Is Parkinson's Disease an Autoimmune Diso... - Cure Parkinson's

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Is Parkinson's Disease an Autoimmune Disorder?

Bolt_Upright profile image

Is Parkinson's Disease an Autoimmune Disorder? journals.lww.com/neurotoday...

So I've been digging into Ashwagandha healthunlocked.com/cure-par... and have been learning you should not take Ashwagandha if you have an autoimmune disease. So the experts say. I have Hashimoto's, so I am taking a break from the Ashwagandha.

They also say the same thing about Ceylon Cinnamon (not to take if you have an autoimmune condition), but on that one I have seen conflicting reports so I am sticking with the cinnamon.

BUT THE POINT OF THIS POST IS: If Parkinson's ITSELF is an autoimmune disease, then we all may need to be careful of supplements that stimulate the immune system (this is why I previously cut out my beloved Zeolite).

Something to think about.

Bolt

26 Replies

I don't know that PD is definitely an autoimmune disease. My understanding is that the body is not producing normal amounts of dopamine. Years ago I was diagnosed with Lupus then with MS. Both are considered autoimmune diseases. I used the medications prescribed but also did self-medicating with AHT: Autohemotherapy. AHT has been used as an adjunct treatment for both diseases. Now I have PD and am doing AHT again.

Thank you for sharing kaypeeoh. That is really tough, Lupus, MS, and then PD. Good luck with the AHT treatment. I hope it helps.

gginto profile image
gginto in reply to kaypeeoh

So how you making out in general with these conditions together? You sound like you are quite active and doin ok...

kaypeeoh profile image
kaypeeoh in reply to gginto

For MS my understanding is abnormal monocytes will cross the BBB and attack myelin, the covering over nerves. AHT induces monocytes that will recognize the abnormal cells and destroy them. AHT can react to any abnormal cells in the blood: bacteria, virus, fungus and even cancer cells. For PD I wonder if alphasynuclein is treated as a foreign invader.

My approach is to look upstream and ask why. Did you handle something toxic on a regular basis that could have triggered these seemingly unrelated autoimmune diseases?

Parkinson's is beginning to look like an autoimmune disease too and anti-NMDA receptor antibody and neuroinflammation looks like the smoking gun.

These articles only scratch the surface of the link between autoimmune disease and NDDs.

Lupus [Anti-NMDA receptor antibody]

pubmed.ncbi.nlm.nih.gov/250...

PD [Anti-NMDA receptor antibody] pubmed.ncbi.nlm.nih.gov/183...

MS [Anti-NMDA receptor antibody]

nature.com/articles/nature0...

ALS [Anti-NMDA receptor antibody] pubmed.ncbi.nlm.nih.gov/245...

ALZ [Anti-NMDA receptor antibody] pubmed.ncbi.nlm.nih.gov/245...

I'm hopeful that we can all work together to change the trajectory of our individual illnesses, and modify the way they are treated and prevented in future generations.

SE

Higher free D-aspartate and N-methyl-D-aspartate levels prevent striatal depotentiation and anticipate L-DOPA-induced dyskinesia 2011 pubmed.ncbi.nlm.nih.gov/183...

"Current long-term treatment of Parkinson's disease is inadequate, and improved symptomatic and neuroprotective therapies are needed. Recent interest has focused on the use of antagonists of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor in Parkinson's disease. Abnormally increased activity of the subthalamic nucleus is postulated to play a central pathophysiological role in the signs of Parkinson's disease, and NMDA antagonists may provide a means of decreasing this activity selectively. Like dopaminergic agonists, NMDA antagonists can reverse the akinesia and rigidity associated with monoamine depletion or neuroleptic-induced catalepsy. Very low doses of NMDA antagonists markedly potentiate the therapeutic effects of dopaminergic agonists. There is evidence that the beneficial effects of anticholinergic drugs and amantadine may be mediated, in part, by NMDA receptor blockade. Moreover, NMDA antagonists provide profound protection of dopaminergic neurons of the substantia nigra in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and methamphetamine models of Parkinson's disease. The clinical use of NMDA antagonists may prove useful in Parkinson's disease to treat symptoms and retard disease progression."

Memantine is a safer choice than amantadine, from my personal research. But please validate for yourself.

SE

Do you have an opinion on Huperzine A

Do you have an opinion or info on Huperzine A? It’s an over the counter NMDA antagonist.

pubmed.ncbi.nlm.nih.gov/115...

Good find! I was trying to find a natural Memantine product.

I have been reading about it and watching videos on it and it looks good! I think I posted about it? I look forward to your opinion. We are adding L-Serine to my Dads protocol.

Good luck. I hope it helps. What dosage of L-Serine? I see in the trial they are using 15 grams twice a day. That's a lot. I found the $82 a kilo, which at 30 grams a day would be 33 day's worth.

I suggested omitting cinnamon in the case of auto immune disease based on my observation it aggravated some pre-existing inflammation in my body and based on an animal study showing a similar result outside the brain. Be that as it may, whether or not one regards Parkinson's as "autoimmune", it is my observation that cinnamon has really helped my Parkinson's, plus there is a study showing cinnamon helps alleviate Parkinson's in a good animal model. For details see:

healthunlocked.com/cure-par...

I just finished my cinnamon tea! I believe in it. I also believe Ceylon Cinnamon is GOOD for autoimmune diseases:

Can cinnamon spice down autoimmune diseases? 2020

ncbi.nlm.nih.gov/pmc/articl...

CONCLUSION

In spite of extensive research, there are no effective treatments or cures for autoimmune conditions. Available NSAIDs and immunosuppressants only control the symptoms of autoimmune diseases temporarily. Some monoclonal antibodies (e.g. Natalizumab, Vedolizumab, Alemtuzumab, Rituximab, etc.) have also been approved for controlling some autoimmune disorders. Steroids are used to attenuate the flare of different autoimmune conditions when other treatments fail. However, in general, these treatments exhibit a number of side effects including fatigue, nausea, headache, joint/muscle pain, gastrointestinal disorders, immunosuppression, lung infection, breathing problems, wheezing, urinary tract infection, vaginitis, opportunistic viral infections like progressive multifocal leukoencephalopathy, etc. Therefore, it is important to identify a safe, effective and economical therapeutic option for autoimmune disorders.

Cinnamon, a natural herb commonly used to spice up the delicacy of different cuisine, has a long track record of human use without any toxic incidence. It can be taken orally, the least painful route, and after oral intake, it is metabolized into NaB, the active compound and the FDA-approved drug for UCD and NKH. Similar to cinnamon, NaB can be also taken through food and drinking water or milk. Since cinnamon and its metabolite NaB upregulate anti-autoimmune Tregs and Th2, suppress autoimmune Th17 and Th1, inhibit inflammatory infiltration, and reduce the expression of pro-inflammatory molecules, cinnamon and NaB may have therapeutic importance in different autoimmune disorders (Fig. 1). Although cinnamon has been tested in human rheumatoid arthritis and TIDM and different rodent models (Table-1), further clinical trials at appropriate doses are required to understand the beneficial effect of this complementary and alternate option in different autoimmune disorders.

Very interesting. This report shows improvement in animal models of both rheumatoid arthritis and inflammatory bowel disease from cinnamon use. I shall update my report to include the results of this work.

Years ago I was diagnosed with MS. I took weekly IV infusions of Natalizumabi, AKA Tysabri, for two years. The only neurologic sign I had was smelling things that weren't real. I could always tell when it was about time for my next treatment because the fake scents were back. Eventually they stopped coming back and I quit the injections. A small number of people with MS have gotten over the disease. Some doctors say that doesn't happen. Instead they're on extended remission but eventually the signs come back. I knew of two people on an MS website who hadn't had a recurrence in ten years.

MS is diagnosed on an MRI, Brain lesions are seen in spots on the brain. Especially periventricular and in the cerebellum. These lesions are areas of vascular leakage within the brain. I still see an MS specialist once a year. So far no recurrences on MRI in the past three years.

List of autoimmune diseases found on a internet search

autoimmuneregistry.org/the-...

I would suggest a careful distinction between 'autoimmune disease' and 'inflammatory process' -- the latter is a definite factor in PD, but need not indicate the presence of the former.

And my impression is that the definition of what constitutes 'autoimmune disease' is rapidly changing and becoming blurred as the role of inflammation becomes better known in relation to many conditions previously thought to be unrelated to each other.

My two cents' worth. YMMV.

I take Ashwagandha to much makes me itch. I like KSM-66, it clears my thoughts, normal extract doesn't.... I read somewhere Ashwagandha can reverse PD.

Bolt_Upright profile image
Bolt_Upright in reply to Gcf51

Withania somnifera shows ability to counter Parkinson's Disease: An Update

symbiosisonlinepublishing.c...

Just came across stuff on LRRK2 and autoimmunity; LRRK2 expression is upregulated in:

lupus - translational-medicine.biom...

scleroderma (but not rheumatoid arthritis) - pubmed.ncbi.nlm.nih.gov/311...

I believe all NDDs are autoimmune, mine is. I know how you can find out if you are positive for NMDA receptor antibodies. This is associated with glutamate excitotoxicity and neuroinflammation found in virtually all NeuroDegenerative Diseases.

I'm not going to publicly share where to get the test because of the risk of having open access restricted. Message me directly.

SE

Great question Bolt, I am stating to wonder this myself. I have been researching stealth infections and those bastards are very real and potentially the cause of a huge amount of auto immune failures.

I'm actually wondering if the PD symptoms are a manifestation of a broken down Immune system, and if you were to strengthen it would , over time ease of the symptoms.

I have been researching the carnivore diet and for whatever reason it really strengthens the Immune system.....I do think that this maybe a very potential rabbit hole worth going down

I have been researching this as well. Mikhaila Petersen is a great info source. Higher meat protein intake is associated with a shorter lifespan and all cause mortality. But, that is so generalized. Doubt they are eating wild caught salmon. I think there is a big difference though between reducing an autoimmune response and strengthening the immune system. Auto immunity is about an overactive response where the body attacks itself whereas strengthening the immune system is desireable obviously for avoiding illness.

It has been hypothesized (I’m trying to remember which doctor said this) that the protein clumping is an autoimmune response. So the proteins arrive on the scene but are not the culprits.

Hey Matcharoe it certainly Is a interesting subject, I have researched Mikhailia Petterson and her case is very interesting to say the least. There are heaps of other interesting people testifying that the carnivore diet has repaired their immune system. It's just food for thought but very interesting food for thought

Please keep us updated!

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