Lithium Orotate

[Kia17]

Lithium helps prevent mood swings, is anti-anxiety and antidepressant, promotes neurogenesis, protects from neurodegenerative disease, and is anti-aging.

nootropicsexpert.com/lithiu...

[Despe]

Hello, Kia!

Ordered it from Amazon after reading about its benefits. Dr. Mischley also recommends it to her patients. We have an appointment with her later this month, and I will ask her about it for more details.

[Kia17 in reply to Despe]

Hello

Please let us know your husband’s doctor views about the Lithium Orotate.

[Despe in reply to Kia17]

Will do!

[soup in reply to Despe]

I understood that Lithium used for treating Bipolar Disorder can cause Parkinson’s symptoms. Not sure if it might work like that in this preparation.

[Despe in reply to soup]

As I explained on another post, there are two different types of Lithium: Lithium Carbonate, prescription med for Bipolar Disorder and Lithium OROTATE, for neuroprotection and cognition. Lithium Orotate is a supplement which you can order on line or any health food stores.

[soup in reply to Despe]

Ok. Good luck.

[Despe in reply to soup]

Thank you. Perhaps, you should give it some thought.

[soup in reply to Despe]

I followed your link to the notropics site but was disappointed to find that it was implied that not being a drug made Lithium safe. I don’t have enough understanding of the toxicology of Lithium but Lead is not a drug and neither is Arsenic.

[Despe in reply to soup]

Sorry you feel that way, but it's a supplement without the side effects of prescription Lithium. If you follow the link Kia provided, you will be able to understand the difference.

[dalev in reply to Despe]

I was on Lithium Carbonate for depression,it felt like firecrackers were going off in my head, never took it again

[Despe in reply to dalev]

This is another form of Lithium (carbonate) you took, which is prescription med for Bipolar disorder.

[faridaro in reply to Despe]

Last month I had my first appointment with Dr. Mischley and she suggested Lithium Orotate 20mg/daily based on the results of my hair analysis which had shown very low lithium - it might be because of low lithium content in water in our area, although I've been taking 5mg of Li on and off for the past few years.

Would like to compare notes about your experience regarding lithium.

[Despe in reply to faridaro]

You bet! Are you feeling better?

[faridaro in reply to Despe]

Feeling more calm and less frustrated with everyday trials.

[Despe in reply to faridaro]

You will be doing even better after being a while on Lithium Orotate.

[PDConscience in reply to Despe]

Mischley did her 2012 thesis on Lithium (and carries ‘Vital Lithium Orotate’ 20mg at her Seattle clinic): digital.lib.washington.edu/...

[Stevenmast]

Wow! Very interesting post! Thank you! Steven

[park_bear]

Hmm. Concerning;

ncbi.nlm.nih.gov/pubmed/34690

"The creatinine clearance and the urine flow were significantly reduced in the rats given lithium orotate compared to those in each of the three other groups (P < 0.001). Urine flow was significantly higher in rats given lithium carbonate than in the sham treated group (P < 0.05). The kidneys weighed significantly more in rats given lithium orotate than in those in the three other groups (P < 0.001). Inspection of the kidneys showed those from rats given lithium orotate to be larger and paler than the kidneys from the other rats. The renal lithium clearance was significantly lower (P < 0.001) and the lithium concentrations in serum, kidney and heart were significantly higher (P < 0.001, 0-005 and 0.01, respectively) 6 h after the injection in rats given lithium orotate than in rats given lithium carbonate."

medicinenet.com/creatinine_...

" The kidneys maintain the blood creatinine in a normal range. Creatinine has been found to be a fairly reliable indicator of kidney function. Elevated creatinine level signifies impaired kidney function or kidney disease. As the kidneys become impaired for any reason, the creatinine level in the blood will rise due to poor clearance of creatinine by the kidneys. Abnormally high levels of creatinine thus warn of possible malfunction or failure of the kidneys."

[TeUruraki in reply to park_bear]

SO WHAT IS THE SIMPLE FACT YOUR GETTN AT ???

[Kkwondering in reply to park_bear]

What about lithium aspartate? My holistic MD prescribes the Li aspartate because it is safer for the kidneys.

[park_bear in reply to Kkwondering]

Smart MD. You can check lithium aspartate toxicity by doing a search on those terms.

[ElliotGreen in reply to Kkwondering]

livestrong.com/article/3169...

"Lithium aspartate and lithium orotate are available over-the-counter and contain lower dosages of lithium than lithium carbonate, which must be prescribed by a doctor. Most proponents of low-dose lithium therapy such as Dr. Jonathan Wright recommend them equally. However, aspartate is thought to be an excitotoxin, a substance that binds to nerve cell receptors and may cause damaging over-stimulation. Marlina E. Borkwood, MSc states that excitotoxins can cause headaches, brain edema, eye inflammation, vascular system and central nervous system problems in sensitive individuals. Those who want to try low-dose lithium therapy and have experienced sensitivity to another excitotoxin, monosodium glutamate -- a food additive commonly known as MSG -- may wish to stick with lithium orotate."

[PDConscience in reply to park_bear]

Without translation of trial dosage to human equivalents such info is useless drivel.

[park_bear in reply to PDConscience]

I agree the dosage should be translated into human equivalent. I am not taking this substance and do not care to take the time and effort to do so. However, in this study the same amount of lithium as lithium carbonate did not cause this problem. Personally, if I were taking lithium orotate I would be getting my creatinine level checked, and in my opinion it would be smart for others to do so.

[ElliotGreen in reply to park_bear]

They were injecting those rats with a fairly high dose. 2 mmol lithium per kg body weight is 14mg/kg body weight, or about 1100 mg of elemental lithium for somebody who weighs 80 kg. I'm not taking 1100 mg, I'm taking 5 or 10 mg. Of course it might add up over time. But on the other hand, aspartate "is thought to be an excitotoxin" (see the citation in my other comment).

Seems like it's an exercise of "pick your poison" if you want to get a low dose of lithium.

[park_bear in reply to ElliotGreen]

To arrive at human equivalent dosage we must adjust for metabolic rate. That adjustment for going from rats to humans is reduction by a factor of eight. So the human equivalent dose would be about 140 milligrams of elemental lithium. That said, the low dosages that you have suggested are far less and hopefully will not cause this sort of problem.

[ElliotGreen in reply to park_bear]

Thanks, that info about the metabolic rate translation is what my friend calls Good Knowledge.

Sometimes it seems like one has to get the equivalent of a PhD in order to make the best decisions for oneself in a health context, even when it comes to something that seems simple, like a supplement. And even then, it often comes down to a judgement call.

I thought I was being clever when I knew how to translate millimoles to milligrams, but I had no idea about species-level differences in metabolic rate. Makes sense though. There's the idea of "dogs' years", even though that's an approximation.

So many unknowns.

Thanks for sharing your knowledge and insight, Park_Bear.

[park_bear in reply to ElliotGreen]

I was off by bit - what I get for working from memory - actual factor is divide by six. Full table below. From: ncbi.nlm.nih.gov/pmc/articl...

Dose conversion

[ElliotGreen in reply to park_bear]

Wow! That's super useful. Thank you!

[Kia17]

Metabolic Evaluation of Parkinson’s Disease

Dr. Laurie K Mischley

youtube.com/watch?v=T1XrXvM...(Not working as expected?)

[MarionP]

In my thinking doing anything to mess with kidneys is a recipe for future and very difficult diseases. Therefore figuring out how to make lithium carbonate or lithium aspartate work for you. Aspartate may stimulate a little bit of skin itching and rashes in a few people but not in all cases. Protect your kidneys and liver!

[Kia17]

Lithium: The Untold Story of the Magic Mineral That Charges Cell Phones and Preserves Memory

greatplainslaboratory.com/a...