I am not seeking false hope nor do I want to perpetuate it but I do think there will be more treatments within the next 10-15 years.
A off the top of my head list:
There may be stem cells for PWP. Perhaps intravenous like the UT trial.
There may be personalized cell therapy (pluripotent neurons implanted in the brain) like Blue Rock (subsidiary of Bayer) is pursuing or Mass General or Kyoto.
Cure Parkinson’s will hopefully have found at least one successful repurposed drug that helps slow our decline. Exanatide or Ambroxol might be helpful.
Fecal transplants are looking like a possible source of some help.
Improvements in DBS are being trialed at UCSF.
I hope for gene therapy but I think that is likely more like 20 + years out.
Meds to reduce dyskinesia are being trialed according to MJFF. If dyskinesia can be mitigated that would be a big improvement.
A better understanding of the gut biome will hopefully lead to improved dietary recommendations.
What are your thoughts?
What is it realistic to hope for in the next 10-15 years?
I’m sure I’m not alone in my desire for some hope founded on substance and some improvements to look forward to. Did I miss anything?
Certainly, look for new therapies, but I think a more likely route forward is through the optimization of existing treatments. For instance, I suspect that many PwP are under medicated, for whom an extra 100 mg/day, say, of levodopa would give an improved QOL.
I actually think the Emma watch may have been electrical (rather than mechanical) and have a hunch that the tweaking required was so individualised that it was more akin to DBS than a mass marketable device we could each individually configure, and this is why the designer decided not to pursue it.
The gyrogear glove is probably closer, though they havent updated for some time.
Funnily enough I asked the very same question 5 years ago and I presume got the same stem celly responses that the guy who’d probably asked in 2010. More Levadopa anybody? 😂
It's a fair cop. Sort of. I think clinically available stem cell therapy, probably grafts involving brain surgery will be 10 years from first human trials.The difference is human trials have begun in Japan and Australia and, although ethically controversial, one US citizen. And that wasn't the case 10 years ago
A trial told me 5-7 so I round up to 10. I was told that there is a trial happening in California(actually happening) but I have not found anything online.
My current favourite is a drug from Annovis Bio called Posiphen (ANVS401). It is a small molecule that targets the mRNA of the SNCA gene, and stops it being used to create alpha synuclein proteins. Having shown that it seems to work (oral delivery at 80mg/day), they are now conducting a study with 40 PwPs to determine the optimum dose (5, 10, 20, 40 mg/day). They say that in a few months they hope to be ready to meet with the FDA to seek approval for a big Phase 2/3 trial.
While we can be hopeful about a "rescue" of sorts from an outside source, I put my money on the efforts that I can control: diet, consistent hard exercise, eliminating negative stress, focusing on what's right in my world.
I do all of that too. But I just turned 46 so in 10 years I will still be 16 years younger than you are. If I was in my 70s I would not care so much about a “rescue” as you called it.
I gene therapy looks promising for motor function. OXB-102 is being trialled now and I believe they have seen promising early results and are looking at escalating dose.
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What I learned only now after ten years.
Lets talk about levadopa. While it is reputed to be the most valuable medication in PD it can cause dyskinesia which alarms me.
I have Parkinson’s and my mother also had it?? 
