OK, it's a Mouse Study, But It's Encourag... - Cure Parkinson's

Cure Parkinson's

26,302 members27,662 posts

OK, it's a Mouse Study, But It's Encouraging...

jimcaster profile image
4 Replies

It turns out that chronic ISR activation and resulting blockage of cellular protein production may play a role in a surprisingly wide array of neurological conditions. Below is a partial list of these conditions, based on a recent review by Walter and colleague Mauro Costa-Mattioli of Baylor College of Medicine, which could potentially be treated with an ISR-resetting agent like ISRIB:

Frontotemporal Dementia

Alzheimer’s Disease

Amyotrophic Lateral Sclerosis (ALS)

Age-related Cognitive Decline

Multiple Sclerosis

Traumatic Brain Injury

Parkinson’s Disease

Down Syndrome

Vanishing White Matter Disorder

Prion Disease

neurosciencenews.com/age-co...

Written by
jimcaster profile image
jimcaster
To view profiles and participate in discussions please or .
Read more about...
4 Replies
WinnieThePoo profile image
WinnieThePoo

"researchers showed rapid restoration of youthful cognitive abilities in aged mice,"

I have visions of these mice suddenly able to do the Times crossword again

Intriguing

BootsOn profile image
BootsOn in reply to WinnieThePoo

🤣

JAS9 profile image
JAS9

This small molecule was discovered in 2013 by Walter so it's been around a few years. Evidently the brain hacker community is interested in it, so there may be some first-hand accounts from people that actually used it. Conversation on Reddit discusses how it might be used to restore a brain damaged by concussion.Two things I've learned so far: it works differently than many other medicines in that it's supposed to unstick something in the brain that gets stuck in a survival mode rather than a repair mode. In other words, this would be something you would take for a short time just to unstick your brain so that it can get out of survival mode and perform normally again. Which is good, because I also discovered this stuff is very very expensive if you can get it at all. Which of course I would not recommend until we can get it as a prescription from our doctors.

One other tidbit I discovered is that the very well-funded and talented company called Calico, which is owned by Alphabet (which also owns Google) recently purchased a license to study this molecule. Hopefully their well funded researchers will find whatever there is to find and market it.

PalmSprings profile image
PalmSprings

Oh man, sounds good.

Not what you're looking for?

You may also like...

Colostrum: the most important nutrient for the prevention of chronic conditions

Autoimmune conditions are those in which the body starts producing antibodies against itself....

Vascular Dysfunction in the Brain as an Initiating Event in Parkinson’s Disease

https://parkinsonsnewstoday.com/forums/forums/reply/20641/ The concept that Parkinson’s disease is...

Anxiety Is A Common Problem In PD And The Following Study May Offer A Potential Remedy

The following article from Johns Hopkins explains that up to 40% of PwP have anxiety :...

Aluminium in human brain tissue from donors without neurodegenerative disease: A comparison with Alzheimer’s, multiple sclerosis and autism.

Aluminium in human brain tissue from donors without neurodegenerative disease: A comparison with...

Excess Iron in Brain Cells Worsens Parkinson’s Symptoms, Mouse Study Shows

Excess Iron in Brain Cells Worsens Parkinson’s Symptoms, Mouse Study Shows...