Wondering if anyone has uploaded their raw DNA data to SelfDecode or Prometheus for more personalized information on how to supplement for their specific gene mutations?
Self Decode is a more expensive and user friendly system - which gives you semi personalized reports based on your gene variants.
Promethease is a little more DIY and is more of a literature retrieval system that that shows you all the literature that has been done on your DNA variant.
Some of the recommendations Self Decode has given me I have started to employ for my father however these supplements were not on my radar before i read his reports.
Just wondering if anyone familiar with these services had any informed opinions / 2 cents to share,,,
Warmly, Simona
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simonasays
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I have found that gene snp that have defects fairly accurately reflect health issues he has.
We had to go through naturopath who was authorised to order report so not cheap. But useful. I still refer to it. I would really love as many people as possible to get report so we can compare defects and symptoms. That way it may be easier to identify things that might help some people and not others.
Same! I also did my report and we have very similar genetic variants and it also puts me at an increased risk for PD. When i get a chance i will post them on here. Will be implementing a lot of the same things. I will look into opus. Thank you.
I did promthease years ago. Interesting report. It showed multiple variants in the snca pathway, but not the ones that people talk about. I think the company was bought by some bigger company recently.
These services, such as "Found my Fitness" typically rely on the data bases from Ancestry.com or 23andme. (Datapunk Opus23 uses a wide variety of data. Practitioners are certified with only 1 day of training!). Therefore, I would be EXTREMELY DUBIOUS of their validity for medical "diagnosis". I am not a cell biologist per se, or a geneticist, but I am a biochemist with a strong background in cell biology.
if you understand their protocols you will understand my concerns. All these services will vary in their gene mutation results, depending on their sample populations and their size, and who designed their computer algorithms, which should give you concern about someone diagnosing your "conditions" or "gene mutation(s)" from any of them.
Just use a little common sense before believing their results. If you are hyper about the possibility of a mutation, use the Mayo Clinic's Department of Clinical Genomics for their "genome sequencing" of your DNA. If you do, you will need an MD referral.
Or run Opus23's Rheingold app for the fun of it if you are on multiple drugs...I used amantadine, selegiline and sinemet (or stalevo or rytary)...it gave me...either CYP2E1 or CYP2C9, but both CYP2C9 and CYP2E1 for sinemet. why for only sinemet?
It told me:
"The CYP2 subfamily is responsible for the majority of P450-mediated drug metabolism in humans. While CYP2E1 itself carries out a relatively low number of these reactions (~4% of known P450-mediated drug oxidations), it and related enzymes CYP1A2 and CYP3A4 are responsible for the breakdown of a large number of toxic environmental chemicals and carcinogens that enter the body, in addition to basic metabolic reactions such as fatty acid oxidations.CYP2E1 metabolizes mostly small, polar molecules, including toxic laboratory chemicals such as dimethylformamide, aniline, and halogenated hydrocarbons . ..
While these oxidations are often of benefit to the body, certain carcinogens and toxins are bioactivated by CYP2E1, implicating the enzyme in the onset of hepatotoxicity caused by certain classes of drugs."
Thank you for that and always quite helpful to hear the thoughts on someone more qualified than me to figure it out. I am not familiar with the two sevices you mentioned however Prometheus seems to just scour pubmed for studies and then gives it a numerical rating based on quality of evidence. Selfdecode seems ti have ageneral report on specific traits (cognition ,mood, etc) and outlines which SNPs haave an effect on that characteristic. I thought it would be a good place to figure out which supplements / lifestyle choices are best to try rather than just taking the supplements that are commonly brought up here. Im not looking for any specific genes more like which pathways operate differently in a genetic variant and what someone can do to make up for that loss. Plan on posting a screen shot of selfdecode shortly
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