The Correct Curcumin for Used in "The Effect of Curcumin on Idiopathic Parkinson Disease: A Clinical and Skin Biopsy Study"

[Bolt_Upright]

So I posted about this remarkable preliminary study that seems to show 1 gram of curcumin twice a day for a year actually improves motor and non-motor symptoms AND reduces the A-Syn detected in the skin. That seems pretty amazing (but it was a small study): The Effect of Curcumin on Idiopathic Parkinson Disease: A Clinical and Skin Biopsy Study healthunlocked.com/cure-par...

According to the original paper the version of curcumin that crosses the BBB is the Meriva which is made with phospholipids.

According to this paper, Most curcumin can't cross the BBB: Neuroprotection by curcumin: A review on brain delivery strategies sci-hub.ru/10.1016/j.ijphar...

From what I can find, you need the Meriva version to get the curcumin to the brain.

I found 2 Meriva products:

Thorne Curcumin Phytosome 1000 mg (Meriva) $51 for 120 500 mg capsules amazon.com/Thorne-Research-...

Now for some good news! I found some cheap Doctor's Best Curcumin Phytosome with Meriva: $35 for 180 500 mg capsules. Take four a day, that is 2 grams a day, 45 day supply for $35. $24 a month! amazon.com/dp/B008YDH4HM?ps...

[Little_apple]

Bravo Bolt! That is great!

[Little_apple]

I’m a little wary of the silicon dioxide added

I assumed it was just in the cheaper one. Nope

It’s in both

[Gcf51 in reply to Little_apple]

What I am reading indicates silicon dioxide is only harmful if you breath in the dust.

[MBAnderson]

Tanks Dave.

[Annieartist]

thanks Bolt-I thought Id had my interest activated by something!

[Sydney75]

Thank you, I assume this product would be different than the "liposomal" version.

[Bolt_Upright in reply to Sydney75]

I think it is different. The key is that it say meriva.

[gregorio]

i thought the version that crossed the BBB was with black pepper

[billybobAK in reply to gregorio]

Does anyoone know about the efficacy of Pro Health's Otimized Curcumin product?

[billybobAK in reply to billybobAK]

AKA Longvida

[Bolt_Upright in reply to billybobAK]

According to this page, SLCP Curcumin CAN cross the BBB: protocolforlife.com/cogumin...

Thanks. I learned something!

[Baron1 in reply to billybobAK]

Pro Health use Longvida product, which has been in clinical trials, that did cross the blood brain barrier. My mother has been taking this supplement since 2015; which is a long time and although I cannot directly attribute any benefits to the Pro Health Curcumin, it has the proven Curcumin ingredient. Best wishes.

[Bolt_Upright in reply to Baron1]

I just noticed that Meriva is made in Italy and all the researchers in this study are Italian. This may be why they chose Meriva! There may be other types of Curcumin that cross the BBB just as well. This is a link to the original paper: academic.oup.com/jnen/artic...

[billybobAK in reply to Baron1]

thanks!

[billybobAK in reply to Baron1]

thanks!

[Bolt_Upright in reply to gregorio]

Please read this paper. It explains it: sci-hub.ru/10.1016/j.ijphar...

[billybobAK in reply to Bolt_Upright]

thanks again. its an interesting article (the parts I could understand)

[coffeewithcream]

globalhealing.com/collectio... Would love your thoughts on this product.

[Bolt_Upright in reply to coffeewithcream]

Thanks for sharing. I looked at it. It is a proprietary blend so I don't think there is any research to indicate it would help with PD. Not sure it would reach the brain either. Also not sure how much curcumin is in the 1 ML dose.

I have a high school degree so I am not an expert on these things. I like to stick to things I can use that have been used in studies.

[CaseyInsights in reply to Bolt_Upright]

This high school graduate is spot on 🌺🕴🌺

[Little_apple]

Revisiting this post to make sure I get the right one. Bolt, you are wonderful. You are really helping us with info and motivation. You aren’t just Bolt. I think of you as Bravo Bolt! ☺️

[Bolt_Upright in reply to Little_apple]

I just noticed that Meriva is made in Italy and all the researchers in this study are Italian. This may be why they chose Meriva! There may be other types of Curcumin that cross the BBB just as well. This is a link to the original paper: academic.oup.com/jnen/artic...

That said, I am happy with the Meriva I bought.

[kaypeeoh in reply to Bolt_Upright]

Yes, your porno name would be Bolt Upright.

[Bolt_Upright in reply to Little_apple]

Simon wrote about Curcumin last year. He was not as excited as I was. He also seems to think I am misreading the results: scienceofparkinsons.com/202...

More to come. I am still sold on Meriva.

[Bolt_Upright in reply to Little_apple]

PS: You are too kind.

[Little_apple in reply to Bolt_Upright]

you must have intended that for Kaypeeohs comment. 😳☺️

[Bolt_Upright in reply to Little_apple]

Too funny

[Bolt_Upright]

Simon wrote about Curcumin last year. He was not as excited as I was. He also seems to think I am misreading the results: scienceofparkinsons.com/202...

More to come. I am still sold on Meriva.

[kaypeeoh]

I've got curcumin plus black pepper. I assume the pepper aids absorption into the blood. But does it cross the BBB?

[Bolt_Upright in reply to kaypeeoh]

I spent over an hour trying to figure out whether curcumin with piperine crosses the BBB. If you Google "curcumin blood brain barrier" you get plenty of results saying curcumin is a lipid so it crosses the BBB. But then you find things saying curcumin is not very bio-available (piperine makes it much more bio-available!) and they are working on ways to make it cross the BBB better.

So... I really don't know. They used Meriva in the trial, but that may be because the researchers were Italian and Meriva is Italian made.

Here is a good article. Makes me think Longvida is the best (maybe): Healing with Enhanced-Bioavailable Curcumin emersonecologics.com/blog/p...

This article shows BCM-95 crosses the (mouse) BBB: Neuroprotective Effect of Turmeric Extract in Combination with Its Essential Oil and Enhanced Brain Bioavailability in an Animal Model hindawi.com/journals/bmri/2...

It is confusing. I will probably stick with Mireva but mix in my BCM-95 stock also until I run out.

[Sydney75]

Found a product that has Mervia and PEA going to try that for pain for HWP. It is expensive but I can do one of these pills and on one of the less expensive version of curcumin that cross BBB. PEA + with 500mg Merva and 300 mg of PEA by Enzyme Science. Auto delivery is cheaper; will try it for two months.

[Bolt_Upright in reply to Sydney75]

I'd feel better if that PEA was Ultra-Micronized or at least Micronized.

I use this PEA. Half a Teaspoon is 600 mg. 100 grams for $50 means 166 days dosages for $50. That is about $10 a month. I put this in applesauce: amazon.com/gp/product/B07NJ...

Then Doctor's Best Curcumin Phytosome with Meriva: $35 for 180 500 mg capsules. Take four a day, that is 2 grams a day, 45 day supply for $35. $24 a month!

[Little_apple]

I’m sorry to rudely derail. I can erase and repost in the right spot.

Bc of your interest in low carb Bolt:

keto-mojo.com/article/keto-...

More surprisingly were the changes in the UPDRS scores. The UPDRS is a scale used to assess symptoms of PD. There were significant improvements in Behavior, Mentation, and Mood scores in 12 weeks. Additionally, improvements in scores on the Depression and Anxiety scales were also seen in 12 weeks, even in the midst of COVID isolation. This was surprising.

parkinsonsnewstoday.com/new...

[Bolt_Upright in reply to Little_apple]

Thanks. I am fully Keto except for the Pepsi (only with real sugar) that I drink.