I am in a new rabbit hole. Somebody over on FB posted that their dad with PD took Ivermectin every day for 8 months and his PD is gone. He is not on no drugs and no supplements. Like all of us, I am vulnerable to these type of grand claims. So I started investigating Ivermectin and PD and so far I have found NOTHING on Ivermectin. BUT I did find something.
Ivermectin is an anti-malaria drug (Edit: Actually, Ivermectin is not an anti-malaria drug. Thanks kaypeeoh ). I happened to also be researching PGE1 and PGA1 healthunlocked.com/cure-par... and came across synthetic Nurr1 agonists and found more anti-malaria drugs. So now I am looking at anti-malaria drugs and PD and finding a lot:
For one, I just had my 10 mg of Methylene Blue for the day. Anti-malaria drug.
Here are some more (I decided to put MB on the list also). I will create a reply with more information for each of these:
Amodiaquine (AQ)
Artemisinin
Chloroquine (CQ)
Hydroxychloroquine (Plaquenil)
Methylene Blue
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"Current therapeutics for PD rely on medication or even surgery for deep brain stimulation with electric currents to increase dopamine levels in PD patients’. Professor Kwang-Soo Kim, a leading expert in Parkinson’s disease noted, “However, these pharmacological and surgical treatments address the patient’s symptoms, such as to improve mobility functions in the early stages of the disease, but the treatments cannot slow down or stop the disease process. Backed by various lines of scientific evidence, Nurr1 is known to be a potential drug target to treat Parkinson’s. Despite great efforts from pharmaceutical companies and academia, no one has managed to find a molecule which can directly bind to it and activate it, except for us.”"
More than anti-malarial agents: therapeutic potential of artemisinins in neurodegeneration 2019 ncbi.nlm.nih.gov/pmc/articl...
"Artemisinin, also called qinghaosu, is originally derived from the sweet wormwood plant (Artemisia annua), which is used in traditional Chinese medicine. Artemisinin and its derivatives (artemisinins) have been widely used for many years as anti-malarial agents, with few adverse side effects. Interestingly, evidence has recently shown that artemisinins might have a therapeutic value for several other diseases beyond malaria, including cancers, inflammatory diseases, and autoimmune disorders. Neurodegeneration is a challenging age-associated neurological disorder characterized by deterioration of neuronal structures as well as functions, whereas neuroinflammation has been considered to be an underlying factor in the development of various neurodegenerative disorders, including Alzheimer’s disease. Recently discovered properties of artemisinins suggested that they might be used to treat neurodegenerative disorders by decreasing oxidation, inflammation, and amyloid beta protein (Aβ). In this review, we will introduce artemisinins and highlight the possible mechanisms of their neuroprotective activities, suggesting that artemisinins might have therapeutic potential in neurodegenerative disorders."
"Challenges for Use of Artemisinins in Neurodegeneration
Although artemisinin seems to be a pluripotent drug with possible clinical value in anti-malarial, anti-tumor, anti-inflammatory and anti-neurodegenerative roles, there are potential pitfalls (Yuan et al., 2017). In contrast to short-term high-dose artemisinin treatment against malaria, long-term treatment with low-dose artemisinin has generally been investigated for treatment of other diseases (Wang et al., 2015). However, long-term low-dose exposure to artemisinin might induce free radical scavengers that can destroy the vulnerable endoperoxide bridge structure within artemisinin (Sun and Zhou, 2017). Furthermore, unexpected metabolic dysfunctions or other abnormalities, including neurotoxicity, or genotoxicity due to sperm DNA damage, might also emerge upon excessive artemisinin use (Singh et al., 2015). Therefore, the effects of artemisinin on neurodegeneration, either positive or negative, should be assessed and thorough long-term toxicity testing is performed to ensure safety at the appropriate dose."
Artemisinin Prevents Glutamate-Induced Neuronal Cell Death Via Akt Pathway Activation 2018 frontiersin.org/articles/10...
"Artemisinin is an anti-malarial drug that has been in use for almost half century. Recently, novel biological effects of artemisinin on cancer, inflammation-related disorders and cardiovascular disease were reported. However, neuroprotective actions of artemisinin against glutamate-induced oxidative stress have not been investigated. In the current study, we determined the effect of artemisinin against oxidative insult in HT-22 mouse hippocampal cell line. We found that pretreatment of artemisinin declined reactive oxygen species (ROS) production, attenuated the collapse of mitochondrial membrane potential induced by glutamate and rescued HT-22 cells from glutamate-induced cell death. Furthermore, our study demonstrated that artemisinin activated Akt/Bcl-2 signaling and that neuroprotective effect of artemisinin was blocked by Akt-specific inhibitor, MK2206. Taken together, our study indicated that artemisinin prevented neuronal HT-22 cell from glutamate-induced oxidative injury by activation of Akt signaling pathway."
The correlation between Toxoplasma gondii infection and Parkinson’s disease: a case-control study ncbi.nlm.nih.gov/pmc/articl...
"Although there is high level of anti-Toxoplasma IgG antibody in Parkinson’s patients which reflects chronic Toxoplasma infection; we couldn’t detect any statistical association between latent toxoplasmosis and Parkinson’s disease. Further studies such as cohort study would be helpful to assess the exact impact of T. gondii as the infectious agent in the etiology of Parkinson’s disease."
"Seems like you can't take this stuff long term. Maybe."
I think we should be looking at phases of treatment based on what we hope to achieve. Like all things in life, some treatments are for a season and others are for a lifetime.
You wouldn't continue with chemotherapy indefinitely after achieving remission. In some ways supplements are a natural form of chemotherapy.
Thoughts:
1. Arrest inflammation and block the neurodegenerative cascade
2. Detoxify
3. Rebuild and regenerate
4. Homeostasis, balance hormones
5. Maintenance, healthy lifestyle, emotional health, practice gratitude - protect your peace!
My husband took this supplement when he had Lyme Disease for his fatigue. Successfully treated the fatigue. Only can be on this supplement for a short period of time.
One of my favourite herbalists of the early 20th century was Juliette de Bairacli Levy. Her herbal talks alot about the wormwood plant. Must find her again and find out...my library is all over the place as im going through reforms...hopefully ill find her. I love herbs. They sre a great gentle way to experiment
"Current therapeutics for PD rely on medication or even surgery for deep brain stimulation with electric currents to increase dopamine levels in PD patients’. Professor Kwang-Soo Kim, a leading expert in Parkinson’s disease noted, “However, these pharmacological and surgical treatments address the patient’s symptoms, such as to improve mobility functions in the early stages of the disease, but the treatments cannot slow down or stop the disease process. Backed by various lines of scientific evidence, Nurr1 is known to be a potential drug target to treat Parkinson’s. Despite great efforts from pharmaceutical companies and academia, no one has managed to find a molecule which can directly bind to it and activate it, except for us.”"
Edit June 3rd 2022: Yikes! According to RXlist.com you should NOT take Methylene Blue and Levadopa: rxlist.com/drug-interaction...
"methylene blue oral and levodopa oral
methylene blue oral and levodopa oral both increase affecting serotonin levels in the blood. Too much serotonin is a potentially life-threatening situation. Severe signs and symptoms include high blood pressure and increased heart rate that lead to shock. Combination may cause severe harmful effects. If methylene blue must be taken, stop taking the serotonergic drug until 24 hours after finishing methylene blue or after 2 weeks of observation for side effects."
Hello Bolt ~ You may have seen this ~ and I confess that I am in the process of reading this article which in essence means I haven’t completely read it, but it appears to have some interesting information.
Interesting, wonder if has anything to do with gut dysbosis which some researchers belief impacts PD development, as our gut is our 2nd brain. Also wonder if the ivermectin improvement is temporary. I have read IVM is used a theraputic for long-covid.
So, I’m wondering ~ if the PD medical researchers are truly sincere in finding a “ cure” or something truly helpful ~ why are they not perusing these anti malaria drugs with a vengeance? Are they sincere or money hungry….
I was troubled to read they are looking to develop new formulations to test. I hope this is not because there is no money in these old drugs. I will try and think the best.
And since ivermectin has antiviral properties it's reasonable to assume that it can help some PWP to reduce viral load and help with slowing/stopping disease progression.
Good question and I wish I had an answer. I can only tell from my experience that when I get sleep deprived next day I develop a cold sore on my mouth which is a manifestation of latent virus. Also, I had a tick bite and was diagnosed with Lyme which is not viral but can be latent infection and also ticks can carry a host of other pathogens that I may not be aware of.
There are ways around this to reduce your chances but inevitably a small % of people will get the rash. It only happens once and then you're good to go with continuing with Lomatium. Look at BarlowHerbals, it's a small family owned business in Utah.
Yes, I forgot to mention that it is just one time rash, thank you for clarifying that. I've used lomatium in the past (other brands than Barlow which was more expensive at that time) and had no problems.
Vitamin C can block the blue. My recollection is that you mix Vit C in with MB and let it react for a while before you take it, especially helps with urine color 😊
Thanks SE. He takes it in OJ, but doesn't let it react. Good to know, will try to let it react for a while. See if makes a difference. Are you taking MB?
I focus most of my attention on things that lower viruses, viral titers, iron chelation, increased blood flow to the brain, fixing leaky gut, and fixing gut dysbiosis.
(For those not aware, I have not been diagnosed with PD. I have REM Sleep Behavior Disorder, a sore left shoulder and leg, and a few other symptoms).
It looks like you on the right track Bolt. May I ask - how do you monitor your viral titers, do you run some test? And also I am curious what dose of Ivermectin was used during 8 months treatment mentioned on FB?
So the guy on FB was kind of sketchy. He posted but then did not answer basic questions like yours. He just directed people to a Telegram page to listen to testimonials. I am still searching on Ivermectin but not getting my hopes up.
Ivermectin is available without prescription in other parts of the world and you can order it online from overseas pharmacies - that's what I did. However, there is a list of covid treating doctors on FLCCC website who you can contact for telemedicine appt.
genericcures.com/ I've been taking it prophylactically according to FLCCC I-MASK protocol (0.2mg/kg body weight) for the past several months with different frequency between 2x/week to 1x/every 3 weeks depending on the number of covid cases in our area.
I sure did. No I didn't look for another on line pharmacy. Buying it is on my list-to-do, Faridaro. I had hubby start umPEALut. He is doing fine on this supplement so I will wait a few weeks to see more results and will go from there. Ivermectin is good to have it now a days!
The tablets come in 3, 6 and 12 mg. You need to figure out the dosage according to your body weight and if having covid symptoms it can be doubled according to FLCCC guidelines.
I understand. Unfortunately I don't know about dosing for PD (if someone does would love to hear from them.) Looking at covid dosing gives some loose guidelines about IVM safety.
Hi,My ND prescribed Ivermectin for me when I might have had (a virus?) covid? Very mild symptoms overall, just a-1/2 days of a fever and felt bad, otherwise just fatigue. Lasted a week. Anyway, dose was 3 times a day, from a compounding pharmacy, liposomal 12 mg. For 5 days followed by 1 capsule twice a week after that. I weigh 110. There were 30 capsules total. Hope this helps. I have PD and this is first time I've heard anything about it being used for PD. Always encouraging to hear about meaningful research on PD.
Thanks for sharing your experience. Yes, this is very first time I've heard about ivermectin been used for PD as well. Not sure if this information is meaningful but you never know - years ago someone in my family got rid of painful plantar fasciitis by using some Asian stuff for several months while the doctor declared its not curable and the only option was a surgery which couldn't guarantee that it wouldn't return later.
I believe in those "ancient healing secrets" so to speak, it was what they knew and had then. As well, I believe in things I cannot see (such as what is known as "energy medicine"). I also read recently that although the conventional medical system tells us PD is incurable, we should "not accept that". Not to put sugarplums in our head but to refuse to accept something because it's the common belief or accepted to be truth. Miracles do happen, so never give up.
I listen to Danny on dirt road discussions and he has used ivermectin 1.87 paste for 5 1/2 years and has been cured of Lyme disease and early Parkinson’s. Ivermectin pills are good but he says it takes much longer to heal. He’s simply offers information to help us. He is not selling us anything but restoring our health back and riding our body of parasites that cause all illnesses and diseases. He feels we waste money on snake oil remedies and all these companies when ivermectin takes cure of everything and part of the Hidden patents to heal us that the government has been hiding for decades according to my inside source.
Did by any chance Danny share his Ivermectin protocol for PD? It would be nice to know although i am skeptical of claims that there's something that can cure everything. Many diseases can be caused by parasites but some are caused by exposure to toxins, radiation, etc.
Tablets come in 3 sizes - 3, 6 and 12 mg. You can choose either one or a combination of each. I ordered 3mg and 12 mg tablets because someone in my family would require a 15mg dose based on body weight.
Sorry to change subject but want to make sure you see this Are you familiar with this doctor? I have been listening to him and learning a lot about the brain and PD but his speciality is actually Hashimotos.
You can leave it here, but I think more people will see it if you make a new post. So much information about inflammation and thyroid. I know I am tweaking my protocols after listening. Thanks again.
He's fantastic, incredibly knowledgable! Not taking new patients unfortunately, although sometimes spots open up. He puts out a lot of free info about brain health.
Ivermectin may have anti-viral properties, see recent controversy over it's use for covid (probably effective, but massive uphill battle against pharma industry). That said, probably not effective against malaria, given how ivermectin is handed out like candy in many tropical developing nations, pretty sure someone would have noticed by now!
Interesting! Silver nanoparticles reduce brain inflammation and related neurotoxicity through induction of H2S-synthesizing enzymes 2017 pubmed.ncbi.nlm.nih.gov/284...
Whatever you do don’t take Larium/mefloquine . I took it once for an overseas tropical holiday and it permanently damage my memory and ability to study and temporarily for a few months affected my ability to concentrate. I found myself driving on the wrong side of the road and got lost in a small shop and couldn’t get out.
Lithium, too. I use just 10mg OTC to prevent frustration. I got a small improvement in tremors at this dosage. Prescription dose is closer to 500mg, have not tried it. ncbi.nlm.nih.gov/pmc/articl... took 600mg Swanson NAC 3x/Day and felt better. Repeated-Dose Oral N-Acetylcysteine in Parkinson's Disease pubmed.ncbi.nlm.nih.gov/289...
YIKES! I read the NAC study. It was 3000 mg NAC twice a day and showed people's symptoms got worse on that dose: Repeated-dose Oral N-acetylcysteine in Parkinson Disease: Pharmacokinetics and Effect on Brain Glutathione and Oxidative Stress ncbi.nlm.nih.gov/pmc/articl...
"NAC’s primary mechanism of action is hypothesized to be through its deacetylated product Cys, which is the rate-limiting substrate for GSH synthesis. A 4-week, high oral NAC dose regimen resulted in significant increases in Cys, and the blood antioxidant measures: GSH/GSSG and catalase. However, it did not reduce the measures of oxidative damage in the blood: 4HNE and MDA. Additionally, NAC did not increase GSH brain concentrations. Finally, this study showed that some people with PD had worsening of their Parkinsonian symptoms with high doses of NAC that resolved with discontinuation of therapy."
I take 1200 mg of NAC (with Taurine) at night. I may need to re-evaluated that.
This study aims to determine if one of three low doses of lithium therapy for 6 months can engage one or more blood-based therapeutic targets implicated in Parkinson's disease (PD) pathophysiology. Results of this study will help to determine if lithium therapy is worthwhile to further investigate as a potential disease-modifying therapy in PD, the optimal dose to study and the optimal PD subgroup most likely to benefit from lithium therapy.
Thank you Bolt for clarification. Hope lithium will work for you. If you hadn't seen Dr. Mischley's thesis on lithium you may want to check it out:digital.lib.washington.edu/...
Hm, interesting! It says the trial completion is in July, so hopefully we’ll have results soon. (We lived in Buffalo for a long time, and Dr Gutoso has a pretty good reputation)
Making statements claiming a person was cured from PD is not just a simple statement. The medical profession all agree no cure for PD and millions of suffers anxiously await for a cure.A doctor would not write prescriptions without reason to believe it will help the patient and it is medically sound. The article lists several Anti-malaria drugs for treatment a doctor can not treat PD with Anti-malaria drugs no more than drugs used for other sickness .
The PD suffer is captive of a medical profession that will not permit this type of treatment. Why the answer would be censored and not allowed to be public.
I have read a lot of research and much is very promising but without funding and support it is never proven that it can help millions , so this explains why PD has no cure.
Yes, I was hesitant to even mention the Ivermectin story, PD sufferers are so anxious to believe, but that story led me here so I wanted to be transparent (although the PGE1 and PGA1 story also led me here).
Just think if they would spend the $40 billion for Ukraine on PD instead.
The reason Ivermectin and other anthelmintics have broad affects against cancer, viruses, parasites and neurodegenerative disorders is because they use the same biological pathways to induce oxidative stress and reactive oxygen species that triggers inflammation.
I'm looking specifically at Albendazole 400mg + Ivermectin 12mg as a therapy for ALS.
I owned the domain degoogled.com but let it expire (and somebody grabbed it) when I started having medical issues. I had planned on selling it eventually and making a fortune
But now I know I can't deGoogle anyway. Google is too strong.
Well... I have tried DeFacebooking too. It is pointless. Or more accurately: Resistance is Futile.
Very interesting! Albendazole activates Nurr1 also. Hypoxia-inducible factor 1 alpha and nuclear-related receptor 1 as targets for neuroprotection by albendazole in a rat rotenone model of Parkinson's disease pubmed.ncbi.nlm.nih.gov/314...
"the present study suggests that ABZ exerts a neuroprotective effect in a rotenone-induced PD model associated with HIF-1α and Nurr1 activation and thus may be a viable candidate for treating PD"
And Albendazole is a dewormer, much like Ivermectin. I hope we are on to something here. Good luck and much thanks.
The more important part of that link is the Hypoxia-inducible factor 1 alpha. It's the trigger for neurodegenerative cascade caused by asphyxiants, like cyanide and organophosphate pesticides.
"We identified the antimalarial drug amodiaquine (ADQ) in our initial screen of FDA-approved drugs, but we hesitated to further pursue it because of reports that active doses of ADQ cause hepatotoxicity resulting from the formation of a p-aminoquinone during metabolism in the liver. To reduce potential for toxicity, we synthesized and evaluated a known analog of ADQ, isoquine (ISQ), which eliminates the reactive electrophilic quinoneimine intermediate associated with ADQ toxicity by changing the position of its amino group. ISQ cannot form the quinoneimine intermediate and, thus, has been reported to have greatly reduced toxicity."
So we're looking for a safer, less toxic antimalarial/antiparasitic. Ivermectin fits this description.
You can go up higher with Ivermectin. FLCCC recommends 0.6 – 1.0 mg/kg day orally, and is relatively safe at a higher dosage with less side effects. You can probably shoot for 12mg three times a day easily, and still stay below the 1mg/kg higher dose range.
It's expensive, maybe do a higher dose short term and maintenance dose coupled with albendazole 400/12. Hope I continue to have access to these anthelmintics 🙏🏻
They used to be so dirt cheap but now they do hover around $1/pill at least even through overseas pharmacies after the Covid. I did a 10 days protocol along with a friend of mine fighting prostate cancer under Dr. Simon Yu, the author of "Accidental Cure," and personally felt absolutely nothing with no side effects. Just another hole to plug.
"The success of ivermectin in driving two of the most devastating and disfiguring neglected tropical diseases (NTD) to the brink of elimination has been well documented. The drug also bestows immeasurable non-target benefits, increasing the health and socioeconomic prospects of all communities where mass drug administration (MDA) has been carried out. Ivermectin kills a variety of parasites and insects, including the Anopheline vectors of malaria parasites. In view of long-standing MDA programmes, increasing attention is now being paid to the potential offered by re-formulating and re-purposing ivermectin to function as a feed-though mosquitocidal tool. This will provide a comprehensively beneficial weapon, for the anti-malarial armamentarium, as well as for probably improving the impact on existing target diseases. Prospects currently look highly promising, especially as the drug is already proven to be extremely safe for human use."
I replied yesterday. The Chat in HU is notoriously slow. I said you should join this FB group facebook.com/groups/1420381... and search for Ivermectin and you will see a topic that starts with "Kratom". It is in that thread.
"the anthelmintic drug ivermectin has also recently been described as potent inducer of ubiquitin-dependent mitophagy (Table 1), working via a mechanism independent of PINK1 and Parkin potentially involving other E3-ligases, TRAF2, cIAP1, and cIAP2 (149) (Table 1)."
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Does anyone have an opinion on the use of Vitamin B1 for treating PD?
Good News - Drugs to address chronic inflammation and PD - NodThera
ELON MUSK gets FDA approval for 'BRAIN CHIP' to treat PD and other neuro conditions!
