Epcoritamab

[Nicebaps]

Just wondering if there any UK CLLers that have started a clinical trial involving Epcoritamab and if so, how are they getting on with it?

[HopeME]

Hello Nicebaps:

I assume you have seen Dr. Koffman’s blog on his current treatment with Epcoritamab but in the off chance you haven’t I’ve provided the link below.

cllsociety.org/treatment-an...

Good luck and Happy New Year!

Mark

[Nicebaps in reply to HopeME]

I am in touch with Brian but was wondering if anyone in the UK was on it or about to start it?

[lankisterguy Volunteer]

Hi Nicebaps,

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As HopeME mentions, one of our best known friends & advocate bkoffman is in a trial for Epcoritamab and you can see a list of the 8 other postings that mention it here:

healthunlocked.com/cllsuppo...

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Len

[Agiledog in reply to lankisterguy]

Len,

Isn’t epcoritamab FDA approved for RR CLL?

Bud

[SeymourB in reply to Agiledog]

Agiledog -

I think it's just DLBCL and Follicular so far.

ir.genmab.com/news-releases...

But once approved for anything, it can be legally prescribed off label. The only catch is whether insurance will cover. It's had some good results in CLL in a small study:

cllsociety.org/2023/11/epco...

But much depends on comorbidities,which cannmake AEs more severe.

I think I would try Pirtobrutinib first. The whole sequencing of 2nd line and beyond changes as new results are released.

=seymour=

[Agiledog in reply to SeymourB]

Seymour,

Thanks. Just trying to stay a step ahead as I move along successfully in the BRUIN trial on V+R arm. Missed getting assigned to arm with pirto. But seems all for the best given the good I am getting from veneto and still having pirto waiting in the wings. Happy New Year.

Bud

[Skyshark]

Cornwall and London at present.

bepartofresearch.nihr.ac.uk...

[bkoffman CLL CURE Hero]

Trial has a long waiting list in the USA. Don't personally know any UK patients.

[johnliston in reply to bkoffman]

Is epcoritamab a time limited or continuous treatment?

john

[bkoffman CLL CURE Hero in reply to johnliston]

My trial is for for 5 years, so continuous but other similar BITEs are time limited and there are other trials looking time limited therapy combinations with epco or using it as a consolidatio0n therapy short term after other medications. It's approved as a continuous therapy for Lafarge B cell lymphoma in the USA. It's all very new in CLL.