TP53 Mutation

[Rocoo7319]

Can anyone provide me with any information on TP53 Mutation as to what i have been reading it's Lynch Syndrome and this mutation acts as a resister to chemo am I correct ?

[GCCA-Survivor Administrator]

Hi Rocoo7319,

Thank you for posting in Colon Cancer Connected. I'm sorry you are having to deal with this situation. TP53 does have a hereditary aspect to it. I do not know if the mutation acts as a resister to chemo. I did not find any information on that.

I did find this site to be of some value for information. I don't see where Lynch is specifically stated, but it is hereditary and therefore may be.

The investigation I've found show the following:

People with TP53 mutations have Li-Fraumeni syndrome (LFS).

Options for screening and early detection for men and women may include: comprehensive physical exam, rapid whole body MRI, colonoscopies, or other options depending on your personal and family history.

ambrygen.com/material/oncol...

Looks like it needs to be narrowed down by an oncologist as to exactly what is going on with a specific patient. I did see some clinical trials out there, but they look to be targeted to specific cases.

We do wish you the best in finding answers. Maybe there are some on this site that have experience with TP53. But again, it looks to be many variations and should be addressed to a specific individual.

~Tom, GCCA Survivor - Colon Cancer Connected Site Administrator.

Just a reminder - this group is here to offer support, share experiences, and offer our thoughts - but this is not medical advice, and you should always consult your medical professional(s). Additionally, for all emergencies, seek urgent medical care, never delay.

[Rocoo7319 in reply to GCCA-Survivor]

Thank you that helps I’ll definitely look it up and be speaking to my new oncologist.

[GCCA-Survivor Administrator in reply to Rocoo7319]

Please let us know what your oncologist has to say and how this will guide treatment for you.

We do wish you all the best in narrowing down the information as it pertains to your particular situation.