Do Lym and Neu go down with ibrutinib ?

[Elnaazz]

Hello friends, wishing good health to all, my father has been taking ibrutinib for ten months and now his wbc is 27k but his Neu 3.4 , Lymp 22.6 and Neu% 12.5 , Lym% 83.7 are these numbers, please let me know if anyone has any experience.

[AussieNeil Partner Founder Admin]

Hi Elnazz,

With CLL, it's trends in the lymphocytes that are important. You posted 10 months ago that your father's WBC, which would have been mostly CLL cells, went from 370k to 600k. That initial increase often happens. For his lymphocyte count to have dropped to 22.6k since then, shows that ibrutinib has worked very well for him. His lymphocyte count should keep dropping the longer he stays on ibrutinib, until eventually his lymphocyte count may be normal again.

Neutrophils can drop while on ibrutinib. It's important for them to stay above 1.5k to reduce the risk of infection. A count of 3.4k is excellent.

Please ignore the percentage (%) figures. You only need them to work out the absolute counts we discussed above.

Neil

[BobbyFour in reply to AussieNeil]

Thanks Neil, you just answered a question I had - I assumed that significant immunocompromise always happens with treatment, even Ibrutinib monotherapy, but it seems that is not always the case.

[Elnaazz in reply to AussieNeil]

Thank you very much for your explanation. Yes, we were worried about the percentage of lym and Neu that did not go down.

[AussieNeil Partner Founder Admin in reply to Elnaazz]

This post gives example of how misleading tracking percentages can be. healthunlocked.com/cllsuppo...

It's the absolute counts and their trends which are important.

Neil

[Elnaazz in reply to AussieNeil]

By the way his wbc count is 27000 not Lymph

[AussieNeil Partner Founder Admin in reply to Elnaazz]

I've corrected the figure in my answer. Indeed 83.7% of 27k is 22.6k.

[Elnaazz in reply to AussieNeil]

Thank you so much for your reply it was helpful for me 🙏🏻🌸