Experiences with

Dasatinib

Of these “senolytic” drugs, currently the best-characterized are dasatinib (D) – an FDA-approved medication for treating certain types of leukemia – and quercetin (Q), a flavonoid compound naturally found in many fruits and vegetables.

Hi, Dad’s oncologist has stopped the Erlotinib as last scan in Jan showed tumour growth. Private Liquid biopsy result just back, mutation EGFR p.L747_T751de. No treatment offered by NHS, oncologist thinks will be more harmful to dad but how does he know for sure? I read some PubMed data that restarting

New paper from Spain [1]. "... we will review those strategies and drugs that are able to resensitize cancer cells to previously used treatments through the use of "hinge" treatments with the objective of obtaining an oncological benefit. "Some examples are: [i]bipolar androgen therapy (

Whatever the case, this research provides one more reason to be cautious about jumping into the deep end when it comes to senolytics, esp. for the combination of dasatinib and quercetin.

started my treatment of dasatinib, will wait to have toxicities checked in 2 weeks. this drug is $15,000. A month! How can any medication cost that much?

Trastuzumab deruxtecan (T-DXd) was associated with higher response rates and longer survival than capecitabine-based regimens for [i]third-line treatment of patients with HER2-positive metastatic breast cancer [/i]previously treated with trastuzumab emtansine (T-DM1), according to a study presented

dosages in the trial: Arm 1 (which I'd be in): Hydroxychloroquine 600mg twice daily Metformin 500mg daily for 7 days, then increase to 1000mg daily Sirolimus 0.5mg daily Arm 2: Hydroxychloroquine 600mg twice daily Metformin 500mg daily for 7 days, then increase to 1000mg daily Sirolimus 0.5mg daily Dasatinib

My chosen senolytic regimen is Dasatinib 100mg, plus Quercetin 1600 mg, plus Fisetin 1000 mg daily for just three days.  On the long drive back to Oregon, I had downloaded a new and very good science podcast called "The Joy of Why" by Quanta online magazine. Every episode was excellent.

He’s starting me onSprycel ( dasatinib) after my bone marrow biopsy, I did not realize that these are chemo meds either. anyone have any experience with these drugs?

These include: 1) Intermittent short courses of Dasatinib plus Quercetin. ( I take Dasatinib 100 mg daily for just 3 days combined with Quercetin 1000 to 1500 mg Quercetin for those three days.

Doxazosin, an alpha1-adrenoceptor antagonist, is used for the treatment of benign prostatic hyperplasia (BPH) and hypertension. Alpha-adrenoceptor antagonists also inhibit growth and induce apoptosis in malignant prostatic cells. The apoptotic activity is independent of their capacity to antagonize

Hello again everyone. I have just started on Tagisso which my doctor said is unlikely to work because my tumour doesn't have the right genetic 'make up'. But I live in hope, what else is there. He also said that if it didn't work there was nothing left. Over the past 2 years I have had Afatinib, immunotherapy

be a role for Dasatinib pre-CRPC?

A total of 13 side effects are stated as common – occurring in more than 10 % of patients using chronic D 100 mg/day – in https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/dasatinib See also https://www.mayoclinic.org/drugs-supplements/dasatinib-oral-route/

term=quercetin&draw=5&rank=39 and they are testing Dasatinib against Quercetin. The interesting part is the protocol for Quercetin: take four 250 mg capsules daily (total 1000 mg daily) for 3 consecutive days. So... this does not seem like an "every day" type of supplement.

Hi just an update Have stage 4 lung but seems to be stable last scan showed my hip has been nibbled so having to have 5 rounds of radiotherapy Got my last bit of welding tomorrow I don’t Know if anybody else has had diarrhoea but Iv been terrible even a biscuit ! Anyway I’m still taking afatinib and

I was diagnosed with stage 4 lung cancer in early 2020 and was given the targeted therapy Afatinib. This was initially most effective but gradually stopped working and so the cancer spread further in the lungs. I then had five consecutive radiotherapy sessions which reduced the size of the main tumour

Hi Iv been on 50mg afatinib now for 14 months though I struggle with the rash Iv got antibiotics if it gets too bad just wondering if if ever settles on it’s own

Hi, Has anyone taken Candilap? Anyone who knows about or has taken Lapatinib?

Hi there Can anybody recommend a makeup that is suitable for rash prone skin I am on afatinib 50mg and have a red face at the moment 🙈though I won’t wear anything while I have it but after it’s gone I would like to get some slap on.