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Been wondering lately how much of a role does inflammatory arthritis play in my mild depression that seems to be doggin me everyday. I know I'm one of the fortunate ones that does not have severe pain and I'm able to manage it through medication and diet. I guess I'm wondering if the leflunomide could possibly be causing a depression or is it just a side effect of living with this mile disease that I have. Although I don't write often please know that I'm thinking of all of you that are out there on the front lines of this disease. May you have days when you are not defined by this illness and you see the beauty of the world around you. God bless. U s h a

5 Replies

I have never taken leflunomide but I did suffer with mild depressive symptoms whilst taking sulpasalazine and these reduced when I reduced my dose. Living with chronic disease may well be a factor too.


Thank you for taking the time to write. I appreciate your thoughts. All the best u s h a



May I suggest you listen to the Emotions Matter Podcast Episode 26 with Steve Ozanich.

Also watch The Divided Mind interview with Dr John Sarno.

Both on You Tube


I believe it has a lot to do with the pain. Even mild it throws you off a bit. Please be sure to discuss everything, I mean literally everything, with your doctor. If it is related to any medication it needs to be watched. If you’re the kind of person to be able to keep a record or journal of how your feeling each day it would be very helpful. You won’t or don’t have to sound like your whining, especially about depression, just keeping you and your doctor aware of how everything is going. 😊🦋


I have found CBD oil very helpful for mood. I take a tincture of 24 mg (NuLeaf full spectrum, essentially no THC) morning and night. It helps with sleep too. Even mild pain, if chronic, affects you more than you may realize. You may have built up a tolerance so that you ignore pain in the background - in other words, it may not really be all that mild even. Regardless, your adrenals are always on alert and getting fatigued, and your sympathetic nervous system is activated, when you have any level of pain.


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