I’m just going back through my husband’s DNA report from opus and noticed he has SNPs that mean he has high dopamine beta hydroxylase activity. I looked this up and apparently it sulphyryl compounds can inhibit this enzyme. On the list is coenzyme a .
I’ve found you can buy it on amazon. Reviews say it helps with acne and energy amongst other things and he has acne. It helps in fatty acid metabolism and I have long felt he has trouble in this area as he seems to produce too much oil on his skin.
Coenzyme A (CoA, CoASH or HSCoA) is the key cofactor in first step of the TCA cycle, responsible for transferring the acetyl group from pyruvate oxidation to oxaloacetate yielding citrate.
Coenzyme A is also a critical cofactor in fatty acid metabolism. Coenzyme A carries fatty acids through the catabolic/oxidation process in the mitochondria and transfers acetyl groups during the elongation process of fatty acid synthesis in the cytosol.
Coenzyme A facilitates removal of lipid peroxides by increasing mobilization of fatty acids, and promote repair of plasma membranes by activating phospholipid synthesis.
How coenzyme A is made in the body:
Pantothenic acid b5
ATP - eating foods with nucleotides in them eg offal,
It seems to come as bits that react together in the body to form it, rather than complete in itself. I found some on vitacost. One of the components is b5 pantothenic acid which is not very high in the Hardy’s product he takes, plus there is NAC and acetyl l carnitine which are already in the Hardy’s. Is it possible when it was working so well over summer autumn that we just happened to be eating enough of the other components for it to be produced by his body I wonder. Now winter is here the diet changes. I might buy some of this but in the meantime he has b5 added to his daily vitamin sipper bottle! And I’m going to feed him some green apples!
I am also wondering if the daily blackcurrant juice he has been having was helping him, but perhaps when he went onto a new bottle it was a slightly different cultivar with less of something critical in it.
No, I just have a scientific background in chemistry so I am interested in all things scientific! I wouldn’t feed my husband any supplements I haven’t researched “the science” behind and I know there are many people on this site interested in scientific information.
Not sure what product I’m supposed to be advertising. It’s not a brand, it’s a molecule.
If you read the above articles it explains what it is used for. It is used in the metabolising of fatty acids in the body. I think this is an area my husband has difficulty as he has always had greasy skin, acne and stomach aches after greasy food. The Parkinson’s smell is a greasy smell to my nose.
He also has a gene SNP that means his dopamine processing enzymes break it down very fast. This molecule is supposed to inhibit that enzyme so it should stop the dopamine being broken down so fast.
It has also been trialled as a drug to treat acne so even if it works for that it is a bonus!
I just wondered if anyone on this site has tried it as I can’t find anything about it in google to do with Parkinson’s. Coq10 seems popular, but not this one but it sounds like it might help with my husband’s energy and acne.
Well my husband has been taking extra b5 and glutathione (reduced) on top of his regular lot of supplements for 3 days now and I am cautiously optimistic that he is feeling a little better as he is talking, joining in conversations and laughing more than he had been. He only does this when he is feeling ok.
B5 is one of the precursors to the coenzyme a.
I’m not sure whether it is the b5 or glutathione that is helping him feel a little better. The improvement is subtle so far but noticeable.
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