hello everyone
I was reading a post by someone who was discussing allopurinol and gout. I’ve been taking it with Imbruvica for a few years but after reading that thread im wondering if anyone can tell me if it’s necessary to take it forever like im gonna be taking Imbruvica forever ? Are there long terms issues with allopurinol ? Thanks
Hi GettinThrult,
In general, I believe that allopurinol is usually used for short period whenever our hematologists expect to have many CLL cells dying at one time. And I think there are some side effects that make it uncomfortable for long term use. Often on BTK or BCL-2 inhibitors, when we reach a stable level of CLL cells, there is no real need for it.
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You can read the past 256 discussions on allopurinol here: healthunlocked.com/cllsuppo...
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Also please look for the box on this page labeled: "Related Posts
*Who is taking Allopurinol with Imbruvica
*Allopurinol question
*Allopurinol question
*How many milligrams of Allopurinol were you prescribed?
*Rash with Imbruvica & Allopurinol
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Len
I've been taking Allopurinol since 2014 before CLL. I sill need Allopurinol to keep gout at bay, but have yearly uric acid blood test to make sure dose is correct.
My husband is starting ibrutinib next week and his dr wants him on the allopurinol for a few days before starting treatment and then 2-4 weeks total.
I’ve been taking 300 mg of allopurinol for about 30 years now, well before starting acalabrutinib, as far as I’m aware it’s well tolerated for long periods, and I’m evidence of that. But everyone is different.
Dave.
Its provide to prevent gout during the initial de-bulking of the CLL cells. As the CLL cells die they release Urich Acid into the blood stream. Once your lymphocytes are down to a reasonable level you can stop it (check with your consultant) I never took it, as it actually gave me gout...
Hello GettinThruIt
I have been on/off allopurinol 4-5 times. My doctors monitored me closely and longest period of use was couple of months. Doctors said long term use of allopurinol was not advisable, so as soon as my uric acid stabilized, I was taken off allopurinol.
GettinThruIt -
It shouldn't be necessary long term for CLL. But people without CLL do develop high uric acid and gout, often as they get older. Some gout is diet related, but there's also genetic causes:
healthline.com/health/gout/...
But I don't see genetic gout tests when I search for them. I think they just ask if siblings, parents, aunts, and uncles, grandparents, etc., have gout.
As far as safety and long term, it's best to review the package insert instructions:
accessdata.fda.gov/drugsatf...
=seymour=
Like many others, I was on Allopurinol for a few months after starting therapy with Brukinsa. After a few months, my oncologist had me stop taking it.
It's typically used short term to prevent kidney damage by the uric acid released when large numbers of CLL cells die rapidly in treatment.
Do have any other reason to take it? Gout?
History of uric acid kidney stones?
Good luck and God bless
Skipro
HIGH URIC ACID
ITCHY EYES SORES ON MY FACE.
Allopurinol with V &O treatment for CLL
Conflict- on imbruvica per oncologist, orthopedic disagrees 
