stopping Ibrutnib before surgery?

[Tapps]

stopping Ibrutinib before surgery?

[gardening-girl]

You should discuss this with your hematologist.

“Consider the benefit-risk of withholding IMBRUVICA® for at least 3 to 7 days pre- and post-surgery depending upon the type of surgery and the risk of bleeding.”

Prescribing Information

rxabbvie.com/pdf/imbruvica_...

[LeoPa]

Yes. I haven't read about anybody who did not.

[hhk50]

I did not stop Ibrutinib prior to Mohs surgery for a skin cancer or prior to a colonoscopy. In neither case did my specialist advise stopping. However now, with his recommendation, I am on a three-week Ibrutinib holiday to see the impact on my side effects and allow me to make a decision on switching to an I+V therapy. I am into week #3 of the holiday right now and will resume Ibrutinib in five days.

[hervec]

Bonjour

"Management of surgical procedures.

Ibrutinib should be held 3-7 days prior to and after any invasive procedures owing to the risk of periprocedural bleeding. Therefore, if a patient needs a surgical procedure, I attempt to get it done before initiating ibrutinib. This is particularly relevant for patients with a large disease burden or aggressive disease who may experience disease regrowth if ibrutinib is held early after initiating therapy. Once patients have been on ibrutinib for some time (>6-12 months) and achieved solid disease control, transient holds for procedures are not as problematic."

Source ashpublications.org/blood/a...

regards

Herve C