It sounds like a breakthrough. But how long before a Phase 1 clinical trial?
PNT article - Treating Stem Cells with Fasudil Eases Parkinson’s Symptoms in Mouse Model, Study Finds:
parkinsonsnewstoday.com/202...
Research paper - Intranasal Delivery of Bone Marrow Stromal Cells Preconditioned with Fasudil to Treat a Mouse Model of Parkinson’s Disease (2020):
From the PNT article:
" ... BMSCs migrated to the substantia nigra and olfactory bulbs within the animals’ brains."
So it seems that the BMSCs (bone marrow stromal cells) knew where to go, and how to get there!
... and here is how they did it:
"Another therapeutically important property of MSC [mesenchymal stem cells] is the ability to migrate to sites of injured tissue and inflammation due to signs generated by factors released at these sites. This migratory competence allows the administration of MSC through many routes in animal models with PD, for example intracerebral, intravenous, and intranasal."
Maybe a clinical trial is not so far away. There is currently a large trial (N=300) in Connecticut and Florida that involves both intranasal delivery and intravenous delivery of BMSCs. The estimated study completion date is June 2021.
clinicaltrials.gov/ct2/show...
The trial as described is, IMO, very poorly designed - no blinding, too many conditions under investigation etc. Added to this the dubious history of the organisation - ipscell.com/2019/11/critica... - I’d strongly urge people to stay well clear.
From a link within your linked article, it seems clear that MD Stem Cells are charging patients who take part in the NEST study. I think this is a big red flag.
"MD Stem Cells told [ALS patient Elsie] Johnson the company's RTT [Right to Try] treatment [for ALS] was $19,600, though she could get the same procedure through the clinic at $14,500 under its Neurological Stem Cell Treatment [NEST] Study."
spglobal.com/marketintellig...
Since there are no other clinical trials (that I could find) using intranasal delivery of stem cells, it could be a while before the Chinese mouse results make it into human trials.
Getting stuff across the BBB & exactly where you want it in the brain - through the nose, with ultrasound (in mice)
New Clinical Trial Starting: A Study of AAV2-GDNF in Adults With Moderate Parkinson's Disease (REGENERATE-PD) (REGENERATE-PD)
Acupuncture inhibits neuroinflammation and gut microbial dysbiosis in a mouse model of Parkinson’s disease 2020
Magnesium-L-Threonate Elevates The Magnesium Level In The Cerebrospinal Fluid And Attenuates Motor Deficits And Dopamine,,,
CDNF, Potential DMT for Parkinson’s, May Work as Nasal Spray
