In Rheumatoid Arthritis, (RA) lymphocytes attack joints & cartilage. Normally the immune system targets microorganisms like virus, bacteria, fungi, and germs, etc. The immune system repeatedly subjected to infections leads to overproduction of antibodies - lymphocytes attack microorganisms but also attack host’s tissues - cartilage in the patient. RA is due to high levels of antibodies - these are like red flags which attach to bacteria but also to cartilage and synovium ( outer layer of cartilage.) The high level antibodies are significant because the intensity of the RA symptoms are less in patients when the antibodies are much lower.
Research & discoveries - show RA starts with hemolytic Streptococcus bacteria produce M protein but parts of the M Protein has similar configuration as Vimentin(a protein) and the body attacks vimentin in cartilage. Even when the Strept infection is gone, the immune system still attacks joints & cartilage since the antibodies remain high.
In fact fractions of M protein separated by enzyme – these fractions are pepM1, pep M5 & pepM18 all tested positive and RA antibodies crossreact with articular cartilage & synovium
See url J. Immunol. 1991, May 1
ncbi.nlm.nih.gov/pubmed/201...
Please READ - T Reg Cell- BECAUSE IT CURES AUTOIMMUNE CONDITIONS
en.wikipedia.org/wiki/Regul...
How to harness the T Reg Cell
The way to use T Reg cell - the method is Immune Tolerance and Oral Tolerance.
Oral tolerance is the suppression of immune responses to antigens (Ag) that have been administered previously by the oral route. Multiple mechanisms of tolerance are induced by oral Ag. Low doses favor active suppression, whereas higher doses favor clonal anergy/deletion.
Oral Tolerance is successful in Animals
View link- Success in Animals trials below:
books.google.ca/books?id=Fs...
But Oral Tolerance is not successful in humans.
The way to Success is a new discovery which is B7.
The Research by Dr. Polly Matzinger explains the T cells requirements.
The T cell needs 2 factors or signals for full activation.
1.) a peptide of vimentin, – the dose primes or makes ready theT cell. But without the 2nd signal the T cell remains in anergy( no activity).
2.) the Second signal is co-stimulation – is B7 also known as CD80 (B7-1) & CD86(B7-2) – either one is enough to make the T cell go thru the changes that makes it a fully activated cell.
Second Signal or Co- stimulation is explained at
en.wikipedia.org/wiki/Co-st...
Dr. Matzinger’s discovery is called Danger Theory because methods available to Modern Medicine able to in-duce B7 were Vaccines & Toxoids & byproducts from dangerous micro-organism & not applicable due to tox-icity including inflammation, fevers, fatigue from an overactive immune system ..
But Dr. Matzinger was not aware there is a nontoxic and safe method to induce B7 and that is through Herbs.
One last problem – Herbs that induce B7 by lymphocytes also induce Inflammation by lymphokines - Interfer-on,
Interleukin 6 & Tumor Necrosis Factors. Inflammation leads to more Antibodies which increases antibodies -failure. The problem is fixed by a 2nd herb that minimizes inflammation.
At this point, a successful formula is possible combining Oral Tolerance and 2 herbs – the 1st for B7 induction and the 2nd to inhibit production of inflammatory lymphokines.
People with Rheumatoid Arthritis also report other areas of the body affected – not just joints – skin, kidneys, muscles, lungs, eyes, heart, in fact almost all parts of the body. The reason is the antibody is to vimentin but Vimentin is important & functions as connective tissue – connective tissue is found in all parts of our bodies, however, the lower antibody from treatment will heal the joint and other vi-mentin areas so healing is usually all body parts.
How the formula works.
Sjogren's disease, RA & SLE are due to high antibodies, the immune system has generated many Helper T cells .
Oral Tolerance leads to proliferation of new Suppressor T cells, the new cells work against
Helper T cells & delete each other, when Helper T cells are removed, high antibodies to vimentin go down to normal, each course leads to improvement until there is complete healing.
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