But I just saw the video, we get a lot of new people here, and I have some thoughts on this.
I'm also going to pilfer from the LAJ12345 comment on the thread and their link to "A Review of the Diagnosis and Treatment of Ochratoxin A Inhalational Exposure Associated with Human Illness and Kidney Disease including Focal Segmental Glomerulosclerosis" hindawi.com/journals/jeph/2...
If you scroll down to "9. Ochratoxin and the Brain" you will see things like "A single dose of OTA to Swiss mice was associated with significant oxidative damage in six brain regions—the cerebellum, hippocampus, caudate putamen, pons medulla, substantia nigra, and cerebral cortex" and "A dose-dependent increase in cytotoxicity was found in both cell types resulting from apoptosis and accompanied by a loss of mitochondrial membrane potential" and "Based on these data, the authors speculated that OTA may contribute to the development of neurodegenerative diseases such as Alzheimer’s and Parkinson’s in which apoptotic processes are centrally involved".
But that is not why I am posting. Scroll down to "13. Treatment":
1) Cholestyramine (prescription)
2) Charcoal
3) Clay
4) Zeolite
5) Licorice extract
6) Melatonin
7) Sauna
8) Antioxidants, including glutathione, are also likely to be helpful for their antioxidant and detoxification effects. Vitamins A, C, E and selenium are other potentially beneficial antioxidants that may be protective in their role as superoxide anion scavengers
"If elevated levels of urinary OTA are found, there are a number of safe treatments that should be considered to lower the body burden of this mycotoxin. The most important are the avoidance of further exposure and the use of the bile acid resin binding agent, cholestyramine, to decrease enterohepatic recirculation of OTA. Studies have shown that animals fed a diet of OTA plus cholestyramine had a significant shift of OTA from the plasma and urine to the stool, where it is presumably excreted bound to cholestyramine [74]. This will safely reduce the burden on the kidneys as cholestyramine is not absorbed systemically and remains in the gastrointestinal tract. Side effects, which are primarily limited to the gastrointestinal tract, must be considered as well as the timing of cholestyramine away from medications and vitamins, primarily fat soluble vitamins. Many patients tolerate the pure resin better than the commercial prescription prepared with sugar, artificial colors, and a number of additives. As a number of patients with kidney disease also have hyperlipidemia, cholestyramine could potentially beneficial for its lipid lowering effect.
Other potential sequestrant treatments include the use of charcoal which is included in the military textbook recommendations for exposure to trichothecene mycotoxins which has been associated with Yellow Rain exposure [77]. Clay and zeolite have been studied for their efficacy of mycotoxin binding in animals [78, 79] and likely have a use in human illness caused by mycotoxins including OTA.
The use of licorice extract and melatonin was mentioned earlier in this paper and require further study, but may offer a safe option for reducing the toxicity of ochratoxin. There is some evidence that sauna shifts the excretion of ochratoxin to sweat; however, use of sauna needs to be very carefully monitored, especially on initiation. Antioxidants, including glutathione, are also likely to be helpful for their antioxidant and detoxification effects [23]. Vitamins A, C, E and selenium are other potentially beneficial antioxidants that may be protective in their role as superoxide anion scavengers [22, 75]."
So out of these, I am using Zeolite, Melatonin, and Selenium. I've been considering adding Bentonite Clay. Had not really thought of Charcoal. Had not heard of Cholestyramine.
1) Cholestyramine (prescription)
2) Charcoal
3) Clay
4) Zeolite
5) Licorice extract
6) Melatonin
7) Sauna
8) Antioxidants, including glutathione, are also likely to be helpful for their antioxidant and detoxification effects. Vitamins A, C, E and selenium are other potentially beneficial antioxidants that may be protective in their role as superoxide anion scavengers
If my tight and sore left shoulder and arm was PD, maybe I could judge improvement there as showing my protocol is working. But most likely (I hope) it is mouse shoulder as I have been spending the last 20 years 12 hours a day with a mouse in my left hand.
And if the front of my left thigh would stop hurting, I might think that is improvement, but I sit cross legged about 6 hours a day with my right ankle resting on the top of my left thigh, so hoping that is not PD either.
I do have much better poop than I used to have. Usually a 3 or 4 on the Bristol chart. Never been like that since I was a kid.
This is so subjective, but since I added the Niacin 250 mg Time Released I have felt steadier. My fork does not seem to quiver. My fingers don't shake. I can pick up and shell pistachios. It had been getting so that when I picked up small things like pills or pistachios with my fingers there would be a little dance to stabilize the item between my fingers. That is not happening anymore. And when this started I was already feeling balance issues. Maybe all in my head. And now I don't feel those issues. I generally feel better lately.
If my depression would lift, I would be sure this is working.
And... I monitor my sense of smell. It kind of comes and goes. I was pretty happy tonight when I walked into the kitchen and could smell my wife's tuna salad she was making.
Zeolite Clinoptilolite is Pro-Inflammatory. That's Bad.
I am so stupid. I've been taking something that has probably been making me worse. And I have been evangelizing about it. So many report looked so good, but I was not smart enough to notice the finer details. Zeolite Clinoptilolite modulates immune responses. It up-modulates them (not what I expected).
So many places I read that Zeolite Clinoptilolite is anti-inflammatory. Can't figure out why they say that now. It is a superantigen and amps up the immune response:
sciencedirect.com/science/a... "As superantigens, zeolites are also responsible for the development of local inflammation, in which accumulated macrophages release large quantities of free oxygen radicals (Olanders et al., 2002). Besides reactive oxygen species, activated macrophages release tumor necrosis factor (TNF), which together with other cytokines and calcium compounds stimulates splenic T cells (Pavelic et al., 2002; Hu et al., 2013; Lamprecht et al., 2015)."
In 1984 Korkina et.al. showed that clinoptilolite particles cause hemolysis and macrophage toxicity (Kleiner, et al. 2001). Katic et al. (2006) showed that clinoptilolite can absorb the growth factors in cell media and inhibit the cell proliferation (Rivera, et al. 2005). These studies show that clinoptilolite, a kind of naturally occurring zeolite, has apoptotic, toxic and hemolysitic effects on living cells directly or indirectly. In addition to these investigations, it was found that silicates have the superantigen ability so that they can induce T cell apoptosis and may cause autoimmune diseases. Not only the T cells but also the alveolar epithelial and mesothelial cells can undergo apoptosis.
Both intrinsic and extrinsic pathways may be triggered by silicate particles (Aikoh, et al.1998, Hishumura, et al. 2006, Tomokuni, et al. 1997, Otsuki, et al. 1998, Otsuki, et al. 2000, Otsuki, et al. 2002, Matthew, et al. 2004). Ueki et al. (1994) and Aikoh et al. (1998) showed that silica; silicates and aluminosilicates act as nonspecific immunostimulators (like superantigens) (Aikoh, et al. 1998, Pavelic, et al. 2001). Also Allison et al. (1966) showed that pro-inflammatory macrophages were activated by fibrinogen silicate particulate. Silicates are the substances of which have Si ions in their structure. Clinoptilolite is that kind of substance but there was no any investigations carried out on zeolites or clinoptilolite for their effect on T lymphocyte apoptosis. In this study T lymphocyte apoptosis via clinoptilolite will be investigated, and then the pathways that can take role in apoptosis will be enlightened.
I'm so sorry for going down this path and especially for sharing it with others. This may explain my current issues with seborrheic dermatitis.
My hubby had very high levels of ochratoxin and worryingly mine came back even higher. No idea where from. No water damage in the house but I suspected our firewood may have had mold spores so this year we have avoided the fire and gone with electric heater instead. And we have an air purifier in his bedroom running continually. Our naturopath put him on 3 months of Toxaprevent and also chamomile extract for a while. There is a danger if it is excreted through the kidneys it can cause kidney problems apparently.
Medical Device to Strengthen the Gastrointestinal Wall Barrier. TOXAPREVENT® contains MANC® (modified and activated natural clinoptilolite). ... TOXAPREVENT® strengthens the intestinal wall barrier by effectively removing toxins and intestinal irritants from the intestinal tract.
I'm currently using cholestyramine -- I believe it requires a prescription. It's not nasty at all to take but tricky with PD as it has to be taken at lease one hour before or two after taking meds and supplements. It can also worsen constipation, so LOTS of water and if necessary Miralax. I also use charcoal (togrther with Cholest. to make timing easier), glutathione, sauna (not as often as I would like) and melatonin (I'm at around 20mg daily) and 3 gms vitamin C.
You can get your mycotoxins tested. Great Plains Laboratory has the best mycotoxin screen, I believe you can order it yourself, at around $300.
My Ochratoxin A is still high although it has come down since two years ago, still highish, but my mycophenolic acid (comes from Penicillum bacteria -- some strains of which are very toxic) which is immunosuppressive, is very high. Also Citrinin (Dihydrocitrinone DHC) which is carcinogenic and neurotoxic.
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