After reading park_bear's very interesting post regarding Permethrin as a potential cause of PD, it got me to thinking! Here is a link to his post :
Here is a link to the FMT post that showed significant improvement in PwP in just 12 weeks:
Since the post about Fecal Microbiome Transplant (FMT) just went up also, it has renewed my interest in the gut microbiome and with park_bear's post and the FMT post both fresh in my mind, the recurring question came to mind,
"What if the common denominator in Parkinson's Disease really is a negatively altered gut microbiota?"
With that thought in mind, I searched for any studies that might show if Permethrin might have any ability at all to alter the gut microbiome toward more pathogenic bacteria. I realized this was an unlikely long shot, but I had to look. As expected, there were only a couple of rat studies. So I will get right to the point.
Interestingly, one of the studies came to this conclusion :
>>> ' In summary, exposure to PERMETHRIN could affect the fecal microbiota and could be a critical factor in contributing to diseases. ' <<<
In the other study the rats got Permethrin or they got Permethrin plus a substance called "Electrolyzed Reduced Water" (ERW) which has antioxidant qualities. Permethrin resulted in increased gut permeability, increased inflammatory mediators, hepatic inflammation, increased pathogenic bacteria and negatively altered microbiota. The Permethrin + ERW group faired better and had more beneficial bacteria that produced more butyrate and less pathogenic bacteria.
This to me suggests that fixing the gut microbiota through FMT or other methods which has been discussed in the mannitol post at length, is a needed starting point and based on the FMT study results can potentially ameliorate the Permethrin damage to the gut microbiota. Here is a link to the Mannitol post that discusses different ways of altering the gut biome including FMT.
This article about pesticides and how they can affect the gut microbiota was also interesting :
Lastly, it appears that the gut microbiota definitely plays a very major role in PD and manipulating the gut microbiota toward less pathogenic bacteria and more healthy bacteria resulting in reduction of motor and non motor symptoms, elimination of Small Intestinal Bacterial Overgrowth (SIBO), which apparently is common in PwP as well as elimination of constipation. It's just an opinion, but it may be worthwhile concentrating our efforts on repairing the broken gut microbiota through whatever means we can find that are not dangerous or wait until FMT is available to the masses.
On a related note regarding wriga's broccoli seed protocol experiment in progress, it is worth noting that broccoli has positive effects on the gut microbiota as does melatonin! Mannitol, while not noted for making major changes in the gut microbiota, does offer benefit via increased butyrate production when there are still enough of the butyrate producing bacteria left in the PD gut for the mannitol to interact with and butyrate is known to have gut reparative effects. Berberine interacts with the gut biome to produce more levodopa which then goes to the brain to be converted to dopamine. Cinnamon also has positive effects on the gut microbiota. I could go on, but I think you have the general idea. It's amazing how so many of the beneficial things discussed on this forum have positive effects on the gut microbiota or is it just coincidence??? The alternative seems to be just continue treating symptoms as they continue to increase while doing little to nothing to try and repair one important underlying problem.