Interventional Influence of the Intestinal Microbiome Through Dietary Intervention and Bowel Cleansing Might Improve Motor Symptoms in PD

[Bolt_Upright]

Tobias Hegelmaier,1,† Marco Lebbing,2,† Alexander Duscha,1 Laura Tomaske,1 Lars Tönges,1 Jacob Bak Holm,3 Henrik Bjørn Nielsen,3 Sören G. Gatermann,4 Horst Przuntek,2 and Aiden Haghikia1,*

ion_ion's thread from 8 months ago got me thinking: healthunlocked.com/cure-par....

In 3 posts in this thread, one person's symptoms went away temporarily from a colonoscopy, one symptoms improved from a colon cleanse, and one symptoms improved from diarrhea.

This PD clinic does colon irrigation: theparkinsonsplan.com/detox...

BUT MORE IMPORTANT is this from 2020: Interventional Influence of the Intestinal Microbiome Through Dietary Intervention and Bowel Cleansing Might Improve Motor Symptoms in Parkinson’s Disease ncbi.nlm.nih.gov/pmc/articl...

"The impact of the gut microbiome is being increasingly appreciated in health and in various chronic diseases, among them neurodegenerative disorders such as Parkinson’s disease (PD). In the pathogenesis of PD, the role of the gut has been previously established. In conjunction with a better understanding of the intestinal microbiome, a link to the misfolding and spread of alpha-synuclein via inflammatory processes within the gut is discussed. In a case-control study, we assessed the gut microbiome of 54 PD patients and 32 healthy controls (HC). Additionally, we tested in this proof-of-concept study whether dietary intervention alone or additional physical colon cleaning may lead to changes of the gut microbiome in PD. 16 PD patients underwent a well-controlled balanced, ovo-lacto vegetarian diet intervention including short fatty acids for 14 days. 10 of those patients received additional treatment with daily fecal enema over 8 days. Stool samples were collected before and after 14 days of intervention. In comparison to HC, we could confirm previously reported PD associated microbiome changes. The UDPRS III significantly improved and the levodopa-equivalent daily dose decreased after vegetarian diet and fecal enema in a one-year follow-up. Additionally, we observed a significant association between the gut microbiome diversity and the UPDRS III and the abundance of Ruminococcaceae. Additionally, the abundance of Clostridiaceae was significantly reduced after enema. Dietary intervention and bowel cleansing may provide an additional non-pharmacologic therapeutic option for PD patients. "

THIS PAPER IS SO COOL. THEY LIST ALL THE FOODS THE PARTICIPANTS WERE FED.

"In summary, there is growing evidence that changes in the gut microbiome and metabolome may have a direct or indirect impact of the healthy and diseased brain, as is the case for PD. Interventions that may skew the gut microbiome composition and may have a therapeutic effect on the course of the disease. Although small in size, our proof-of-concept study suggests that bowel cleansing, a well-established treatment and good tolerable intervention, in combination with a dietary intervention including SCFA have a positive effective not only on the gut microbiome but may also have a beneficial effect on the clinical course in PD. Nevertheless, as mentioned above the potential side effects including orthostatic dysregulation, electrolyte imbalance, exsiccosis, infections, abdominal pain, diarrhea, nausea and vomiting must be considered."

So what they did here was have a control group, a group that ate vegetarian, and a group that ate vegetarian and got herbal enemas every day. The diversity of their microbiomes improved, some bad bacteria reduced, and their UPDRS scores got better. The enema group did better than the just diet group. Enema group improved UPDRS by 3.

This is exactly what I've been trying to accomplish by following the Specific Carbohydrate Diet (normalize the microbiome). I forgot to add the enemas!

Somebody might be taking a trip to Walgreens tomorrow

[Bolt_Upright]

Ingredients during the two-week diet which all patients with Parkinson’s disease (PD) have received:

Ghee Ghee is a pure clarified fat exclusively obtained from milk, cream or butter. Almost a total removal of water and non-fat solids with a total fat content of 62% is achieved.

Vegetables Onions, garlic, potatoes, carrots, chives, spinach, lentils, tomatoes, auberges, ginger, zucchini, rucola, cauliflower, fennel, broccoli, celery, leek, chicory, swiss chard, Chinese cabbage, kohlrabi, Muscat pumpkin, beetroot, chickpeas, mung beans, Lollo rosso, spring onions, cucumber, iceberg lecture, paprika.

Fruits Lemon, raspberry, strawberry, raisin, apple, radish, mango, figs, coconut, physialis, pineapple, peach, plums, oranges, grapes, cantaloupe melon, pomegranate, kiwi, banana, grapefruit, avocado, olives.

Cereals Spelt, wheat, rice (basmati), rye, oats, millet, barley, semolina, maize.

Milk and egg products Whole milk, eggs, quark, cream cheese, yogurt, sour cream, rice pudding, low-fat curd cheese.

Other Noodle (spaghetti, penne), amaranth, bulgur, quinoa, ascorbic acid.

Spices and herbs Vanilla, sugar, salt, pepper, coriander, cinnamon, chili, cardamom, cane sugar, basil, mint leaves, oregano, mustard, rosemary, marjoram, parsley, curry leaves, thymus, saffron, bay leaves, tridosha curry, lovage, star anise, ajwain, chervil, lime leaves.

Nuts, seeds and kernels Sesame, almonds, pumpkin seed, cashew, kernel, fennel seed, nutmeg, sunflower seeds, hazelnuts.

Oil and vinegar Olive oil, pumpkin seed oil, balsamic vinegar, walnut oil, sesame oil.

Other Rose water, honey, maple syrup, soy sauce.

[Godiv in reply to Bolt_Upright]

Interesting! Thank you. I think I’d like the diet more than the cleanse.

[park_bear]

Improved UPDRS by only 3 points is of minimal clinical significance.

[Bolt_Upright in reply to park_bear]

Somebody pointed this important point out to me: "the levodopa-equivalent daily dose decreased after vegetarian diet and fecal enema in a one-year follow-up". That's kind of interesting.

[Bolt_Upright]

I'm more thinking Miralax more than enemas.