Parkinson’s disease and iron

[Farooqji]

While the initial causes of Parkinson’s disease (PD) are not clearly defined, iron deposition has long been implicated in the pathogenesis of PD. The substantia nigra of PD patients, where the selective loss of dopaminergic neurons occurs, show a fairly selective and significant elevation in iron contents. However, the question remains whether iron deposition represents the initiation cause or merely the consequence of nigral degeneration. Here, we describe existing findings regarding the interaction of iron with neuromelanin and alpha synuclein, the iron deposition in experimental animal model of PD and sporadic and familial PD patients, and the treatment option involving the use of iron chelators for targeting the aberration of iron level in brain. This review may provide us a better understanding of the role of iron in PD to address the question of cause or consequence.

link.springer.com/article/1...

[pvw2]

From the abstract you still can't tell if the research separated iron explaining why microbleeds degrade the neurons versus iron degrading the neurons independent of microbleeds.

[Farooqji in reply to pvw2]

Here's a link to the full article

drive.google.com/file/d/15m...

[MBAnderson in reply to Farooqji]

My blood panel shows too much iron. What do you thinks the best way to reduce it? Donate blood?

[Farooqji in reply to MBAnderson]

If you are prone to iron overload, you can minimize the risk of health problems by:

1. Reducing your intake of iron-rich foods, such as red meat.

2. Donating blood regularly.

3. Avoiding taking vitamin C with foods that are rich in iron.

4. Avoid using iron cookware.

healthline.com/nutrition/wh...

[CaseyInsights in reply to MBAnderson]

You may also want to consider iron cheating/ inhibiting foods like wild blueberries, turmeric and flaxseed.

An entire list of foods found here -

thalassemiadiet.com/blog/na...

[MBAnderson in reply to CaseyInsights]

Thanks. I ingest each of these three these things.

Good article.