Hidden clued me into quercetin and fisetin, And LAJ12345 just had quercetin on their list of Mucoactive natural products healthunlocked.com/cure-par... and laglag and SilentEchoes had some great information at healthunlocked.com/cure-par...
I started looking at these from the angle of: Targeting senescent cells: approaches, opportunities, challenges ncbi.nlm.nih.gov/pmc/articl... . There are challenges (like where do the dead cells go?).
Anyway, I found this trial "Senescence in Chronic Kidney Disease" clinicaltrials.gov/ct2/show... and they are testing Dasatinib against Quercetin. The interesting part is the protocol for Quercetin: take four 250 mg capsules daily (total 1000 mg daily) for 3 consecutive days.
So... this does not seem like an "every day" type of supplement. At least not for the purpose of removing senescent cells. Seems more like a "hammer those cells for 3 days at 1000 mg" type of thing.
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Dr Green believes in treating aging using all three: 100 mg dasatinib for three days, 1,000 mg of regular quercetin for three days, 1,500 mg of regular fisetin for three days.
Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Adults (AFFIRM-LITE) clinicaltrials.gov/ct2/show... Fisetin 20mg/kg/day, orally for 2 consecutive days
Senolytic Drugs Attenuate Osteoarthritis-Related Articular Cartilage Degeneration: A Clinical Trial clinicaltrials.gov/ct2/show... Fisetin 100 mg capsules (~20 mg/ kg/ day) will be administered orally for two consecutive days (days 1 and 2) followed by 28 days off. A second course will be given for two consecutive days (days 31 and 32)
Check out the interviews with Dr. Green on Modern Healthspan.
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