In this episode they review all the studies of hydroxychloroquine.
A lot of excellent info.
Since I posted this, YouTube has removed the video. I cannot imagine why.
So, I have replaced it with a more recent one.
This is the best, most unbiased straightf... - Cure Parkinson's
This is the best, most unbiased straightforward daily briefing I have yet found -- from John Hopkins.
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MBAnderson
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Love the informative series.
On the recent VA retrospective study result -
"The group that had no hydroxychloroquine..actually was not as sick potentially as the group that got hydroxychloroquine"
The same was also pointed out on this forum earlier.
The only problem with a randomized placebo-controlled double-blinded trial right now is that we're dealing with a critical life/death situation, and we're out of time. It seem almost unethical to withhold potentially life saving drugs (or experiment dangerous drugs) based on a lottery when the outcome could be death for the hopefuls. So many are dying right now because of such clinical trials.
That 88% (median age 68) and 97.2% (age >65) mortality rates once you go to the ICU for ventilator is startling.
It really calls into question the usage of ventilators for coronavirus if the patient is capable of breathing voluntarily.
Wouldn't you know it, but pretty much all needing mechanical ventilation are already critically low on oxygen levels. Do everything you can proactively to avoid ending up at an ICU.
REALLY
I saw studies that showed NIV high flow oxygen was more effective than invasive ventilation, it washes out carbon dioxide to prevent buildup.
How many of these COVID-19 patients had emphysema and/or COPD (or ALS) where carbon dioxide buildup is a complication of their illness?
SE
This may be of an interest. Attention at 12:48 mark of V/Q Mismatch, Shunt, and Diffusion Abnormality on mechanisms of hypoxemia with Covid-19. Explains why ozygenation/ventilation don't always work, especially with congestive heart failure.
youtube.com/watch?v=nO4xgcI...
Thank you for this. I have a vitual visit with Dr. Bach next week and will discuss this with him. In light of COVID-19, I need a protocol for my care should I become ill. 💕
SE
I know you’re a good researcher so I leave you to it but don’t forget that melatonin is a hormone, so a major precaution is required. Be sure to be very thorough with its overdose and possible side effects and apply it for an emergency only, especially at megadose.
You might be interested in this article.
naturopathiccurrents.com/ne...
I was already aware of the potential of melatonin to treat my ALS and benefit other neurodegenerative disorders.
The products are expensive at $200 USD for 30 days of 400mg melatonin suppositories. My functional medicine doc recommended glutathione suppositories.
I asked Google if I could combine glutathione and melatonin and learned that melatonin increases glutathione levels and there is indeed a commercial product that combines the 2 in a suppository.
pubmed.ncbi.nlm.nih.gov/168...
Then I wondered, what else can I put in this suppoitory? Probiotics, amino acids and many other nutraceuticals. I'm excited about the potential of this therapy now that I know the process of my neurological injury. This has been a long haul and I'm grateful that my decline has been slow enough to give me the opportunity to learn and heal. 🙏🤞
Words cannot express my gratitude to the research warriors on this forum. 💕
I certainly hope that it could help your condition. Some people can experience considerably more adverse reactions than others with the overdose, including possible disruption in the pineal gland after years of overuse. Be sure to consult with your Dr at such an extreme high dosage.
I will discuss it first, don't want to do more harm.
Great. Check out this article before the discussion.
I take 80 mg melatonin daily. I do so because the longtime editor of the Pineal Journal, Russell Reiter, said he takes 200 mg a day,,,, controls the fire in the brain. I was diagnosed with PD six years ago, still not taking meds.
Hi bubbles77. Welcome to the forum. Are you saying that your PD progression stopped solely because of the megadose of melatonin? What are your symptoms?
Russel Reiter is a biologist who did most of the melatonin studies on laboratory rats and mice before he published his 1996 book on melatonin that claimed it even combats aging. However, even he recommends certain groups of people shouldn't risk taking the hormone - children, pregnant women, nursing or trying to conceive, people with severe allergies, with mental illness, autoimmune diseases/MS/RA, leukemia, lymphoma, anyone taking steroid drugs, etc. He said "some diseases and conditions might be exacerbated by melatonin."
Practically all sleep experts are aware of the extreme mixed results and negative side effects experienced by people using melatonin. It doesn't help in at least half of the people who try it while some people don't metabolize it well and end up feeling drowsy and ill while worsening their insomnia. The majority of experts recommend staying under 1-3 miligrams. Because it is a hormone (and directly affects estrogen, prolactin, gonadotropin, etc.), you can't discount that the megadose of the powerful hormone that changes multiple physiological systems including cardiovascular, immune, metabolic, reproductive, etc., could be harmful/backfire in the long run even if short-term usage is relatively safe.
The supplement could be beneficial for people with compromised melatonin production with sleep wake disorders as in calcified pineal gland and sundowning with advanced neurological diseases, but precaution should still be taken to find an optimal effective dosage as to jumping to an unknown territory.
Unlike the few on this forum who constantly/recklessly share only the select positive researches and potential benefits of megadose melatonin disregarding the adverse side effects (especially long-term), here's a relevant quote to take into account.
"...some beneficial effects in animal studies were not seen when they used super high artificial doses of melatonin that your body can't produce. They were seen when a more "normal" range was used though. The scientists speculated that it had to be levels that the body could recognize so to speak. ...Reiter suggests a dose range from 0.1mg to 10mg depending on the aim or condition. I forgot the exact figure, but there's an individual difference response to melatonin of about 75%. Those who are very sensitive, will have anxiety and nightmares from taking just even 1 or 2 mg, which is why some suggest to start with 0.5mg or less...Melatonin had the greatest effect in a very particular range - a range that happens to be the amount of melatonin present in the human body. Concentrations above and below that amount had no effect on the cells."
bubbles,
Thank you for posting your information!
That is very interesting as that is the adult dose (80) mg/day) that Dr. Neel is using in his patients for Covid-19 to good effect!
Dr. Reiter is the one who complimented Dr. Neel for taking the known science of Melatonin and actually applying it to his Covid-19 patients! He said that was the right move! I'm a big fan of melatonin, but his 200 mg/day that he takes himself is more that I had previously heard of in humans! I guess that is one way to test it! Bats average about 5 times the adult human level and that is one theory why they can carry SARS CoV-2, but apparently not be affected by it. Children in the 3~5 year range seem to peak around 125 pg/ml whereas an octogenarian might be around 5~10 pg/ml. I'd be very interested in seeing where an 80 mg dose of melatonin places an octogenarian"s melatonin level at.
How long have you been taking 80 mg of Melatonin a day and do you take it as a single dose or divided dose? There are studies that suggest that melatonin can be of use in PD. It does cross the blood brain barrier and it has two things that are needed in the PD brain, potent antioxidant activity and antiinflammatory activity, both of which are at elevated levels in PWP.
If you don't mind, I would like to copy your post into the Melatonin for Covid-19 post since your daily dose is also the treatment dose that Dr. Neel is using?
Here is a quote from Dr. Reiter on Dr. Neels work with melatonin :
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
One of those supporting the idea is Russell Reiter, PhD (Professor of Cell Biology at UT Health Center in San Antonio). Reiter’s thoughts were included in an online article last Wednesday.
Reiter is one of the world’s leading melatonin researchers and he is also the editor and chief of the Journal of Pineal Research and on the editorial board of 7 other journals.
Last Wednesday, April 8th, he stated, “I understand Dr. Neel has treated patients successfully with melatonin. This is certainly newsworthy. Likewise, his rationale for the use of melatonin as a potential treatment for COVID-19 is important. A published report supports his rationale, COVID-19: Melatonin as a potential adjuvant treatment”, stated Professor Russel J. Reiter, Ph.D in an interview. “Dr. Neel’s rationale for the use of melatonin as a potential treatment for COVID-19 is justified on the basis of the actions of this molecule”, said Reiter who was a part of this report that was published in February-March 2020 during the COVID-19 pandemic, co authored in conjunction with several medical professionals in China .
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Art
good point
Best post yet on the subject.
Because I'm this kind of geek. I told my husband that something doesn't add up - when reading research is your pastime (citizen scientist) you begin to recognize anomalies - there was something, a variable (pharmaceutical) that wasn't controlled for in research on these elderly male COVID-19 patients with sky high mortality rates. That something is heart medication.
Let's research the hell out of this.
SE
Another variable not controlled for is vitamin D status. Vitamin D deficiency is commonplace and does aggravate the impact of viral respiratory infection.
and Zinc!
They almost always discount the importance of these vitamins (A, D, C, B, etc) and minerals, and what's crazy is that studies are out there.
Just look at the below article example (and read the comments) -
"Thiamine deficiency can develop in patients secondary to inadequate nutrition, alcohol use, or any form of acute metabolic stress. Patients with sepsis are frequently thiamine deficient. Patients undergoing surgical procedures can also develop thiamine deficiency, giving rise to complications such as heart failure, delirium, neuropathy, gastrointestinal dysfunction and unexplained lactic acidosis….The outcome and clinical course of 47 consecutive sepsis patients treated with intravenous vitamin C, hydrocortisone, and thiamine during a seven-month period, were compared with 47 patients who received the present standard therapy. The hospital mortality in the treatment group was 8.5% (4 of 47) compared with 40.4% (19 of 47) in the standard treatment control group. Because this is published material, you would think that this treatment would be immediately taken up in every hospital emergency room. However, until the use of nutrients in the treatment of disease enters the collective psyche of the medical profession, it is unlikely that it will be generally accepted."
hormonesmatter.com/reconsid...
I think this is the episode he talks re zinc, C, & D
youtube.com/watch?v=NM2A2xN...
He is one of the few rare MDs who talk about it. The rest are oblivious.
Is there a link that states how much melatonin is correct to take for corona or have you read it somewhere? Thx Chris
All of the melatonin information is here:
healthunlocked.com/parkinso...
Dr. Neel is currently giving adult patients about 80 mg/day/in 4 equal doses. For severe symptoms and or larger people he has mentioned as high as 100 mg/day and smaller people and minor symptoms as low as 40~50 mg/day. Manila is using 36 to 72 mg/day in 4 divided doses also. Filipino people are generally smaller and they may be treating younger individuals.
Art
Marc,
The ventilator death rate is astounding! I would try and avoid that like the plague! Oh wait, this is sorta like the plague isn't it! I think I would try melatonin early on because so far Dr. Neel has none of his patients progress once starting on it! Doesn't seem like much of a downside with melatonin and all of his few patients have improved after a day! At the Doctors Hospital in Manila, they appear to have used it on patients that are in more serious condition with similar results to Dr. Neel. I wish they would publish their results soon.
Art
I wonder what it would be if you added PWP as a variable in addition to>65? 99.9%?
Well, it seems that any simultaneous illness tends to affect PD symptoms negatively, and sometimes the medications can add to the difficulty, at least temporarily. So I would think a more severe virus of this type would push the inflammatory burden higher and the oxidative stress levels higher which are both already elevated in PD. Seems like the outcome may be worse than for a non-PD patient.
On the other hand, melatonin reduces inflammation, ROS & RNS and modulates the immune system away from a cytokine storm and relieves symptoms quickly and Dr. Neel is thinking a bit ahead by suggesting using dissolving sublingual melatonin for patients already on a ventilator since pills and tablets are not an option in that situation.
Being an over the counter supplement, doctors can recommend it to their patients now and Dr. Neel's latest update sounds like doctors who are contacting him are thinking of trying it with their patients. One in Florida already has with rapid improvement in the patient. The very good safety profile makes it easier to decide on!
When your melatonin level is as low or nonexistent as it is in 65 year olds and older, you are clearly in the cross hairs of this virus!
Art
In addition to all the reasons you said, our immune system is compromised.
Melatonin rectal suppositories are an option too.
SilentEchoes,
Forgive me for the delay in responding, I was busy pulling my pants back up!!! 😉😉😉
I like that idea. I can't say as I have ever tried it, but it sounds very doable under the circumstances!
Thank you for that!
Art
ech!
That was just my poor attempt at suppository humor, Marc! The idea sounds great though!
Art
🤣🤣🤣🤣🤣
It's not as crazy as it seems.
This one:
advancedbiomecorp.com/produ...
And this one:
drvitaminsolutions.com/prod...
No, I am definitely a believer in these alternate delivery routes, nothing crazy about it! They even have retail melatonin creams that can work also or if they want higher strength they can have a compounding pharmacy compound a more potent cream to more easily reach the required level that Dr. Neel is finding effective in his patients.
In the case of a ventilated patient who is in critical condition, it may be appropriate to use a suppository, a sublingual pill and topical cream delivery in order to get the melatonin level up high as quickly as possible in such a critical patient.
I think about these important aspects to melatonin because I believe melatonin is the answer!
Art
I think you're right about melatonin, it's the master antioxidant. Zinc is important too.
I lost the ability to swallow pills so I am always devising ways to supplement. I use vitamin patches from Patch MD.
I like the combination of ingredients of the advanced biome corp but not the price - off to make suppositories. 😉
I found this recent study, neurological disorders are lumped together and far down the list. The more comorbidities the worse the outcome. Seems intuitive.
The whole series is very good! I just don't understand how he goes to work as a doctor and then still has time to do this series too! The other day his video discussed what he has to do once he gets to the hospital before he can even start to see his C-19 patients and then he described how he has to wear a surgical mask over an N-95 mask. The N-95 doesn't come off until the end of the day and he has to change the surgical mask after seeing a patient. At the end of the shift, he has to go to a plastic sheeted area where he has to remove his protective gear in a very specific order in order to prevent getting infected. The steps of removal are so critical that a person has to be there at the plastic sheeted room strictly for the purpose of making sure the medical staff does everything in the proper order. After that he goes to his car where he has to go through a complete routine in order to further protect himself and his family from getting infected. Then he drives home and removes all of his clothes in the garage and throws everything directly into the washer on the hottest setting. Then goes inside straight to the shower where he takes a perfectly timed shower that alternates between hot as he can take and cold as he can take in order to build up his immune system!
When he was done explaining the whole process, I felt exhausted! He has to be very dedicated to go through that everyday! I have put several of his videos in my C-19 post because his explanations are so clear and concise and easy to understand, to me, Dr. Seheult is an amazing person and I am more than impressed!
Art
Problems in nursing homes anf long term care is, and will always be, that their staff should do this to, but they do not have the same caliber staff and level of training.
I believe it is impossible to even have an accurate number of deaths in the U.S. The hospitals are struggling because elective surgeries have all but disappeared, and people are postponing going to the hospital for fear of catching Covid. Did you know US hospitals are paid $13,000 for every Covid patient they treat? Did you know the US hospitals receive $36,000 for every Covid death? Did you know doctors are asked to change the cause of death, whether it be from a heart attack or any other disease, to Covid? Why???
Why is something as simple as our having an oxygen mask not workable?
Good point. We have all been manipulated, including the doctors and nurses on the front lines. Fauci said there would be a pandemic during Trump's presidency. How did he know that?
Fauci was responsible for breaking the law of 1989 about not enhancing a virus, making it more virulent. He shared the corona virus with China in Wuhan. He says we cannot get back to normal until a vaccine is developed. He cheated renown scientist, Judy Mickovits and stole her research on AIDS. He needs to be prosecuted. He, along with Bill Gates, are dangerous.
Bill Gates gives millions of dollars to Johns Hopkins.
Why is that bad?
It’s not Marc. It’s a good thing.
He currently owns the largest vaccine company. His foundation......there are two. Look at all those impoverished nations who have had extremely bad results from his vaccines: India and parts of Africa. Horrifying. Vaccines don't have to be tested. The manufactures of vaccines cannot be sued.
I don't believe either of those things are true.
Research. He stated in a TedTalk, that is easily available, that vaccines were a way to control the population. Sounds unbelieveable, doesn't it.
For some reason I cannot understand, YouTube is removing some of these videos, so here's a recent one, just so we can stay one step ahead YouTube.
Here's a good one, 5 minutes and non-technical = for us layman = how to measure hypoxia.
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