Acute Morphine Treatments Alleviate Tremor

[Farooqji]

Morphine can be endogenously synthesized and can increase DA firing rate through disinhibition. In addition, upregulation of neuronal endogenous morphine-like compound immunoreactivity was found in human PD. These facts suggest morphine may have potential therapeutic relevance in PD treatment as dopaminergic neuron loss is related to Parkinson’s disease etiology. However, the use of morphine as a potential therapeutic for PD has not been reported. In this study, an initial investigation into the acute effects of exogenous morphine on PD symptoms was carried out. A rhesus macaque chronic PD model was established through MPTP intoxication. The evolution of PD symptoms were observed to be consistent with other progressive PD models. Following which the animals were treated with either L-Dopa or morphine, four PD symptoms, tremor, bradykinesia, imbalance and defensive reaction, were found to be differentially affected by either morphine or L-Dopa. However, we would concentrate on the changes of tremor and bradykinesia as the two symptoms were the primary PD symptoms. Most notably, morphine treated PD monkeys displayed significant improvements in tremor. This beneficial effect of morphine has not been reported before and indicates a potential therapeutic effect of morphine in PD treatment.

journals.plos.org/plosone/a...

frontiersin.org/articles/10...

Note:Opium puppy contains 12% Morphine

[park_bear]

Talk about a nonstarter