Okay, this is a LOT! Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases 2025

[Bolt_Upright]

For anybody trying to cure Parkinson's, this is likely a very important, and lengthy (about 55,000 words), article: Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases 2025 nature.com/articles/s41392-...

Some of you might know I pretty much stopped researching over a year ago and instead have focused on religiously sticking with my stack and seeing how things go. So far so good (I have not been diagnosed with PD. Details in my bio).

But just when you think you are out, an article like this pulls you back in!

I have to go make dinner, but I will return tomorrow and start adding some comments based on what I read.

Just a few notes from what I saw so far:

- This paper lists all the different metal ions and how their distribution in the brain varies in different neurological diseases (AD, PD, ALS, and HD). All of these have metal ion oddities but the oddities are different.

- Sometimes it is not just the amount of iron in the brain, but where it is located. Some areas have more than normal and some have less.

- People with iRBD have more iron in the substantia nigra than controls, and PwP have even more.

- MRI data has reported dynamics changes of nigral iron in PD, which are lower before dopaminergic medication and then increase throughout the disease, eventually plateauing at the late stages.209 In drug-naive PD patients, lower iron levels were identified in the SN, caudate nucleus, and GP compared to controls, but not in the red nucleus or putamen, however, higher nigral iron were found in drug-treated PD patients compared to controls or drug-naive PD patients.209 Notably, PD medications may result in differential association with nigral iron deposition. Higher nigral iron was found to be associated with levodopa usage, while lower nigral iron was correlated with selegiline usage.

- The paper also covers treatment options but I have not read them yet.

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I have to go.

[chartist]

This may have specific relevance for PD :

healthunlocked.com/cure-par...

Art

[Bolt_Upright in reply to chartist]

Thank Art. Lots of great info in that thread.

[gomelgo]

anything in there yet about other metals?

[Bolt_Upright in reply to gomelgo]

Yes. At least iron, manganese, copper, and zinc.

[gomelgo in reply to Bolt_Upright]

Thank you for doing this!

[JayPwP]

Thank you ⚡ 👍

[JayPwP]

Had come across this article in an earlier post here on HU some years ago regarding Brain Iron Accumulation

Hemochromatosis Supplements

hemochromatosishelp.com/hem...

[judykuenn]

My hubs was dx'd 4 yrs ago w/PD. Hemochromotosis 2 yrs ago. Will dig into this article..thanks for posting.

[Nuthatcher]

thank you for sharing this.

[redhawk1]

Bolt, from my understanding I think the foundation of the experimental drug ATH434 from Alterity Therapeutics is based upon redistributing or reducing the amount of iron in different areas of the brain. Thus far they seem to have had positive results in phase 2 of their MSA clinical trials. Next, if all goes according to their plans they believe this same drug may also be efficacious in treating Parkinson’s as well.

[MBAnderson]

donating blood lowers ferritin by 30-50ng/mL, which is a significant amount.

[posthinking01]

Vitamin C draws uptake of iron !