Could a prostate drug slow or stop Parkinson’s?

[Farooqji]

Further evidence emerges to suggest that terazosin — a drug currently used to treat enlarged prostate — may have the potential to slow or stop Parkinson’s. We take a look at the story so far and the next steps.

medium.com/parkinsons-uk/co...

[Hidden]

Thank you for posting studies like this. Much appreciated.

[Patrickk in reply to Hidden]

[my usual cut-and-paste ... just spreading the apparently very good word]

Bydureon (a.k.a., Exenatide), a repurposed Type 2 Diabetes drug is now in third-stage trials in UK for stopping Parkinson’s in its tracks — results expected 2023. Testing — mice, open label, double blind — has been going on for 10 years and it has been positive every time.

scienceofparkinsons.com/201...

According to a very sensitive test, Homeostasis Model Assessment for Insulin Resistance (HOMA-IR), 2/3 of Parkinson’s patients are supposed to be insulin resistant. IR may be treated with Bydureon (Exanatide). Just an angle that might get us one step closer to getting Bydureon.

cureparkinsons.org.uk/news/...

[Hidden in reply to Patrickk]

I’m cautiously optimistic. It sure is a spirit lifter. Thank you for reminding me of this study. The cough medicine study, prostate medicine, and the diabetes medicine study all make me cautiously hopeful. I have found two people taking the cough medicine.

One man taking the prostate medicine.

I wish more on this forum would report back.

[JerryinSATX]

I just started taking Terazosin for prostate issues a few months ago and have seen a decrease in my off-time. I am taking 2mg daily and might ask my PCP to increase the dosage to 4mg. Will report any changes in a few months.

[Hidden in reply to JerryinSATX]

I’m sorry to learn of your prostrate issues but elated to learn Terazosin is decreasing your off-time. I hope your PCP will up your dose.

[Bolt_Upright in reply to JerryinSATX]

May I ask how the Terazosin is working for your PD symptoms?

[Despe]

Terazosin has been discussed previously. Yes, it sounded very promising so my husband started it for his frequent urination problem. It did help, however, he experienced severe swelling of his ankles. Checked with his cardiologist who said "No, it's not heart related." Nevertheless he stopped it, and that is unfortunate, as it seemed that it really helped his urination frequency problem.

[JerryinSATX]

My PD symptoms have not gotten much better, but have not gotten any worse. I plan to start High Dose Thiamin soon.