venetoclax and ibruvica update

[Eirinik]

hello everyone

hope everyone is doing well !!!

well my mom stopped venetoclax and ibruvica and has been off the drugs since the 25 April,

She is having a gastroenterologist check to see if her Malt lymphoma has left on the 21 May so I will keep you guys updated.

I was curious does anyone know how long after you stop the meds do they leave your body ?

And I’m again curious we stopped the therapy with no special test to see if she’s in remission or anything just the normal blood work we usually do. Has anyone had this happen to them ?

Thanks again

[AussieNeil Partner Administrator]

Hi Eirinik,

From your past post, I gather your Mom was on V+I for about 8 months? (It helps members better support you if you keep your bio up to date. Here's a short-cut link you can use for this purpose healthunlocked.com/profile/... ).

CLL treatments using venetoclax in combination with other drugs are administered for at least a year. I don't know about Extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue (MALT lymphoma) venetoclax treatments, but I expect that as with CLL, remission length will depend on how little of the MALT lymphoma is left when treatment is stopped.

With respect to "how long after you stop the meds do they leave your body?", the half lives of venetoclax/Venclexta and ibrutinib/Imbruvica are a matter of hours, so there should be no trace of either drug within a week. Unfortunately, as I have experienced, that doesn't mean that side effects also disappear after this time. My clinical trial nurse advised me that it can take a few months for those to abate and she was right. It takes time for our body to heal after the lymphoma has been removed.

Neil

[Eirinik in reply to AussieNeil]

Hello thank you for your response my mom tried gazyvya but got a severe allergic reaction so it was stopped immediately and then we started ibruvica and after three months we added venetoclax.

Thanks

[Skyshark]

This doesn't appear to be standard of care for Malt lymphoma, they have treated the CLL. V+I is usually a fixed duration treatment and testing is carried out a few weeks / month after completion. Expect another biopsy.

The drugs have a short half life of a few hours. A few days will eliminate the remaining drugs.

[Name-1]

I have MZL nodal/extranodal. My therapy was R+ Chl .PR.

R +Bendamustin (or Revlimid) is therapy for MZL. Maybe your mother have Helicobacter pylory?.Protocol for it is standard.

[Eirinik in reply to Name-1]

Thank you for your response she has malt lymphoma extronodal when the biopsy was done it’s was from b cells so the doctor told her it was from her cll and that we had to proceed with treatment