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Splitting methotrexate dose?

Hi all,

Ive been on methotrexatefor about 6 months now. At fitst i didnt have any side effects other than fatigue but abouy a month ago i started noy being able to stomach it. The doc told me to split the dose 3 pills after lunch 3 pills after dinner. But that didn't work either.

I decided to try splitting it farther apart over 24 period. Do you think im messing with my health and this is dangerous or its fine as long as i just take the prescribed dose 1once a week ?

BTW when i split it by 24h i haf no side effects at all.

10 Replies
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Ask your doctor for injectable mtx instead. More efficient with less side effects. What dose are you on? May be that your current dose is too high?

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Hi, I have been taking it also for 2years now and the only way I'm doing is splitting it within the 24 hours.

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I take 15mg - 6 pills of 2.5mg - and I split over 24 hours. My Dr said it is perfectly fine as long as you take it within 24 hrrs. I take 3 at dinner Monday and then again at dinner Tuesday. Always with food & lots of water. No stomach problems. Have been on MTHX for about 8-9 months. If you can keep up exercise it really helps.Good luck!

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I also took it split through out a 12 hr period but only got up to 15 mg day. Doc said that was fine. Awhile back I read a study that it works fine doing it that way

Many people choose to inject the med too

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I would ask to try injections no nausea for me since changing

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Of course, talk with your RA doc. My experience with splitting methotrexate doses has been good. I am on Omiprazole for stomach troubles as a side effect. I take this in the morning. After breakfast I take 3 tabs and after lunch I take 4. My doc said I can take with a meal or for better absorption on an empty stomach. I have been on this schedule for many years without problems. Again, talk to your doc about over what period of time you can split the doses. Good luck.

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Don't worry I have been doing the same thing. My doctor told me it was okay.Sometimes I split it up in three days.

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I've been on methotrexate for 12 weeks 20 mg weekly and in the last 3 weeks I'm suffering with blisters in my mouth and so tired can't see specialist until 27/06 was going to ask for injection form

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It is good to hear some positive posts on mtxe. I am only in my 2nd week of the lowest dose, 2.5 mg 3 x one day a week. I have now taken the 2nd week several days ago & am happy to say no nausea or other complaints. I was worried about it so this was a relief. But I can’t help but wonder when my rheumy increases the dosage (in Feb) if I can handle it. I have always had a queasy stomach, even riding in the back seat of a car, etc. I have made sure I ate a meal before taking it & am also taking the folic acid every day. Yes, my rheumy said daily. I even called the pharmacist because I continually read where ppl were saying skip the day you take the mtxe. If I reach a point where it makes me sick I will ask about injecting instead.

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Additional Methotrexate (MTX) experiences at NRAS forum, brcdeer1 (brc🦌1): healthunlocked.com/search/m... 👍

Numerous discussions on pros/ cons, benefits/ side effects, injectables/ tablets, splitting doses, increasing dosage, folic acid, etc.. 🤔

Very best wishes, brc🦌1. 🙏 🍀 🌺 🌞

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🎄 🔖 🎁 🎅 ❄️ ☃️ 🌨

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