Modafinil generic for Provigil

[Kwinholt]

Has anyone taken Modafinil or Provigil for fatigue? And if so did it help or is there any side effects? Thanks for the info. Karen

[park_bear]

Interesting:

en.wikipedia.org/wiki/Modaf...

" it was found to significantly affect only the dopamine transporter (DAT), acting as a dopamine reuptake inhibitor (DRI) ..., modafinil increases locomotor activity and extracellular dopamine concentrations in animals...and also inhibits methamphetamine-induced dopamine release... Another human PET imaging study similarly found that modafinil occupied the DAT and also determined that it significantly elevated extracellular levels of dopamine in the brain, including in the nucleus accumbens.[53]"

[Kwinholt in reply to park_bear]

Park Bear, So what is your opinion ? My dr has proscribed it for me but I’m waiting until the school year ends to try it just in case there was a weird side effect or if it isn’t for me and I reacted differently to it. Hence my question, has anyone been given this for fatigue? K

[park_bear in reply to Kwinholt]

I do not have personal experience with it and would defer to those who have. That said, it looks like a reasonable idea - per the quoted passage it slows down dopamine reuptake so it could be helpful for Parkinson's. We certainly need a good medication for Parkinson's fatigue. If you try it, do let us know your experience.

[Kwinholt in reply to park_bear]

PB, Thank you for your in put. I plan to give it a try around the second week of June and I will let you know the outcome . I’m hopeful . K.

[park_bear in reply to Kwinholt]

I did a bit more looking around. I would not call this a complete survey:

ncbi.nlm.nih.gov/pubmed/198...

The Modafinil group had a statistically significant improvement on ESS [Epworth Sleepiness Scale] (p < 0.05).

On the other hand this next study failed to reach statistical significance. There did seem to be a non-statistically significant improvement. Bear in mind that failure to reach stat sig does not prove that treatment does not work - what it says is the study failed to prove that the treatment does work:

jnnp.bmj.com/content/76/12/...

Results: Of a total of 40 subjects (29 men, mean (SD) age 64.8 (11.3) years), randomised to modafinil or placebo, 37 completed the study. Modafinil failed to significantly improve ES[Epworth Sleepiness Scale] scores compared with placebo (2.7 v 1.5 points improvement, respectively, p = 0.28). ... Adverse events were minimal.

List of studies:

4. Hogl B, Saletu M, Brandauer E, et al. Modafinil for the treatment of daytime sleepiness in Parkinson’s disease: A double-blind, randomized, crossover, placebo-controlled polygraphic trial. Sleep. 2002;25:905–909. [PubMed] [Google Scholar]

5. Adler CH, Caviness JN, Hentz JG, Lind M, Tiede J. Randomized trial of modafinil for treating subjective daytime sleepiness in patients with Parkinson’s disease. Mov Disord. 2003;18:287–293. [PubMed] [Google Scholar]

6. Ondo WG, Fayle R, Atassi F, Jankovic J. Modafinil for daytime somnolence in Parkinson’s disease: Double blind, placebo controlled parallel trial. J Neurol Neurosurg Psychiatry. 2005; 76(12):1636–1639. [PMC free article] [PubMed] [Google Scholar]

7. Lou JS, Dimitrova DM, Park BS, Johnson SC, Eaton R, Arnold G, Nutt JG. Using modafinil to treat fatigue in Parkinson disease: A double-blind, placebo-controlled pilot study. Clin Neuropharmacol. 2009;32(6):305–310. [PubMed] [Google Scholar]

8. Nieves AV, Lang AE. Treatment of excessive daytime sleepiness in patients with Parkinson’s disease with modafinil. Clin Neuropharmacol. 2002;25:111–114. [PubMed] [Google Scholar]

9. Lökk J. Daytime sleepiness in elderly Parkinson’s disease patients and treatment with the psychostimulant modafinil: A preliminary study. Neuropsychiatr Dis Treat. 2010;6:93–97. [PMC free article] [PubMed] [Google Scholar]

10. Rabinstein A, Shulman LM, Weiner WJ. Modafinil for the treatment of excessive daytime sleepiness in Parkinson’s disease: A case report. Parkinsonism Relat Disord. 2001;7:287–288. [PubMed] [Google Scholar]

11. Happe S, Pirker W, Sauter C, Klosch G, Zeitlhofer J. Successful treatment of excessive daytime sleepiness in Parkinson’s disease with modafinil. J Neurol. 2001;248:632–634. [PubMed] [Google Scholar]

[Kwinholt in reply to park_bear]

Thank you for all that info. It makes me more excited about a positive improvement. I’ll keep you updated when I begin to try it. Karen

[Kwinholt in reply to park_bear]

PB, I started taking the Modafinil 1/2 pill in the morning . Supposed to take a whole pill in the morning but that’s me trying to have control taking 1/2 to start. I do believe it’s helping . I have been feeling strong not so worn down. A couple days I have tried taking the other half around 11:00, so taking a whole pill but broken into two times. This weekend I am doing a Spartan Race in Monterey with my son, so after this weekend I will try the whole pill in the morning and see how that does. I am on (according to the pharmacist) a very low dose. I’m excited about this so we will see. Karen

[Jmellano]

hi kwuibholt. Do u still take modafinil and if so, is it helping ur fatufgue?