“While it is certainly notable that many neurodegenerative diseases can cause malfunction in dopamine neurons (Parkinson's, MS, Infections, FMNP, CFS) - that doesn't mean that dopamine issues can not occur without their involvement...and organic and / or idiopathic (of unknown cause) dopamine deficiency is not the only form of imbalance nor does it always affect receptor expression and / or internalization.There's also drug-induced downregulation - a problem encountered often in scientific study and sometimes in mental patients taking specific Psychiatric medications. Some antibiotics may influence receptor expression as well.ADHD sufferer's who take Ritalin should be made aware that their medication may decrease in effectiveness over time - in part due to downregulation of dopamine receptors as well as increase in dopamine transporter activity...Parkinson's patients on dopamine agonist drugs may experience a lessening in effects/benefits after the period of 3-6 months - an effect that can also be prevented and / or reversed by the below methods.”
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A review article in the International Journal of Psychiatry in Clinical Practice evaluates how effective Silexan might be for patients with different anxiety disorders. Silexan is a lavender-oil preparation available in 80-milligram (mg) gelatine capsules.The team found that Silexan had an anxiolytic, or anxiety-reducing, effect on patients with generalized or subsyndromal anxiety within 2 weeks.Researchers have also foundTrusted Source that lavender scent may help anxious dental patients.
Inositol
Inositol is a type of sugar that the body uses to make cell membranes. It also helps regulate insulin levels, which means that it can have benefits for people with conditions such as metabolic syndrome and polycystic ovary syndrome (PCOS).There is some evidenceTrusted Source that inositol may also help with some mental health conditions, as it may act on neurotransmitters in the brain and nervous system.
Forskolin is used in Ayurvedic medicine for various conditions, but clinical studies that demonstrate its safety and effectiveness are lacking.Forskolin is a root extract of the Indian plant Coleus forskohlii. It has been used for centuries in Ayurvedic medicine to treat various diseases such as underactive thyroid, heart disease, and respiratory disorders. Although anti-inflammatory and blood-pressure lowering effects have been shown in the laboratory setting, very few clinical trials have been conducted. In addition, only a few studies actually use forskolin as an oral supplement. More studies are needed to determine safety and effectiveness for various conditions in humans.
“A lot of these commonly prescribed spasticity drugs work on the GABA receptors in your brain. Benzo’s, Baclofen, Gabapentin, Lyrica. A sledgehammer to crack a nut, maybe. Powerful drugs at any rate.Piracetam is a cyclic derivative of GABA, structurally it looks very similar. Then again, I don’t know what that means.”
“I’d been dragging my leg more than usual, tired, tired achey legs, hard to stand for any length of time. I thought I was headed downhill, but I’ve been here before, where I think it’s over for me. Eventually I snap out of the doom and gloom and apply some logic.Like, fantastic spasms in my left leg (usually in my right).If my left leg spasms, I am constipated.If my spasticity is worse than usual, I am probably constipated.Full bladder = spasticity.So, plenty of bran, more veg, regular toilet habits, lower spasticity.Then, I started taking 2 grams of Piracetam, 4 times per day.Outstanding. No crutches, no hanging onto walls, can’t keep it up for more than five minutes, but for me it was like night and day.”
What’s the difference between muscle spasticity and rigidity?Muscle rigidity and muscle spasticity are both hypertonic states (a state of abnormally high muscle tone), but they’re different.Rigidity is most commonly associated with basal ganglia injuries, and it’s often seen with Parkinson’s disease. The basal ganglia is a group of structures linked to the thalamus in the base of your brain that are involved with coordination of movement.Rigidity, unlike spasticity, affects all muscles surrounding a particular joint equally. In addition, with spasticity, more rapid movement triggers a stronger involuntary contraction or “catch” of the affected muscles. With rigidity, the increased muscle tone remains constant throughout the range of movement of the affected joint
I don’t really know , I was just going down some rabbit holes. So my thought was those drugs were to reduce the stiffness of spasticity and I was wondering how similar that stiffness was to Parkinson’s rigidity and that last article explains how they differ. So I was wondering if they work on Parkinson’s rigidity too.
I am pretty convinced hubby’s rigidity and his previous anxiety is related to the gaba pathway so I’m wondering if these drugs would reduce the shoulder stiffness which I think might help his hands.
The link I put up is for a different condition, AMN not Parkinson’s but the drugs seem similar
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Forskolin
Parkinson's and RLS at the same time.
NAC symptomatic or disease modifying? 
Parkinson's disease begins in the gastrointestinal tract, large study indicates ScienceDaily :Identified thousands of years ago in Ayurveda
Parkinson's, Dizziness, Tinnitus and Hearing Loss
