THIAMINE. must read, excellent article - Cure Parkinson's
THIAMINE. must read, excellent article
"😀... there are no collateral effects of thiamin administration, even when used at high doses long-term (10).
In fact, thiamin is nontoxic to the body even at excess amounts (15), and doses as high as 3 to 8 grams per day have been used to treat Alzheimer’s disease without adverse effects (8). Only mild tachycardia appeared in one patient in the IBD study, which abated upon reduction of the dose (8)."
Don't forget me, I don't know why I get high blood pressure from thiamine HCL and also from benfotiamine. I still have not gone back on it, but I can definitely say when I was taking it my movement was way better. I have been off and on it again at least four times. It took a while before I got the high blood pressure the first time.. But now it comes up almost right away. I'll keep on trying it on and off.
I have an idea but first need to know, what are your normal blood pressures, lying down vs. standing up? and with thiamine?
Hi Park bear,
My first neurologist took my blood pressure first sitting down and then 5 minutes later I believe it was, standing up. Of course it was his nurse that did it. Never said anything to me about it so I just assumed it was okay. My blood pressure varies a lot during the day. I run between 120 to about 150 over 75 to about 90. I am onToprpl XL I take 25 mg a day in the morning.Also a1/3of a pill of Enalapril / diuretic. Not all the time, more on as-needed basis. When I first got the prescription and took a whole pill my blood pressure went down to 80 / 60. So I can't take a whole pill. Well, let me know what you are thinking. But both benfotiamine and thiamine HCL raise it to 200 over a hundred plus or minus . I took benfotiamine last year and I think I finished one bottle on the second one my blood pressure went high and I have no idea what made it that high, it took me awhile to connect it . This time with thiamine HCL again it took me probably about a month to start running High . The only good thing is I had an idea right away what it was. Mary
Oh my. Turns out I wasn't thinking anything useful. I went looking for thiamine and high blood pressure and all I found was a study saying it lowered blood pressure:
ncbi.nlm.nih.gov/pubmed/259...
They were only taking 3 × 100 mg/day. The only thought I have at this point is if you do try again, to keep your dosage low.
The article from GreenMedInfo seems to say the fat soluble thiamine--benfotiamine is better for our purposes, so why is the HCL form recommended?
Here is an excerpt from the article ------
Forms of Thiamin
One potential limiting factor of thiamin use is its poor bioavailability and slower absorption as a supplement, which is why high doses of thiamin are prescribed for certain medical conditions (3). To circumvent this issue, researchers have developed fat-soluble derivatives of thiamin called allithiamines. Benfotiamine, one lipophilic derivative of thiamin which readily diffuses through biological membranes, has been shown to have clinical benefit in diabetic vascular complications (3).
Its mechanisms of action includes reduction of advanced-glycation end products (AGEs), highly oxidant compounds with pathogenic significance in aging and chronic disease states (20), and modulation of pathways that play roles in cell survival, death, and repair (3). Impressively, benfotiamine also reduces activation of the nuclear factor kappa beta (NFkB) signaling pathway, the gateway to inflammatory eicosanoid mediators, and mitigates signaling down the arachidonic acid pathway, inhibiting the same cyclooxygenase (COX) enzymes (3) exploited by non-steroidal anti-inflammatory drugs (NSAIDs) without the deleterious side effects.
In addition, benfotiamine has been found to have free radical-scavenging properties via its ability to modulate levels of enzymes involved in endogenous antioxidant defense, such as catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) (3). Not only that, but benfotiamine reduces activity of glycogen synthase kinase 3 (GSK-3), which is involved in deposition of β-amyloid plaques in the brain in Alzheimer’s disease (3). Proof-of-concept of its neuroprotective abilities have been demonstrated in recent studies showing that benfotiamine reduces plaque accumulation, improves symptomatology (3), and inhibits progression of cognitive impairment in Alzheimer’s disease (21). Therefore, due to its pleiotropic effects, thiamin in this form has the potential to improve a host of chronic, inflammatory, and neurodegenerative conditions.
Sounds like we have another question for Easilly (Art) to ask Dr. C. Why hcl and not benfotiamine?
Oops! Roy Prop quoted Dr. C. regarding this in a previous post:
We don't use benfothiamine because previous trials report it does not enter in the neural cells, that's why it is not used for the diseases which don't affect the Central Nervous System (Bettendorff L.). We administer thiamine cloridrate.
Brilliant, illuminating, thank you.
Just read the article...thanks for posting. Interesting comment that polyphenolic compounds can inactivate thiamine, so does that mean no coffee? I was just about to start the day with bulletproof coffee.
Thank you for sharing this information.
I just started benfotiamine after a week on pharmaceutical grade b1 powder for my restless legs.. I could feel the difference after 3 days so switched to the fat soluble form. The pain has gone and for the first time in 5 years I feel like this is a lifeline. I take 4 benfotiamine a day. I hope this helps someone else.. I saw Dr. Bergs video on YouTubeand it's changed my life. I got an initial response with dmso but it didn't last now I know why. I hope to see other benefits as well.. like the night cough grrr..
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Thiamine and Benfo Thiamine Advice 
