How does Apokyn help PD?

[kaypeeoh]

I see it's apomorphine. I've used apomorphine in my veterinary practice for nearly 40 years. It's my drug of choice for poisoning cases. I get it in 5mg tabs. For a dog who ate a large bag of Halloween chocolate kisses I'd press one tab under the upper eyelid. It gets into the blood stream as quickly as an IV. 5 minutes after the insertion he's vomiting and won't stop til the stomach is empty. Only problem if he's not watched closely he starts eating the vomited chocolate. Sorry, no photos. I don't see how this drug could help PD.

kpo

[LAJ12345]

Very nice imagery there! Thanks🤩

[sharoncrayn]

APO pumps.

We have had a couple of discussions about its use...pro and con.

Sharon

[ElliotGreen]

It's a dopamine agonist.

The fact that it makes people vomit made it harder to use, but they worked around that.

From the Wikipedia page:

en.wikipedia.org/wiki/Apomo...

The use of apomorphine to treat "the shakes" was first suggested by Weil in France in 1884,[48] although seemingly not pursued until 1951.[49] Its clinical use was first reported in 1970 by Cotzias et al.,[50] although its emetic properties and short half-life made oral use impractical. A later study found that combining the drug with the antiemetic domperidone improved results significantly.[51] The commercialization of apomorphine for Parkinson's disease followed its successful use in patients with refractory motor fluctuations using intermittent rescue injections and continuous infusions.[52]

[Despe]

Hello KPO!

Wish you were my dog's doctor!

[honeycombe3]

I wasn't going to mention this but my daughter-in-law is a vet and she said the same thing. It is used as an emetic for animals.

It is also a Dopamine Agonist and works well alongside other more conventional PD treatments.