Day 58 TTFD.

[Gcf51]

*** I ended up with High Blood Pressure taking TTFD. I no longer take TTFD. Based on my experience, I would not recommend TTFD. ***

I sent an email:

Dr. Elliot Overton,

I have Parkinson’s. I have been taking TTFD. I took 50mg for 10days and completely eliminated my PD symptoms, but I was getting very little sleep (1*). Since then I have been taking breaks and decreasing my dose of TTFD. But, I have now run into another major problem – My Blood Pressure is high (I spent an evening in the ER with pressure as high as 205/105). I am taking the 2-1/2 tab Carbidpopa 25/Levodopa 100mg same as before starting TTFD.

I am on day 58 of taking TTFD in the morning (2*) and this is the third day of taking 1/4 of 50mg (3*) after a 7day break with no TTFD. As before, restarting my blood pressure is normal in the morning, but starts to climb around 1pm in the evening (I have been bringing it down with a B-Complex, 100mg L-Glutathione and 500mg TMG.

I have an appointment with my Movement Specialist today and will bring this up with her.

I would like to get back to no symptoms of Parkinson’s (currently only a slight tremor). I was very much interested by your video “Managing Side Effects of Thiamine Supplementation: The Paradoxical Reaction” youtu.be/-DxvSUEVT_4(Not working as expected?) and feel your expertise can help me get back to no symptoms. The only question being how can we proceed? Can you help or offer any suggestions?

1*) I also developed Mania, but have it under control by going back on 250mg of Divalproex 24hr ER (I also take 5mg of Lithium Orotate).

2*) I take a fair amount of supplements mainly in hopes of helping my PD.

3*) I am currently splitting a 50mg into 4 empty caps as close as I can, using a scale.

His office replied do you take magnesium. I replied yes. I got a reply:

Hi there,

Please be aware this is not health advice. Most people require 400mg+, a sign of low magnesium can be high blood pressure. Alternatively, the high blood pressure is also a common sign of the paradoxical reaction. My document covers this in some detail.

Kind regards,

Elliot

I guess, I will purchase his document, I am sure since he says 400mg+. I should try taking more than the 400 I am taking. Note: email revised to update for today.

[Bolt_Upright]

Here is Elliot Overton's about me page. Pretty straightforward. eonutrition.co.uk/about-me

[Gcf51]

My MS didn't have a problem with me taking TTFD. I have to get BP under control...

[PDWarrior1900]

what is TTFD?

[Gcf51]

Thiamine Tetrahydrofurfuryl Disulfide (TTFD) a form of B1. At this time I would not recommend.

[Gcf51]

I purchased Elliot Overton’s “Managing Side Effects of Thiamine Supplementation: The Paradoxical Reaction”. His Protocols are quite a bit different than what is expressed in Dap1948 book and other than the protocol doesn’t say anything different than the video. He does mention some things I have never heard of – like NACET (N-Acetyl Cysteine Ethyl Ester, which supposedly cross the BBB where NAC supposedly doesn’t). And, he writes about using Thiamine HCL, TTFD and Sulbutiamine at time same time (my opinion, sounds unreal given my experience).

“Although N-acetylcysteine crosses the blood-brain-barrier, low bioavailability is an obstacle. One promising avenue of research may be to explore derivatives of N-acetylcysteine such as N-acetylcysteine amide, which has been reported in preclinical studies to have higher permeability through cellular and mitochondrial membranes with increased central nervous system bioavailability compared to N-acetylcysteine.” jpreventionalzheimer.com/25....

“Recent studies have demonstrated the blood-brain barrier permeability and therapeutic potentials of NACA in neurological disorders including Parkinson's disease, Alzheimer's disease, Multiple sclerosis, Tardive dyskinesia, and HIV-associated neurological disorders.” pubmed.ncbi.nlm.nih.gov/234...

I don’t see any purchasing info on NACA, but NACET in fairy expensive.

[Boscoejean]

sigmaaldrich.com/US/en/sear...

[Gcf51]

In his paper Elliot says about a test: “Sulfite:Sulfate ratio: If high: Increased need for molybdenum. Consider supplementing with molybdenum. Epsom salts baths daily are also recommended”. I don’t have the test result and I don’t have the molybdenum supplement, but what harm in trying, I soaked in Epsom salt and ate bean soup yesterday (beans are supposedly a good source of molybdenum). This morning Looking Good. Could be Placebo.