Mannitol, Trehalose or Xylitol? - Cure Parkinson's

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Mannitol, Trehalose or Xylitol?

glenandgerry profile image
25 Replies

Which one is better? Have tried them all for my HWP with no discernable benefit, would like to try one of them again.....but which one......any tips or suggestions?

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glenandgerry
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25 Replies
blogger_7 profile image
blogger_7

I think the simplest way to answer your question is send you to a blog entry: silverliningsandparkinsons....

glenandgerry profile image
glenandgerry in reply toblogger_7

Thank you

You can not purchase Trehalose to ingest as far as I know? If someone knows otherwise that would be great.

glenandgerry profile image
glenandgerry

I bought it here in the UK (after reading what sunvox had to say about it in the Ataxia forum here on HU), Glen has been taking it but very irregularly for the past couple of months........just about to run out and wondering whether I should rather purchase mannitol again.

glenandgerry profile image
glenandgerry in reply toglenandgerry

Btw, I purchased from trehalose.co.uk

in reply toglenandgerry

Thank you! I will look in to acquiring itHave you heard about farnesol?

glenandgerry profile image
glenandgerry in reply to

No I haven't. What is it?

chartist profile image
chartist

Hi Gerry!

As far as I know, mannitol is the only one that has any semblance of testing in PwP and that is mainly anecdotal.

Trehalose is available at suppliers such as this :

swansonvitamins.com/swanson...

google.com/search?q=trehalo...

Art

glenandgerry profile image
glenandgerry in reply tochartist

Thank you Art. I seem to remember reading somewhere that Mannitol could be contra-indicated in some PWP with a certain type of gut bacteria.......does that 'ring any bells'?

chartist profile image
chartist in reply toglenandgerry

That is what I read about Trehalose acting to create a type of super C-diff, if I remember correctly, but I missed that about Mannitol.

ncbi.nlm.nih.gov/pmc/articl...

There are other studies showing that Trehalose does not cause this problem so it is a bit confusing :

pubmed.ncbi.nlm.nih.gov/331...

Mannitol is known for increasing butyrate in the gut if there are enough butyrate producing bacteria in the gut, but this is not the reason that Mannitol was first thought to be useful in PD. Butyrate also helps repair the gut mucosal barrier and endothelial cells helping to reduce gut permeability/leaky gut which is an inflammatory process that we don't need so mannitol is useful in that way.

Art

glenandgerry profile image
glenandgerry in reply tochartist

Thanks Art, that is very helpful but, as you say........confusing!

chartist profile image
chartist in reply toglenandgerry

Trehalose is a supplement that Joe/Sunvox used as part of his protocol as described in his profile.

Art

glenandgerry profile image
glenandgerry in reply tochartist

Yes, that was what originally prompted me to buy it for Glen to try. Sadly, he hasn't taken it regularly enough for me to ascertain any discernable benefit.

chartist profile image
chartist in reply toglenandgerry

I have a friend with PD who seems like Glen. If his wife isn't constantly twisting his arm to take his meds and supplements, he won't take them regularly. A bit frustrating!

Art

Despe profile image
Despe in reply tochartist

I hear you, Art. . .

Gioc profile image
Gioc

It would seem that the trehalose is very useful. Here a recent Italian research on LRRK2 and the G2019S mutation responsible for 10% of PD cases and the use of trehalose.

osservatoriomalattierare.it...

glenandgerry profile image
glenandgerry in reply toGioc

Thank you Gio......amazing that you found this!I've just ordered 1kg of mannitol but I'm still unsure which is better ie trehalose or mannitol. Maybe I will 'hedge my bets' and alternate between the two!

Gioc profile image
Gioc in reply toglenandgerry

… Or a good Italian ice cream. (given that trehalose is used at a maximum of 5% in ice cream instead of sucrose because it makes it more viscous) 😜😜😜.

P.S. I buy it in an ice cream shop from a friend of mine, it's cheap.

Missy0202 profile image
Missy0202 in reply toGioc

I can't access that link for some reason.... it says "forbidden" is it just me??

Gioc profile image
Gioc in reply toMissy0202

I do not know.Mysteries of the web. Hope you solved.

Bolt_Upright profile image
Bolt_Upright

Trehalose as a promising therapeutic candidate for the treatment of Parkinson's disease - 2019 ncbi.nlm.nih.gov/pmc/articl...

Neuroprotective Effects of Trehalose and Sodium Butyrate on Preformed Fibrillar Form of α-Synuclein-Induced Rat Model of Parkinson’s Disease - 2021 ncbi.nlm.nih.gov/pmc/articl...

I did find this article "Natural Compounds and Autophagy: Allies Against Neurodegeneration" frontiersin.org/articles/10... from 2020 that says you can't take Trehalose orally, but that confuses me because sunvox linked to ncbi.nlm.nih.gov/pmc/articl... seems to indicate taking 100 grams a day does make it into your blood.

There is also this article from 2017 Autophagy induction by trehalose: Molecular mechanisms and therapeutic impacts researchgate.net/publicatio... if you scroll down past the abstract it shows a bunch of citations with cool factoids.

glenandgerry profile image
glenandgerry in reply toBolt_Upright

Thank you for this in-depth reply Bolt. Did you download the whole paper from research gate? I haven't yet as I'm rushing off to work right now.

Bolt_Upright profile image
Bolt_Upright in reply toglenandgerry

I can't download from Researchgate as I am not a professional.

kevowpd profile image
kevowpd in reply toBolt_Upright

Professional supplement tester? 😜

Gcf51 profile image
Gcf51

I am about to order Trehalose... swansonvitamins.com/swanson...

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