"You can't untie a knot
without knowing how it is tied."
"It is the same to cut it as to untie it."
Alexander the Great, Aristotle's pupil
(according to the account of Curtius Rufus)
(In addition to greeting the HealthUnlocked community and thanking you for everything I am learning here, I would like to tell you that the book I am writing now is going at a good pace.
The passage through this community has been very, very fruitful.)
We could say that Parkinson's is a mystery hidden behind a riddle, itself hidden behind an enigma. A puzzle, a labyrinth... until we manage to see it as it is. Then we perceive light, colours, fresh air where before everything was gloom, a grey atmosphere with the smell of old hospital disinfectant.
As researchers, or rather amateur scientific detectives, we have observed that what prevents Parkinson's is the same thing whose absence is reflected in autopsies. And in turn, the very thing that slows down the disease and determines the severity of the symptoms.
I would like to recommend here two excellent articles by the American neurologist David Perlmutter from 2013 and 2015:
What I Wish Everyone Knew About Parkinson's Disease.
Parkinson's Disease-Treat the Fire, Not the Smoke.
Instead of choosing ONLY the cold path of the Laboratory, the synthetic and the patentable, turning our backs on Nature, let us take the BEST OF BOTH worlds: the Laboratory and Nature, because without anti-Parkinson's foods, without medicinal plants, spices, phytochemicals and other natural treasures, such a powerful adversary, with so many facets and forms, can never be defeated.
The Gordian knot of Parkinson's cannot be solved directly because of its complexity (which attracts, traps and drags everyone to the bottom of the sea like the Maelstrom whirlpool). Someone, like Alexander the Great millennia ago, must have the determination to cut it out with a sword. This, translated into more understandable language means, to consider without too many prejudices all that we have and works (in spite of "studies to the contrary") and to act... And not wait any longer.
Natural antioxidants against oxidation (Fahn)
Natural anti-inflammatories against neuroinflammation (McGeer).
Iron and aluminium chelators against their accumulation (Blaylock).
Mitochondrial energy boosters (Phillipson).
Liver protectors (Borah).
Restorers of sleep and pineal/extrapineal melatonin (Pierpaoli, Reiter).
The Parkinsonian world is made up of three realities: the patients (or the disease), the treatments and the world that has grown up around these two (specialist doctors, associations and therapists, foundations, pharmaceutical industry, insurance, etc.).
For some mysterious reason, each "actor" in this drama lives in his own bubble within the Parkinson's labyrinth, which shows a facet of himself to each person who enters his territory (patient, family member, doctor, researcher...). And there are many veils that prevent us from seeing things as they are. As in some science fiction films, it seems as if Parkinson's defends itself by trying to take over our minds and lives, and it does so by altering our perception, similar to what happens in nightmares (our mind becomes confused, we move with difficulty, we are assaulted by a certain paralysis when it comes to seeing, thinking and doing...).
Once again, history is a teacher of life and we could say that it is also medicine, through the information that leads to rediscovering forgotten, hidden treasures.
Can historical knowledge be the beginning of a Copernican revolution, of 180 degrees in the treatment of a disease?
And the answer is a resounding yes: Del Rio Hortega in 1919 on Alzheimer's and Manfred Karobath in 1971 on Parkinson's...? Microglia, neuroinflammation in dementia; multiple deficiencies in addition to dopamine in "paralysis agitans"?
Cutting the Gordian knot is treating the mitochondria. Years later, it is also reversing the iatrogenesis. It is no longer just Parkinson's...
In my humble opinion, Parkinson's has been unravelled in the studies of Fahn, McGeer, Karobath, Phillipson, Patel, Borah, Aoyama, Espay, etc.
In the past (the last five decades) and in other cultures (centuries and millennia of testing and adjustment), sufficient clues to the disease are possibly to be found.