Autonomic and cardiac in PD

[aspergerian]

Multi-organ autonomic dysfunction in Parkinson disease.

Samay Jain, M.D., M.S.

Parkinsonism Relat Disord. 2011 Feb; 17(2): 77–83.

ncbi.nlm.nih.gov/pmc/articl...

Both pathologic and clinical studies of autonomic pathways have expanded the concept of Parkinson disease (PD) from a movement disorder to a multi-level widespread neurodegenerative process with non-motor features spanning several organ systems. This review integrates neuropathologic findings and autonomic physiology in PD as it relates to end organ autonomic function....

There is mounting evidence that PD affects a chain of neurons in autonomic pathways. Consequently, autonomic physiology may serve as a window into non-motor PD progression and allow the development of mechanistically based treatment strategies for several non-motor features of PD.

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Axonal α-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease.

Brain, Volume 131, Issue 3, 1 March 2008, Pages 642–650.

academic.oup.com/brain/arti...

Degeneration of the cardiac sympathetic nerve occurs in both Parkinson's disease (PD) and dementia with Lewy bodies and begins early in the disease progression of PD....

[vadehavet]

Scaring facts. PD has many faces. This makes sense and explains the autonomic disorders in PD. Thank you