Green tea, turmeric, and black pepper to ... - Cure Parkinson's

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Green tea, turmeric, and black pepper to increase dopamine

n8urluvr profile image

I've recently been reading that green tea, turmeric, and black pepper can serve as inhibitors of MAO-- enzymes that break down neurotransmitters, including dopamine, in the brain. I just started supplementing with these natural products. Does anyone have experience with this?

35 Replies

Licorice root extract as MAO-B inhibitor:

healthunlocked.com/cure-par...

I drink a LOT of green tea and take turmeric and sometimes black pepper (on & off) and believe each is good for me, but I don't expect to feel a direct benefit from such as I don't expect to feel a clear & direct benefit from any nutritional stuff ingested. In other words, just because we don't feel a benefit, doesn't mean it's not beneficial.

chartist profile image
chartist in reply to MBAnderson

Marc,

I was talking to someone about PD the other day and I said, If you stopped disease progression today, would you even realize it in a year or two years or five years? Possibly not.

It's too early to know, but I would not be surprised if FMT is found to stop disease progression. It seems to at least partially reverse motor and non motor symptoms fairly quickly.

Art

kevowpd profile image
kevowpd in reply to chartist

5 years? You ought to know after 5 years. Its slow. It usually isnt that slow.

Have there been any placebo controlled trials for FMT?

chartist profile image
chartist in reply to kevowpd

If all that happens is that nothing changes from today for better or worse over the next 5 years, how would anyone know considering some PwP have gone 5 years without apparent disease progression?

FMT is only starting in testing with PwP. Two completed studies so far.

Art

kevowpd profile image
kevowpd in reply to chartist

Is that a "no"? Seems a bit early to be calling it the great white hope to me.

I would say no apparent progression in 5 years is exceedingly rare if we are talking about assessment by a neuro or MDS, accompanied by appropriate records that allow a comparison. In any event, i said "usually". Most PWP would start to twig if their condition had frozen for 5y.

chartist profile image
chartist in reply to kevowpd

These are the two PwP studies :

healthunlocked.com/cure-par...

The point is that some PwP have gone 5 years with no apparent progression so how would you know if something you are doing has stopped progression of the disease? No it is not common at all, but that is not the point I was making.

Art

kevowpd profile image
kevowpd in reply to chartist

How well documented is this 5 year with no progression thing?

chartist profile image
chartist in reply to kevowpd

I think people on this forum have mentioned it. Dr. Mischley has a chart that shows the variations in progression over time in patients. That has been posted on this forum several times. That is not the point I am making, the point is how do you know if you are doing something that has halted progression of the disease if nothing changes from today into the future for better or for worse or if you happen to just be a very slow progressor?

Art

kevowpd profile image
kevowpd in reply to chartist

If you are referring to the chart in the 'materials and methods' section at this page:

hindawi.com/journals/omcl/2...

Then it doesnt say people have gone 5 years without progression. It says different people self-report different pro-pd scores at any given disease-duration level. It is an awfully long way from suggesting that anyone's progression has frozen for 5 years.

Yes, some people report slower progression than others, and some people are assessed by doctors as progressing more slowly than others.

Changes in PD are subtle, usually, but they are there. Most PWP dont need a timeline of 5 years to recall and observe changes in their condition. Which means most PWP would recognise no progression over 5 years. I agree that if is this were to happen, isolating the cause would be very difficult unless you'd been on some new wonderdrug for 5 years.

Frankly, in the current treatment environment, the likely explanation for an objectively assessed and well documented absolute freezing (i.e no deterioration whatsoever) of ones condition for 5 years would suggest it isnt PD after all.

chartist profile image
chartist in reply to kevowpd

Dr. Mischley's chart is the one I was referring to. You continue to avoid the point I was making. If a person stops PD progression today, how would they know , as they would remain the same as time passed except for natural deterioration with increased age.

Art

kevowpd profile image
kevowpd in reply to chartist

Well after 5 years, they'd notice that their PD had not worsened since 2021.

chartist profile image
chartist in reply to kevowpd

Have they halted progression or are they just a very slow progressor? How can you tell which one it is?

Art

kevowpd profile image
kevowpd in reply to chartist

Well if you've been progressing at 5 MDSUDPRS points (which is probably close to average) per year for 5 years, then you go 5 years without progressing any points at all, you are going to notice. If you went at 2 points a year for 5 years, then another 5 years at 0 points a year, you are going to notice.

Now, this change may be due to some intervention. I'd be shocked if it was explained by the fact that you are 'just a very slow progressor', since Parkinsons is a progressive condition, and most well documented evidence is that PWP continue to get worse (as I said above, at something like 5 MDSUDPRS points per year), despite what people may self-report on the internet.

I agree with you re 1 or 2 years, btw. But 5 years is different, in my mind.

I'm not endorsing. I'm just sharing. The default order is enemas, but I would make sure I got the poop pills. Microbioma, email admin@microbioma.org

microbioma.org/en/order-fmt/

B_U,

Wow, I was not expecting that!!!

Art

Their page has added a wow factor in the last couple of months.

rebtar profile image
rebtar in reply to Bolt_Upright

How to know how legit these folks are? Quality of product?

Bolt_Upright profile image
Bolt_Upright in reply to rebtar

You could join some FMT groups on FB and get anecdotal testimonials.

rebtar profile image
rebtar in reply to Bolt_Upright

Any you can suggest?

Bolt_Upright profile image
Bolt_Upright in reply to rebtar

facebook.com/groups/FecalTr...

facebook.com/groups/1676427...

facebook.com/groups/2140010...

marcet profile image
marcet in reply to chartist

Sorry but what is FMT ?

Bolt_Upright profile image
Bolt_Upright in reply to marcet

Fecal Microbiota Transplant. Poop transplant.

marcet profile image
marcet in reply to Bolt_Upright

Thanks, very interesting, any experience someone with Microbiota ?

chartist profile image
chartist in reply to marcet

It is not available for PD yet, but is used for other health issues.

designershitdocumentary.com...

Based on these uses and those two FMT/PwP studies as well as the increased attention it is getting, it may be available for PwP in the not too distant future, but it would likely be very helpful If the Michael J Fox Foundation would fund a study given the very good results achieved in the 2020 and 2021 FMT/PwP studies.

Art

LauraYu profile image
LauraYu in reply to chartist

Hi Art, does it even matter whether it is available for PD? FMT is just to transfer gut bacteria from a healthy individual to PD. Now I see that they already have the stool on sale 😂 why can’t we just buy and Do it ourselves? Laura

LauraYu profile image
LauraYu in reply to chartist

Please ignore my question. Did some research, the gut- brain connection is complex and if not handled properly, the FMT can even be dangerous. On several FB groups, the results of FMT are mixed, some see benefits right away, and others even get worse/ neuropathy……. PD treatment may need specific targeted bacteria, instead of general transplant. It could be a long way to go!

chartist profile image
chartist in reply to LauraYu

Laura,

If on the groups where you go, these people are self administering, they are likely using FMT with an enema as the means of delivery which I don't think is going to be as effective as colonoscopy delivery. The enema delivery does not go nearly as far into the colon as colonoscopy delivery, which is what they used in the studies and was very effective.

Art

LauraYu profile image
LauraYu in reply to chartist

Those people on FB groups, some used self administering enema, and some were done in clinic/ hospitals, also the donors made a difference too…….. Yes, serious disease like PD definitely need professional help, hopefully the next clinical trial that you sent the other day yields positive results🙏🙏🙏

chartist profile image
chartist in reply to marcet

FMT= Fecal Microbiota Transplantation :

healthunlocked.com/cure-par...

Art

Grumpy77 profile image
Grumpy77 in reply to chartist

FMT.... Google says Fecal Microbiota TransplantIs this what you are talking about?

chartist profile image
chartist in reply to Grumpy77

Grumpy,

Yes. Here is info on it on how it has worked in PwP from two studies, one from 2020 and one from 2021.

healthunlocked.com/cure-par...

Art

What books/articles did you find this info? I am interested!