False Richter Transformation

[Sepsur]

ashpublications.org/bloodad...

[Sushibruno]

I wish it would just disappear completely. I wish I can grab it by the neck and end it. 😁

[Jm954 Administrator]

Good paper and a start in understanding this issue but only 3 patients. We need more to see if there are any common features.

Jackie

[Sepsur in reply to Jm954]

I agree, I was disappointed by lack of numbers - I know of about 10 people myself, so far I am the only one who spontaneously transformed back before restarting medication

[Smakwater]

Good read Sep,

Here is what I see as the meat and potato course in the article.

These findings suggest that the Richter transformation described in this report likely represents an unstable B-cell clone and that sudden release of B-cell receptor signaling inhibition during interruption of ibrutinib therapy may be responsible for this clinical manifestation.

Interestingly, all patients had unmutated immunoglobulin heavy chain genes and TP53 disruption, which are frequently observed with Richter transformation.17

And then -

this observation warrants awareness among clinicians and further investigation of the underlying biological mechanisms.

JM

[AussieNeil Partner Administrator]

We discussed this paper more extensively 2 months ago:

healthunlocked.com/cllsuppo...

Neil