Astrazenecas new antibody drug for immune compromised people

[craterlake]

msn.com/en-us/health/medica...

[cajunjeff]

I saw this earlier today. This seems to be the best bet for those of us who don't get an immune response to the vaccine.

I think the FDA will give emergency use authorization (EUA). What we need to know now is when will the EUA come out and when will the drugs be actually available to us.

Its all moving in the right direction now. The surge is letting up. With all the new surge infections and vaccines, we are closer to herd immunity. Covid is like a forest fire and we are like the trees (fuel). If we can reduce the fuel the fire might burn out better.

We have some new antivirals coming out. Covid remains extremely dangerous to us with cll, and others, but our chances for survival have improved greatly in the past year. This new drug will be our vaccine, or at least I think it is reasonable to hope it will be.

[craterlake in reply to cajunjeff]

Hi Jeff , good analogy with the forest fire concept . yes this looks to be a hopeful solution for some immune protection against covid for us .. the future is looking more promising for us cllers on all fronts .....

👍 james

[SlowCLL]

This is a very big deal, what follows is an excerpt from this morning's Washington Post.

"AstraZeneca said on Tuesday that it had asked the Food and Drug Administration to grant emergency authorization for a long-acting antibody treatment to prevent Covid-19 in people who are at high risk of the disease. If authorized, it would become the first such preventive treatment to be available in the United States, the company said.

The company said in a statement that the treatment had reduced the risk of symptomatic Covid-19 by 77 percent in a trial in which most participants either had other medical conditions that placed them at greater risk of severe illness or were not producing sufficient antibodies after vaccination.

It said the treatment could be used in conjunction with vaccines in people with weaker immune systems. Other antibody treatments in use in the United States, including one developed by the drug maker Regeneron, have mainly been used to treat people who are already infected with the coronavirus. The AstraZeneca treatment is designed to stay in the body for much longer than the available antibody treatments for Covid, the company has said.

“Vulnerable populations such as the immunocompromised often aren’t able to mount a protective response following vaccination and continue to be at risk of developing Covid-19,” Mene Pangalos, an executive vice president at AstraZeneca, said in a statement. “With this first global regulatory filing, we are one step closer to providing an additional option to help protect against Covid-19 alongside vaccines.”

Authorization for a long-acting antibody treatment to prevent Covid-19 in people who are at high risk of the disease. If authorized, it would become the first such preventive treatment to be available in the United States."

[bennevisplace]

Reliable ongoing protection is the dream of immunosuppressed folk, and this could be it. After all, in the phase 3 Provent trial, of the participants randomised to AZD7442 who did catch the virus, none became severely ill (three in the control group died).

Remember though that Provent really only got going last January. I just hope that Astra has enough data to convince the FDA and other regulators that the drug is effective against the Delta variant, which became the dominant strain in the UK around mid May, in the EU and the US around end June.

[LeoPa]

Is this an infusion or a drug?

[CLLerinOz Administrator Volunteer in reply to LeoPa]

It's administered by intramuscular injection. This earlier post has some additional information including a reply with a link to Astra Zeneca's most recent press release:

healthunlocked.com/cllsuppo...