The first article you linked to gives clues about how LO is likely to be beneficial in PD. LO is an inhibitor of GSK3b and based on that article inhibition if GSK3b is likely to result in increased production of BDNF, both of which would be desirable in PD. Here is an article that discusses the role of GSK3b in PD :
As you can see inhibition of GkS3b might be useful in preventing dopaminergic neurons from death, but this is an animal study and a whole lot of definite maybes.
On the other hand melatonin is known to inhibit GSK3b.
>>> ' The literature reviewed here indicates that PD is associated with impaired brain expression of melatonin and its receptors MT1 and MT2. Exogenous melatonin treatment presented an outstanding neuroprotective effect in animal models of PD induced by different toxins, such as 6-hydroxydopamine (6-OHDA), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), rotenone, paraquat, and maneb. Despite the neuroprotective effects and the improvement of motor impairments, melatonin also presents the potential to improve nonmotor symptoms commonly experienced by PD patients such as sleep and anxiety disorders, depression, and memory dysfunction. ' <<<
Melatonin and PD seem to go together like hand and glove.
I’m up to 25 mg a nightI’ve been enjoying some improvements. Impossible to know the definite cause given all I’m doing but the research points to melatonin being a contributor.
Just fyi, it typically takes 2 weeks for Lithium orotate to start making a noticeable difference . I would recommend starting with 5mg or 10mg once a day for 2 weeks. If no difference, increase to 15mg for 2 weeks. If still no difference go to 20mg. After 20mg, if still no difference you can either quit or continue to increase, it's up to you. From what I understand, this dosage is safe.
In my case, I didn't feel any difference until multiple people were telling me how smart they think I am. This felt absolutely bizarre to me because of my history of debilitating brain fog. These people were doctors, nurses and bosses, all people I worked with , and they offered their opinions unsolicited. Really took me off guard, but then I realized that it had to be the lithium. I had been on it about 2 weeks at that point .
I also had a really bad bout of depression, which was unusual for me but really bad . The lithium cleared that right up.
Bassofspades thank you for the info! I have been taking it for memory rather than my PD issues along with some other memory improving suppliments for about 2 or 3 weeks. Waiting for someone to tell me how smart I am! Lol
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