Relationship between brain iron deposition and mitochondrial dysfunction in idiopathic Parkinson’s disease March 2022 molmed.biomedcentral.com/ar... (full paper)
"Abstract
Background
The underlying pathophysiology of Parkinson's disease is complex, involving different molecular pathways, including brain iron deposition and mitochondrial dysfunction. At a molecular level, these disease mechanisms are likely interconnected. Therefore, they offer potential strategies for disease-modifying treatments. We aimed to investigate subcortical brain iron deposition as a potential predictor of the bioenergetic status in patients with idiopathic Parkinson’s disease.
Methods
Thirty patients with idiopathic Parkinson's disease underwent multimodal MR imaging (T1, susceptibility-weighted imaging, SWI) and 31phosphorus magnetic resonance spectroscopy imaging. SWI contrast-to-noise ratios served as a measure for brain iron deposition in the putamen, caudate, globus pallidus, and thalamus and were used in a multiple linear regression model to predict in-vivo energy metabolite ratios.
Results
Subcortical brain iron deposition, particularly in the putamen and globus pallidus, was highly predictive of the region-specific amount of high-energy-containing phosphorus metabolites in our subjects.
Conclusions
Our study suggests that brain iron deposition but not the variability of individual volumetric measurements are highly predictive of mitochondrial impairment in vivo. These findings offer the opportunity, e.g., by using chelating therapies, to improve mitochondrial bioenergetics in patients with idiopathic Parkinson's disease."
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"Key supplements that may chelate iron from the body include:
Turmeric
Quercetin
Resveratrol
Green Tea
Milk Thistle (potentially)*
*Research clearly shows that milk thistle lowers ferritin levels; however, scientists are not sure if this ferritin-lowering effect is due to chelation or a different mechanism of action."
Iron chelation by curcumin suppresses both curcumin-induced autophagy and cell death together with iron overload neoplastic transformation 2019 nature.com/articles/s41420-...
They do mention that while curcumin is anti-oxidant at low levels, it can be pro-oxidant at high levels. But also that it does chelate iron at low levels.
"Fortunately, various tools and treatments can help lower iron levels in the cells.
For example, this is how therapeutic phlebotomy benefits our health. Phlebotomy causes the body to release some of its stored iron by removing blood and generating a release of stored ferritin."
A quick Google shows therapeutic phlebotomy = leeching. Somebody owes those yesteryear doctors an apology for mocking leeching.
I have always had Hemochromatosis, then I started supplementing with Vitamin C (Limcee 500mg twice daily) for years because I read that smokers are deficient in Vitamin C.
I wonder if Hemochromatosis plus Vitamin C caused Brain Iron overload leading to my PD?
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Benfotiamine (Fat Soluble Form Of Vitamin B1) and AD
