Dimethyl fumarate : increases NRF2 , already in use for MS

[Little_apple]

Is anyone using this for PD? Dimethyl fumarate has been effective in animal models of PD.

sciencedirect.com/science/a...

Metabolite of multiple sclerosis drug could be safe, effective therapy for Parkinson’s disease

medicalpartnership.usg.edu/...

[LAJ12345]

NRF is the same thing Brocolli sprouts activate.

ncbi.nlm.nih.gov/pmc/articl...

[Little_apple in reply to LAJ12345]

and Moringa

[JDRhope]

More specifically, DMF interacts with the thiol groups on the GSH molecule, which leads to a Michael addition reaction and consequent modifications in GSH levels and function. This initial sequestration of GSH by DMF may trigger an adaptive response, inducing a subsequent increase in both GSH production and recycling (Hoffmann et al., 2017). This latter DMF-induced upregulation of GSH levels contributes in turn to the inhibition of NF-κB and, subsequently, of inflammatory cytokines expression, independently from the Nrf2 pathway activation (Gillard et al., 2015). However, these effects are dose-dependent and also vary based on the cell type; low concentrations of DMF in nontumorigenic cells upregulate GSH levels as mentioned,

frontiersin.org/journals/ph...

[JDRhope]

sciencedirect.com/science/a...

[JDRhope]

Dimethyl Fumarate Exerts a Neuroprotective Effect by Enhancing Mitophagy via the NRF2/BNIP3/PINK1 Axis in the MPP+ Iodide-Induced Parkinson’s Disease Mice Model

DMF treatment significantly alleviated the loss of TH positive dopaminergic neurons and enhanced mitophagy by increasing PINK1, Parkin, BNIP3, and LC3 levels in the MPP+ iodide-induced PD mice model. DMF treatment groups showed good locomotor activity and rearing time when compared to the DC group.

Conclusions:

DMF confers neuroprotection by activating the BNIP3/PINK1/Parkin pathway, enhancing the autophagosome formation via LC3, and improving mitophagy in PD models, and could be a potential therapeutic option in PD.

content.iospress.com/articl...