Extended release Carbidopa Levodopa in any form causes me problems. This includes Rytary, extended release Carbidopa Levodopa and entacapone. I get bradykinesia and Dystonia. Speech changes (i can not say any thing i want to say but i can read out loud anything i see if i write it i can say it or if i just look at a key board and spell the words there i can say them. ) I will cuss and holler as loud as i can. I took 1entacapone tablet and 2 hours later i was on the floor hardly able to move or talk and my breathing was eratic and i was having Dystonia very badly. It went on for about a hour.
I am now taking 4 25/100 Carbidopa Levodopa tablets every 4 hours 6 times a day with little or no down time and no side effects. The only problem i have is not enough sleep but i am able to sleep better now. Some nights i get 6 hours of sleep some only 2 or 3.
I am 63 11 years DX. I believe i have all symptoms of Parkinson's except Tremor. Has any one had a problem like this.
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Bailey_Texas
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I was on rotary and by the end of the week I went back to sineret I started breathing fast and falling. When your breathing is affected time for a change
Looks like you found your dosage. Have you tried melatonin for sleep? It works beautifully for me, 6 to 10 hrs sleep, no side effects, I don't take every day
I take Rytary. I just read about dystonia and it sounds like what I get, Especially late in the day. It will last from suppertime to bedtime. Definitely affects breathing. Wears me out. I never connected it to the. Rytary. Anyone else get it?
I moved from 2 CD /LD every 4 daytime hours then added 1/2 pill more each time so I was taking 67 CD/250 LD. I began having severe and unpredictable down time. My Neuro said for some people the ratio of CD to LD can hinder the effectiveness of the LD. So he ordered me some 25 CD /250 LD and my off times immediately became much better. I don't know if that reasoning would help you Bailey, but it could be something you could talk over with your doctor.
The 4 25/100 carbidopa-levodopa i take every 4 hours works great. It is just the extended versions of carbidopa-levodopa that give me problems. Entacapone is just a extender only it contains no carbidopa-levodopa and when i take it i have the side effects.
Yes. The extended-release C/L appeared to mitigate my tremor to a slight degree but induced dystonia so bad I couldn't walk. I quit taking it. It was painful and debilitating. Before the extended C/L I took plain old sinemet but got the same result. Phooey!
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Slow release cardopa/levodopa 
Levodopa carbidopa starts to work 2:30 hrs after taking it...
Carbidopa Levodopa absorption may be delayed by eating fiber with dose. Would delays cause bigger problems with Continuous Release?
How I went from 13 to 4 a day (Carbidopa 25/Levodopa 100)?
