More Bee Stuff: Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster - 2020

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The study showed that the administration of ethanolic extract of propolis (500 mg/mL) with levodopa (250 mg/kg) not only significantly prevented the motor impairment which has been associated with the long-term use of levodopa but also improved motor function.

The study also showed that propolis in combination with levodopa effectively increased catalase and reduced concentrations of reactive oxygen species in Drosophila melanogaster (Figure 2(a)–(b)). Since levodopa metabolism has been associated with reactive oxygen species [15, 16], findings in the study offer a novel option for use in integrative medicine i. e. use of levodopa and propolis to minimize on the side effects of levodopa therapy.