Started taking b1 in capsule form;wondered how much to take;for best results?
Dose of b1: Started taking b1 in capsule... - Cure Parkinson's
Dose of b1
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jimmydook
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If Benfothiamine, 600mg/ day. If Thiamine HCL, 4g/ day
Always take the whole b complex and then add what you need in extra factors.
I take B1 sublingual and take 2x 100mg per day
Check out nutritional yeast. It, bakers yeast, and brewers yeast are all the same organism saccharomyces cerevisiae but nutritional yeast has been grown on molasses to try to get the nutrient content in it as high as possible. There is two types- fortified with b vits, and unfortified. The unfortified ones I looked at had lower b vitamin content than regular bakers or brewers yeast so not sure what is up with that. The fortified ones have really high thiamine, and other b vit content as can be seen on each one on iherb . I emailed now foods to ask them at what stage the b vits are added to the yeast. If it is when the yeast is still alive then it could take the thiamine HCL or mononitrate they give it, and metabolize it into the thiamine phosphates- which are more bio available- so that would be really good. If they add it once the yeast is dead then it will just be the same as taking a thiamine HCL/mononitrate pill. I have ordered myself some from ebay, and will begin on it soon. Bakers yeast/brewers yeast is still a good source of all the bs but the nutritional yeast looks better.
But if taking thiamine HCL or mononitrate capsules could just start at one 100mg capsule a day for 1-2 weeks, and then increase the dosage if needed. And if wanting a b complex pill there is doctors best fully active b vitamins on herb which contains the active form of all the bs (except thiamine), and no folic acid.
Thanks
If thiamine is effective for Parkinson's then there may be another possibility. There is a class of "smart" drugs called "nootropics". They are inexpensive, available on the Internet and don't require a Drs script.
One of those drugs is called "Sulbutamine". It was developed by the Japanese as a superior form of thiamine, a vitamin that cured an epidemic of "rickets" I think was the disease.
Very little thiamine will cross the blood brain barrier. However, Sulbutamine will and very efficiently! The drug is essentially two molecules of thiamine joined together through a "methyl group" of molecules that apparently soups-up the process.
I take it now and then when I want my mind to be calm & clear while I think and write. I can't say for sure that it will help Parkinson's but there appears to be little downside that I can detect. It might be worth a try.
If you want more on this I can heartily recommend the nootropicsexpert.com I think is his site. He's the best source of info I've found so far.
btw: I get mine from an outfit in Arizona called "Nootrpics Depot". But there are many suppliers that are probably just as good. It's just that they're close (I'm in SoCal) and they are American while some others seem to be out of the country. Also, I have no financial connections with them or any other related business whatsoever. Good luck!
I've just reread the sulbutamine section on nootropicsexpert.com and the disease the Japanese used it for was "beriberi" not rickets.
One other thing that came to mind that I was trying for a short time is called "methylene blue". You might read about it on the above website.
If it is only half a what's asserted it could turn out to be an effective adjunct to pd as well as many other health issues. Read up on it and see for your self.
Why not just take it daily, or do you not have Parkinson's?
Also, for what it is worth, sulbutiamine is lipid soluble which is apparently why it gets into the brain better than thiamine, which is water-soluble.
Subultiamine readily penetetrates the brain and exerts specific effects in brain function.
In Europe it is sold as "Arcalion". I buy it as over-the-counter medicine for 4 Euro ($5) from my local pharmacy.
At least in animal studies Sulbutiamine appears to increase Dopamine D1 Receptors in chronic use. Acute dose didn't have the same results.
Evidence for a modulatory effect of sulbutiamine on glutamatergic and dopaminergic cortical transmissions in the rat brain.
ncbi.nlm.nih.gov/pubmed/109...
"...In the same treated animals, an increase of D1 dopaminergic (DA) binding sites was measured both in the prefrontal and the cingular cortex, while no modification of the D2 binding sites was detected."
Use of sulbutiamine in the treatment of Parkinson's disease, schizophrenia, alcoholism, and dysthymia (PATENT US 5863925 A )
Effects of Sulbutiamine on Cognitive Slowing, Objective and Subjective, and on the Feeling of Fatigue of Parkinson's Patients
"The study was carried out on a population of patients having idiopathic Parkinson's disease, treated by L-dopa and/or dopaminergic agonists, stable on entry into the study, without major fluctuations of the motor state and without signs of dementia.
These patients were divided into 2 parallel groups and were treated under double-blind conditions for 8 weeks, either with sulbutiamine, or with a placebo, the treatments being allocated according to a randomization code.
By means of the following tests, we evaluated the effects of the treatment on:
1 - the cognitive functions, attention, verbal, ideational and motor slowing:
In Parkinson's patients, treated with sulbutiamine, an improvement in the cognitive, executive and mnesic functions was observed, with diminution of the sensation of fatigue. "
This study does not appear published in scientific journals.
Sulbutiamine - Scientific Review on Usage, Dosage, Side Effects
examine.com/supplements/sul...
Possibly many other nootropics like Citicoline and Uridine may have positive effects in the brain function of Parkinson's patients
Thanks i do have pd by the way; Will give it a try
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