What improvements can we anticipate withi... - Cure Parkinson's

Cure Parkinson's

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What improvements can we anticipate within 10-15 years?

cclemonade profile image

I am not seeking false hope nor do I want to perpetuate it but I do think there will be more treatments within the next 10-15 years.

A off the top of my head list:

There may be stem cells for PWP. Perhaps intravenous like the UT trial.

There may be personalized cell therapy (pluripotent neurons implanted in the brain) like Blue Rock (subsidiary of Bayer) is pursuing or Mass General or Kyoto.

Cure Parkinson’s will hopefully have found at least one successful repurposed drug that helps slow our decline. Exanatide or Ambroxol might be helpful.

Fecal transplants are looking like a possible source of some help.

Improvements in DBS are being trialed at UCSF.

I hope for gene therapy but I think that is likely more like 20 + years out.

Meds to reduce dyskinesia are being trialed according to MJFF. If dyskinesia can be mitigated that would be a big improvement.

A better understanding of the gut biome will hopefully lead to improved dietary recommendations.

What are your thoughts?

What is it realistic to hope for in the next 10-15 years?

I’m sure I’m not alone in my desire for some hope founded on substance and some improvements to look forward to. Did I miss anything?

Thank you FWP (friends with Parkinson’s)

37 Replies

I think your summary is quite accurate. I think continuing improvements in focused ultrasound is another reason for optimism.

Certainly, look for new therapies, but I think a more likely route forward is through the optimization of existing treatments. For instance, I suspect that many PwP are under medicated, for whom an extra 100 mg/day, say, of levodopa would give an improved QOL.

10 yearsEffective stem cells (maybe just)

Widely available PTT mrg fus


Refined photobiomodulation

At least one of the mechanical devices (eg Emma watch)

A drug which makes a difference (mcc950, Zhittya Genesis angiogenesis, Denali /biogen)

And more

kevowpd profile image
kevowpd in reply to WinnieThePoo

I actually think the Emma watch may have been electrical (rather than mechanical) and have a hunch that the tweaking required was so individualised that it was more akin to DBS than a mass marketable device we could each individually configure, and this is why the designer decided not to pursue it.

The gyrogear glove is probably closer, though they havent updated for some time.

WinnieThePoo profile image
WinnieThePoo in reply to kevowpd

I was thinking also of stanford's vibrotactile research

Derwahli? Is that an Indian company? :-)

Thanks. This predictive text is on fire this morning

kevowpd profile image
kevowpd in reply to jeffreyn

Re-badged and patented mucuna! That ought to go over nicely.

cclemonade profile image
cclemonade in reply to kevowpd

Sarcasm and negativity helps no one.

kevowpd profile image
kevowpd in reply to cclemonade

Humour helps many, as it happens. Lighten up a bit, it won't hurt.

cclemonade profile image
cclemonade in reply to kevowpd

Oh…you were being “funny.” Ha ha

kevowpd profile image
kevowpd in reply to cclemonade

Rest assured you were never expected to find it amusing.

GioCas profile image
GioCas in reply to kevowpd

pranksters and detractors have no good intentions.

cclemonade profile image
cclemonade in reply to GioCas

Detractor is the perfect adjective for this 👍🏻

kevowpd profile image
kevowpd in reply to cclemonade

'Detractor' is a noun, FYI.

cclemonade profile image
cclemonade in reply to kevowpd

Bravo, you contributed a valid point.

Roche-Prothena trial of their drug PRX002

Funnily enough I asked the very same question 5 years ago and I presume got the same stem celly responses that the guy who’d probably asked in 2010. More Levadopa anybody? 😂

It's a fair cop. Sort of. I think clinically available stem cell therapy, probably grafts involving brain surgery will be 10 years from first human trials.The difference is human trials have begun in Japan and Australia and, although ethically controversial, one US citizen. And that wasn't the case 10 years ago

But 15 years is more likely

A trial told me 5-7 so I round up to 10. I was told that there is a trial happening in California(actually happening) but I have not found anything online.

My current favourite is a drug from Annovis Bio called Posiphen (ANVS401). It is a small molecule that targets the mRNA of the SNCA gene, and stops it being used to create alpha synuclein proteins. Having shown that it seems to work (oral delivery at 80mg/day), they are now conducting a study with 40 PwPs to determine the optimum dose (5, 10, 20, 40 mg/day). They say that in a few months they hope to be ready to meet with the FDA to seek approval for a big Phase 2/3 trial.


cclemonade profile image
cclemonade in reply to jeffreyn

I had not heard of that one. Thank you.

The diabetic-style pump for delivering c/l currently in CT from two, maybe three different drug companies.

Enjoy today.

Of course.

This Is NOT false hope but great news! and Thanks for posting this...I think there will be real advancements coming our way..

>What improvements can we anticipate within 10-15 years?

More effective ways to deliver levodopa...

kevowpd profile image
kevowpd in reply to Levod

Mucuna suppository?

Despe profile image
Despe in reply to kevowpd

I will buy it in a heart beat. You should try it, too, you never know, it might help your sarcasm.

GymBag profile image
GymBag in reply to kevowpd

Actually, I thought that was very funny

cclemonade profile image
cclemonade in reply to Levod

Which will help reduce dyskinesia.

Levod profile image
Levod in reply to cclemonade

yes, and staying "on" more consistently/reliably...

While we can be hopeful about a "rescue" of sorts from an outside source, I put my money on the efforts that I can control: diet, consistent hard exercise, eliminating negative stress, focusing on what's right in my world.

cclemonade profile image
cclemonade in reply to SonarsMom

I do all of that too. But I just turned 46 so in 10 years I will still be 16 years younger than you are. If I was in my 70s I would not care so much about a “rescue” as you called it.

SonarsMom profile image
SonarsMom in reply to cclemonade

I totally understand where you're coming from. Hopefully one of these breakthroughs will occur soon.

Farooqji profile image
Farooqji in reply to SonarsMom

I agree with you and always expect a miracle from God

God has so many calls upon his time. Perhaps He needs a little help from us. Who said “God helps those who help themselves”?

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