Relationship between brain iron deposition and mitochondrial dysfunction in idiopathic Parkinson’s disease March 2022

[Bolt_Upright]

Relationship between brain iron deposition and mitochondrial dysfunction in idiopathic Parkinson’s disease March 2022 molmed.biomedcentral.com/ar... (full paper)

"Abstract

Background

The underlying pathophysiology of Parkinson's disease is complex, involving different molecular pathways, including brain iron deposition and mitochondrial dysfunction. At a molecular level, these disease mechanisms are likely interconnected. Therefore, they offer potential strategies for disease-modifying treatments. We aimed to investigate subcortical brain iron deposition as a potential predictor of the bioenergetic status in patients with idiopathic Parkinson’s disease.

Methods

Thirty patients with idiopathic Parkinson's disease underwent multimodal MR imaging (T1, susceptibility-weighted imaging, SWI) and 31phosphorus magnetic resonance spectroscopy imaging. SWI contrast-to-noise ratios served as a measure for brain iron deposition in the putamen, caudate, globus pallidus, and thalamus and were used in a multiple linear regression model to predict in-vivo energy metabolite ratios.

Results

Subcortical brain iron deposition, particularly in the putamen and globus pallidus, was highly predictive of the region-specific amount of high-energy-containing phosphorus metabolites in our subjects.

Conclusions

Our study suggests that brain iron deposition but not the variability of individual volumetric measurements are highly predictive of mitochondrial impairment in vivo. These findings offer the opportunity, e.g., by using chelating therapies, to improve mitochondrial bioenergetics in patients with idiopathic Parkinson's disease."

[JayPwP]

That is why I am wary of Vitamin C supplementation

[glenandgerry in reply to JayPwP]

Why?

[JayPwP in reply to glenandgerry]

Because it increases Iron absorption

[JayPwP]

Turmeric is reported to be an Iron Chelator

hemochromatosishelp.com/hem...

[Bolt_Upright in reply to JayPwP]

Interesting!

"Key supplements that may chelate iron from the body include:

Turmeric

Quercetin

Resveratrol

Green Tea

Milk Thistle (potentially)*

*Research clearly shows that milk thistle lowers ferritin levels; however, scientists are not sure if this ferritin-lowering effect is due to chelation or a different mechanism of action."

[Bolt_Upright in reply to JayPwP]

Iron chelation by curcumin suppresses both curcumin-induced autophagy and cell death together with iron overload neoplastic transformation 2019 nature.com/articles/s41420-...

They do mention that while curcumin is anti-oxidant at low levels, it can be pro-oxidant at high levels. But also that it does chelate iron at low levels.

[JayPwP in reply to Bolt_Upright]

Any thoughts on what is considered as high level in this case?

[Bolt_Upright in reply to JayPwP]

I liked this part of the article:

"Fortunately, various tools and treatments can help lower iron levels in the cells.

For example, this is how therapeutic phlebotomy benefits our health. Phlebotomy causes the body to release some of its stored iron by removing blood and generating a release of stored ferritin."

A quick Google shows therapeutic phlebotomy = leeching. Somebody owes those yesteryear doctors an apology for mocking leeching.

[JayPwP in reply to Bolt_Upright]

I believe blood letting is a safer doctor monitored alternative. I am worried about infections caused due to leeches.

[JayPwP]

I have always had Hemochromatosis, then I started supplementing with Vitamin C (Limcee 500mg twice daily) for years because I read that smokers are deficient in Vitamin C.

I wonder if Hemochromatosis plus Vitamin C caused Brain Iron overload leading to my PD?

Iron and dopamine: a toxic couple

academic.oup.com/brain/arti...