I'm one of those guys that does not like to be told how to do things. I don't much pay attention to whether a supplement bottle says to take something with food or on an empty stomach. How much of a difference can it make? Turns out, it can make a LOT of difference.
VPN is well absorbed from small intestine, which increased by food, therefore, fasting bioavailability is 6.7% and non-fasting bioavailability is 60–100%. intechopen.com/chapters/70917
So I take 30 mg of Vinpocetine twice a day. 60 mg total. Sometimes before I eat. Sometimes after. No real correlation to meals. Doh!
Fasting, 60 mg gets me: 4 freaking mg.
Non-fasting gets me: Between 36 and 60 mg.
Time to review all my supplements!
PS: I do know NAC should be taken at night (that is when your brain cleaner is working) and that NAC works better with Taurine.
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Bolt_Upright
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Maybe I am wrong about needing to take NAC at night. I read somewhere that it helped clean toxins from the brain, and that the cleaning cycle runs at night. Also, I take the NAC with my Taurine as they complement each other. And Taurine helps reset the circadian clock, so that's another reason I take them before bed.
Thanks so much for this Bolt. I have been giving my husband NAC in the mornings and Taurine at night. He's also been taking vinpocetine first thing in the morning too. Looks like I'm going to have to change his schedule forthwith.
Are you sure the stuff is even safe or appropriate? And how even are you so certain that NAC is safe and appropriate and helps? I hear many conflicting things and I read many conflicting things about NAC. Also seen a conversation about a close, but perhaps not relevant, similarity to diacetyl, which is not exactly good for you.
Good point. I have a high school degree. Neither NAC or Vinpocetine are approved to treat PD. None of my protocols seems to be helping my condition. I have not been diagnosed with PD. I have REM Sleep Behavior Disorder which is considered pre-PD. I also have a sore left shoulder and sore left arm.
Hello, I must admit I have never heard of vinpocetine before! I looked it up on Google and it sure looks interesting.Please could anyone elaborate their routines and dosage and effects please?
Please could someone also recommend where to purchase. I live in the U.K.
Thanks for that - it’s something I’ve been thinking about. Can we do this systematically?Would like to take vinpocetine but struggling to find it- searche lead me to brain boosting supplements
I would say I have been taking Vinpocetine for about 3 months. No improvements yet. I have not been diagnosed with PD. I have REM Sleep Behavior Disorder, which is considered pre-PD.
Bolt_Upright I have been taking VPN in 40mg dosage, but had to look what time of day, lucky enough I take it at lunch!! Whew!Thanks again for the info 😁
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Update 2018: No significant increase of Glutathione (GSH) in Brain after oral administration with 6000mg NAC /day
Help! How do you time your eating with taking Sinemet?
Evidence for supplements?
Rytary and reduced absorption due to food 
