My husband was diagnosed 2 years ago; the main symptom is tremor in one hand. He was prescribed Sinemet but still has never taken it, because the side effects warned about on the paper in the prescription box sound so much worse than his current situation, it sounds not worth it. Meanwhile, tremor has gotten worse. I know everyone is different but: does Sinemet tend to stop tremor?
Another reason he hasn’t wanted to start taking it is that the PD nurse said it might not work for tremor, and tremor is the hardest thing to control in PD. Also, knowing that once he starts taking Sinemet, it seems the body begins to build up resistance and would only have to take more.
He takes Magnesium, B1, mucuna and mannitol; these seem to help him feel better in mood and energy but no help for tremor. So back to the original question: does Sinemet tend to stop tremor?
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Kindhuman
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Thank you for the suggestion of taking B1. I just checked the B1 tablets and they are only 100 mg per tablet. Can you/anyone recommend a higher dose B1 tablet? Thanks!
The positives after B1: no bradykinesia, I cut my food with a knife, no button difficulties, brush my teeth now w/o needing elect brush, more strength. Getting in and out of bed, turning over is easier. No more constipation. Parkinson's progression stopped. Suppressed most motor and non-motor symptoms...
Entering my 9th year post diagnosis and have not fallen, not once, to the surprise of my neuro.
I follow this regimen:
My neurologist. She prescribed one tablet every three hours (25/100 IR), and one 50/200 CR at bedtime.
Just completed the first night (12/30/2020) with this protocol. Can say the doctor was right. Smaller doses more frequent. Keep the dopamine at even, consistent level without extreme highs. Best nights rest in a long time. Lot less tremor. In my eight years since diagnosis, no dyskinesia, no falls. Current (Nov. 2020) Push Pull Test only one step recovery. See video of this test under Announcements. Click See All. FaceBook group, Parkinson's thiamine hcl
2 x day (6 a.m. 2g, and at fourth hour 2g) vitamin B1 (as thiamine HCL) 500mg easy swallow capsules.
Magnesium L-Threonate 144mg per week.
Doxazosin causes constipation. Not recommended.
Pramipexole 0.05mg, once nightly. Caused edema. Not recommended.
B1 Thiamine therapy reference / stop progression, suppress motor and non-motor symptoms:
(Thiamine HCL is oral substitute to injecting B1) 2 x day (morning 2g and at lunch 2g)
Doctor Costantini strategy that I find helpful "thiamine hcl stops the progression forever...".
Parky people say the first five years is your honeymoon stage with Parkinson's. After that, progression more rapid.
I have gone from slow motion to normal motor action since joining the growing number of PwP that have started B1 regimen/protocol. –
Doctor Costantini - “Why is this? Because there is no medicine or drug that is able to affect all of the organs, whereas all of the organs function thanks to Thiamine. An important detail”, adds doctor Costantini, “the Thiamine therapy brings no collateral damage with time”.
And did Dr. Constantini (God bless him) say that the B1 protocol works only with taking a PD drug like Sinemet or will it work for some without taking the PD drug?
Hi Roy, have been following your discussions on various topics for some time and am particularly interested in the thiamine and took the dosage you suggested, 2g at breakfast, 2g at lunch. I certainly noticed a considerable increase in energy, but the bradykinesia was full on for the whole day. Was your experience similar or did you notice an improvement instantly? I would love to hear any thoughts. I was diagnosed in 2013.
FIRST STEP: a UPDRS test, a push test with video, a walking and turning test with video, a talking test with video and possibly a writing test with video, standing from seated on hard back chair video with your arms crossed. These videos are kept on file to be used for comparison with future videos. This is a fairly accurate means of documenting improvements over time as it is actually fairly easy for some people to not realize how much they have improved over time.
No one knows whether or not Sinemet will be beneficial or cause side effects, including his doctor. The list of side effects included on the manufacturer's insert for every pharmaceutical will scare the be Jesus out of anyone. Personally, I would not go by that. If I were in his situation, I would take the drug and see how it made me feel.
Hello Kindhuman ~ my husband is newly diagnosed. His main symptoms are left leg tremor (very obvious) & anxiety. Our ND started him on ½ 3x a day for 2 weeks, then increased to one 3x a day. He didn’t seem to get any relief till he increased to the one pill. He missed one dose a couple days ago & he could really tell the difference in both symptoms. We are not prescription pill people. He just turned 70 and sinemet is the only prescription he’s on.
Not necessarily, I have similar symptoms-tremor mostly in right hand. I take Sinemet 1x3/day and it has helped me with Brady Kenesia which effects my swim speed. I have tried many different meds and none has helped my tremor. As per my Dr. my tremor is not affected by meds. Haven't had any need to try DBS yet. I manage it by different kinds of exercise--swim, hike, stationary bike, Qi Gong, PD Warrior, PD dance. I exercise 1-2 hrs 7 days/week.
I have tremor dominant pd. I’ve been diagnosed for a little over a year. I take sinemet and it almost stops my tremor and improves my quality of life. I take the smallest dose possible. Also take magnesium and B1. Wishing you both the best.
I have been taking Sinemet for two years now...it definitely helps the tremors. If I am late taking it - I know it - plus I get edgy and short with my husband. I have to take it with some kind of food or I get sick to my stomach(not a pretty sight). I walk at least 3 -3.5 miles 6-7 days a week, lift weights -twice a week, golf and play pickle ball, The busier I am the less I notice the tremors. I HATE sitting around!
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Kudos!
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