Cll leukemia

[Grock2]

Can you take omega xl with cll leukemia

[Spark_Plug]

Data on omega-3 for cancer prevention are inconclusive. It may reduce colon cancer risk (11); improve immune response in patients undergoing colorectal cancer resection (12); and reduce the incidence and severity of oxaliplatin-related neurotoxicity (74) but did not affect cancer outcomes (15) (43). Also, perioperative use of intravenous omega-3 resulted in infectious complications in patients undergoing elective colon resection for non-metastasized cancer (68). Conflicting data suggest beneficial association between higher omega-3 intake and improved survival among stage III colon cancer patients with wild-type KRAS and deficient MMR (69); supplementation also reduced occurrence of renal cell carcinoma in women (16). Furthermore, fish oil may lower the risk of breast cancer (36); improve overall survival (70) and xerostomia, but not toxicity (71) associated with neoadjuvant chemotherapy in patients with locally advanced breast cancer. Data from the Selenium and Vitamin E Cancer Prevention Trial (SELECT) showed high blood levels of omega-3 to be associated with increased risk of prostate cancer (17). In patients with sporadic colorectal neoplasia, EPA did not affect reductions in the proportion of patients with at least one colorectal adenoma when compared to aspirin or placebo (61). Also, in the prevention trial VITAL, supplementation did not lower incidence of invasive cancer or major cardiovascular events compared to placebo (62) although updated analyses show significant reduction in cancer mortality (75).

mskcc.org/cancer-care/integ...

What are your thoughts after reading this information?

[LeoPa]

You mean omega-3 fish oil capsules? You can but watch out for increased bleeding risk. A better way to ingest omega-3s is eating fish twice a week

[mrsjsmith in reply to LeoPa]

Omega-3 fish oil cannot be taken with Ibrutinib.

[LeoPa in reply to mrsjsmith]

I wouldn't know about that. The question was about CLL as such.

[mrsjsmith in reply to LeoPa]

That is my point exactly, that you are just offering blanket advice without any caveats.

[LeoPa in reply to mrsjsmith]

My point was that I was answering a specific question. Which did not mention Ibrutinib. If someone wanted to know whether he/she can combine omega-3 fish oil capsules with Ibrutinib, the person would formulate the question accordingly, don't you think?

[Kvb-texas in reply to LeoPa]

Would there be similar negative consequences if you consume high quality, extra virgin olive oil and flax seed in your diet every day?

[LeoPa in reply to Kvb-texas]

Hi, you mean whether those two increase bleeding risk? I'm not aware of that. In any case I would not heat extra virgin olive oil to more than 160 degrees Celsius. It is best used cold on salads. Carbon chains of poly unsaturated fats rearrange at high heat and become unrecognizable to the body. They become trans fats. Which are a disaster for human metabolism. Not to mention the smoking point of poly unsaturated fats is quite low. And burnt oil is carcinogenic too. I would definitely not consume flaxseed though. For multiple reasons. It is somewhat laxative. It is also quite difficult to make sure that it's fresh and the oil in it isn't rancid. It contains blockers of five alpha reductase. I read somewhere that in a very few cases it was suspected to have caused aggressive prostate cancer in males. But most importantly the bioavailability of the omega-3s it contains come nowhere close to the humble sardine. So for me there is no reason to waste money on it. I'd rather eat a tin of sardines which I can count as a meal and which has a lot more nutrition in it. Of course don't believe a word of what I just said without checking whether all of this is true 🙂 and the simplest way to do just that is to ask your preferred AI assistant. It should give you credible answers to any questions you might have and also come up with links to the relevant information sources. Best of luck and stay open-minded and willing to expand your knowledge!

google.com/url?q=https://ww...

[Big_Dee]

Hello Grock2

I would suggest making a distinction between CLL a blood cancer and other solid tumor cancers before taking an advertised supplement. CLLcanada was informed that omega fish oil cause clumping of platelets.

[bennevisplace in reply to Big_Dee]

I think that's wrong, and in fact omega 3 fish oil reduces platelet adhesion. CLL patients with a low platelet count, who already have an elevated risk of uncontrolled bleeding because of impaired clotting, are therefore advised against supplementing with high dose Omega 3 fish oil.

[AussieNeil Partner Administrator in reply to bennevisplace]

Yes, Big_Dee , as Bennevisplace recalled, CLL Canada came to the realisation that it was omega 3 fish oil that was causing the bruising under his eyes when he was having treatment, due to the reduced clotting effectiveness.

[Big_Dee in reply to AussieNeil]

Hello AussieNeil

So, the feeling is that fish oils are only detrimental when taken during treatment but not detrimental when not undergoing treatment?

[AussieNeil Partner Administrator in reply to Big_Dee]

I would say that it's not possible to make such a simplistic statement.

- There's been recent research showing that fish oil/omega 3 is of less help than was though would be the case with respect to cardiovascular diseases, so anyone taking a supplement really needs to re-evaluate the value of doing so with their cardiovascular specialist

- The bleeding risk determination is complicated where someone has CLL. It's not clear who is at risk. It seems to affect some and not others. For starters, for those of us with CLL who are not in treatment, some of us have perfectly normal platelet counts and some of us have low counts, commonly due to CLL bone marrow infiltration or incomplete recovery after treatment. Then some of us are on blood thinners, or we may be taking other supplements or drugs that also affect the platelet count or clotting.

- Then we have those with CLL on treatment, with all treatments often reducing the platelet count. Those on BTKi treatments are at most risk, because of the off target effect of BTKis on platelet function, due to the Tyrosine Kinase in platelets. Here, the impact varies both by the degree of off target effect by BTKi and the individual - how low their platelet count is and to what extent they are affected.

Certainly, anyone experiencing petechiae or bruising and taking omega 3 or even consuming a large amount of oily fish, should seriously review the risk/reward balance of doing so.

Neil