OK, it's a Mouse Study, But It's Encouraging...

[jimcaster]

It turns out that chronic ISR activation and resulting blockage of cellular protein production may play a role in a surprisingly wide array of neurological conditions. Below is a partial list of these conditions, based on a recent review by Walter and colleague Mauro Costa-Mattioli of Baylor College of Medicine, which could potentially be treated with an ISR-resetting agent like ISRIB:

Frontotemporal Dementia

Alzheimer’s Disease

Amyotrophic Lateral Sclerosis (ALS)

Age-related Cognitive Decline

Multiple Sclerosis

Traumatic Brain Injury

Parkinson’s Disease

Down Syndrome

Vanishing White Matter Disorder

Prion Disease

neurosciencenews.com/age-co...

[WinnieThePoo]

"researchers showed rapid restoration of youthful cognitive abilities in aged mice,"

I have visions of these mice suddenly able to do the Times crossword again

Intriguing

[BootsOn in reply to WinnieThePoo]

🤣

[JAS9]

This small molecule was discovered in 2013 by Walter so it's been around a few years. Evidently the brain hacker community is interested in it, so there may be some first-hand accounts from people that actually used it. Conversation on Reddit discusses how it might be used to restore a brain damaged by concussion.Two things I've learned so far: it works differently than many other medicines in that it's supposed to unstick something in the brain that gets stuck in a survival mode rather than a repair mode. In other words, this would be something you would take for a short time just to unstick your brain so that it can get out of survival mode and perform normally again. Which is good, because I also discovered this stuff is very very expensive if you can get it at all. Which of course I would not recommend until we can get it as a prescription from our doctors.

One other tidbit I discovered is that the very well-funded and talented company called Calico, which is owned by Alphabet (which also owns Google) recently purchased a license to study this molecule. Hopefully their well funded researchers will find whatever there is to find and market it.

[PalmSprings]

Oh man, sounds good.