermere1]

Wow for 78 year old you are doing very well! Thanks for sharing.Did you start Restore Gold after B1?

How do you know which one is helping?

[Windermere1 in reply to TL500]

what is Restore Gold. I don’t take it.

[TL500 in reply to Windermere1]

Sorry, I got mixed up. TruNiagen and b1 how do you know which one is helping what?

[Windermere1 in reply to TL500]

I know for definite that TruNiagen solved my RLS. But not noticed any effect on PD but read recently they are trialing it for PD. B1 is the big deal in easing numerous PD symptoms. Have you read Daphne Bryan’s book Parkinson’s b1 therapy or joined fb group of same name. Hundreds of people finding the same successes.

[TL500 in reply to Windermere1]

I like your video. It's great! I think it will help people with PD who are looking for alternative medicine with hope.

Do you still take TruNiagen?

Yes I have read the book and also joined FB, I am not good at FB so only can see the recent comments. I don't know how to go to see all comments from everyone to date.

How are you taking B1 sublingual? Is it 100mg per day?

[Windermere1 in reply to TL500]

yes I still take 600mg of TruNiagen daily for my RLS. I actually take 50mg of sublingual B1 every other day this dose is my sweet sport and produces all my PD improvements. Not as effective for my right hand tremor as it is for other people but I can live with that for all the other benefits.

[TL500 in reply to Windermere1]

So half a tablet every second day?

Doesn't b1 help you with RLS?

Does RLS make your legs uncomfortable and tired at bedtime?

[Windermere1 in reply to TL500]

yes 1/2 tablet every other day. But we are all different. This is just my need after a year of taking it. I don’t know if B1 helps RLS because I fixed my RLS with TruNiagen before I started B1 therapy. If you trial more than one protocol at the same time you will never know which one worked. When I had RLS my legs never stopped kicking at night in bed. It drove me crazy and that’s why it was my first fix because it was worse than my PD symptoms.

Now thankfully both under control. Thanks to both B vitamins.

[TL500 in reply to Windermere1]

I'm happy for you. Do you take any other supplements?

[Windermere1 in reply to TL500]

yes I take magnesium Citrate to control my PD constipation. Magnesium LThreonate High dose b12 and high dose D3 with K2 and a b complex. I’ve gone from never taking anything even for a headache to taking lots to support and help my PD symptoms in an effort to delay progression. So far so good.

[TL500 in reply to Windermere1]

Same here, from never taking anything even for headache to taking lots of supplements some in high doses hoping to delay PD or recover from it like a few people have.How much of each do you take

[rescuema in reply to Windermere1]

"my legs never stopped kicking at night in bed."

It sounds like hypic jerk or myoclonic jerk than RLS.

[Windermere1 in reply to rescuema]

definitely was RLS but now gone

[rescuema in reply to Windermere1]

Myocclonus or PLMS is just as evil as RLS for sleep deprivation all night, though RLS can often accompany PLMS while they're distinct conditions.

I'm curious - was your main symptom involuntary jerks/kicking or an urge to move your legs, or both? I'm glad that NR (Tru Niagen) worked for your relief, while it unfortunately doesn't work for everyone for RLS. Be sure to support your methylation with TMG if any adverse effects are observed with the continued use of NR.

RLS definition below-

mayoclinic.org/diseases-con...

[Sydney75 in reply to rescuema]

Whats is PLMS? My HWP RLS is not really helped when walking around. If he forgets 2mg Neupro patch its happens that evening. I would like to get off Neupro bc of the augmentation I have read about. Looking for alternatives to patch, read its is hell to get off. What is TMG? I think he was myclonic jerks. Thanks in advance.

[rescuema in reply to Sydney75]

As to the uncontrollable urge to move the legs associated with RLS, PLMS is periodic limb movements in sleep or involuntary jerking/kicking during sleep, also known as myoclonus. I've recently commented on it on Bolt's thread below.

healthunlocked.com/cure-par...

Also, I commented on why using glycine (as with high dose B3 or NR) may work for RLS in certain people in relation to methylation and excess glutamate below. They dump methyl donors.

healthunlocked.com/cure-par...

TMG is Betaine or trimethylglycine for methyl support. More on this is below.

chrismasterjohnphd.substack...

[Astronomer90 in reply to Windermere1]

Does it help with tremors?

[Windermere1 in reply to Astronomer90]

not really for me but other people say yes

[Sydney75 in reply to Windermere1]

Thanks for more info, my HWP has RLS too I am going to try TruNiagin. Do you have any strange side effects?

[Windermere1 in reply to Sydney75]

no side effects

[lamboman]

Is NR supplement really effective? what improvement do you find with PD?

[WinnieThePoo]

Also, any idea why the No Park trial opted for 1000mg per day, when Chromadex list the daily dose as 300mg on their bottles?

[Router_]

They changed the dosage in the follow up due to change in dosage per capsule, I believe they opted for 1200 MG per day now

[WinnieThePoo in reply to Router_]

I understand why 1200 is 4x300. I don't understand why chromadex print on their bottles that the daily amount is one capsule and then run a trial where its 4 capsules. Where did that number come from? Why 4 and not 2 or 8?Have they already carried out a dose escalation trial?

[Lizzy9]

Hello ~ I started my HwP on TruNiagen a year ago. I don’t know what it’s doing for his PD, but about 3 weeks after starting it there was a noticeable improvement in his cognition. Most of the past year I’ve had him on 900 mg (3 pills a day). Every once in a while I’ll change him to 600 mg/ day. For a short time.

You can set up auto ship with the company and it’s cheaper that way ~ but still expensive. Since I have witnessed the improvements I think it’s worth the cost.

I hope this helps!

Have a fabulous day!

[Mymomsadvocate]

check this study out! Plus, I’m learning that nicotine itself is not addictive but when combined with another ingredient are the reasons why people get addicted to cigarettes. When you have nicotine in a patch, it is taken up into the body safely!!!!

And who knew we had nicotine receptors in our bodies??! I have never even heard of that! So this completely makes sense! Why has this been hidden for so long?? The research is old.

fight-parkinsons.org/wp-con...

[Router_ in reply to Mymomsadvocate]

Because the theory of nictotine being beneficial has been debunked in a placebo controlled trial looking at patches:

michaeljfox.org/news/nicoti...

[JayPwP]

Nicotinamide Riboside or NMN?

I am in India and NR seems to be very expensive. NMN seems to be available and within budget for me.

[JayPwP]

What are your thoughts here?

healthunlocked.com/rlsuk/po...

[JayPwP]

Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy

sciencedirect.com/science/a...

[JayPwP]

youtu.be/bRWT7hVgwuM(Not working as expected?)

[Fireside15]

As for the original question in the post, I am searching for a good source of nicotinamide riboside that doesn't break the bank. Any more feedback from anyone?